Results 81 to 90 of about 3,950 (160)

Epigenetic Regulation of EMT (Epithelial to Mesenchymal Transition) and Tumor Aggressiveness: A View on Paradoxical Roles of KDM6B and EZH2

Epigenomes, 2018
EMT (epithelial to mesenchymal transition) is a plastic phenomenon involved in metastasis formation. Its plasticity is conferred in a great part by its epigenetic regulation. It has been reported that the trimethylation of lysine 27 histone H3 (H3K27me3)
Camille Lachat, Michaël Boyer-Guittaut, Paul Peixoto, Eric Hervouet   +3 more
doaj   +1 more source

Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs

Haematologica, 2017
Histone methylation and demethylation regulate B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting cure rates. Since histone methylation status correlates with disease aggressiveness
Rohit Mathur, Lalit Sehgal, Ondrej Havranek, Stefan Köhrer, Tamer Khashab, Neeraj Jain, Jan A. Burger, Sattva S. Neelapu, R. Eric Davis, Felipe Samaniego   +9 more
doaj   +1 more source

Genetic variants in the KDM6B gene are associated with neurodevelopmental delays and dysmorphic features

American Journal of Medical Genetics Part A, 2019
AbstractLysine‐specific demethylase 6B (KDM6B) demethylates trimethylated lysine‐27 on histone H3. The methylation and demethylation of histone proteins affects gene expression during development. Pathogenic alterations in histone lysine methylation and demethylation genes have been associated with multiple neurodevelopmental disorders.
Elliot S. Stolerman, Elizabeth Francisco, Jennifer L. Stallworth, Julie R. Jones, Kristin G. Monaghan, Jennifer Keller‐Ramey, Richard Person, Ingrid M. Wentzensen, Kirsty McWalter, Boris Keren, Benedicte Heron, Caroline Nava, Delphine Heron, Katherine Kim, Barbara Burton, Fatima Al‐Musafri, Lauren O'Grady, Inderneel Sahai, Luis F. Escobar, Marije Meuwissen, Edwin Reyniers, Frank Kooy, Yves Lacassie, Meral Gunay‐Aygun, Krista Sondergaard Schatz, Ron Hochstenbach, Petra J.G. Zwijnenburg, Quinten Waisfisz, Marjon van Slegtenhorst, Grazia M.S. Mancini, Raymond J. Louie   +30 more
openaire   +6 more sources

Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice

Molecular Pain
Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease characterized by chronic visceral pain with a complex etiology and challenging treatment.
Zi-Long Yi, Jin-Nan Lu, Jin-Jin Zhu, Tian-Tian He, Yi-Ran Xu, Zi-Wei Huang, Yong-Chang Li, Guang-Yin Xu   +7 more
doaj   +1 more source

Kdm6b/Pdk1 Glycolytic Pathway-Driven Zeb2 Lactylation Promotes Cementogenesis

International Dental Journal
Aim or purpose: This study investigates the role of KDM6B-mediated glycolytic reprogramming in cementum regeneration, addressing the unclear mechanisms linking epigenetic-metabolic crosstalk to cementoblast mineralization.
Wang Xiaoxuan, Wang Huiyi, Yang Zhengkun, Cao Zhengguo   +3 more
doaj   +1 more source

MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B

Journal of Translational Medicine
Background Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development.
Si Wu, Xin Xu, Shiqi Gao, Sibei Huo, Mian Wan, Xin Zhou, Xuedong Zhou, Liwei Zheng, Yachuan Zhou   +8 more
doaj   +1 more source

Histone Demethylase KDM6B Promotes Postnatal Oligodendrocyte Development and Cortical Myelination

Abstract Myelination in the postnatal cortex requires epigenetic programs that activate oligodendrocyte gene networks. Here we show that the histone H3K27me3 demethylase KDM6B promotes this process in vivo . Conditional Kdm6b deletion (
Ruth Lambries, Zihan Shen, George I Mias, Jin He   +3 more
openaire   +3 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models

The Journal of Clinical Investigation
ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated with aggressive disease and poor prognosis. ASXL1 recruits Polycomb repressive complex 2 (PRC2) to specific gene loci to repress transcription through trimethylation ...
Guo Ge, Peng Zhang, Pinpin Sui, Shi Chen, Hui Yang, Ying Guo, Ivan P. Rubalcava, Asra Noor, Caroline R. Delma, Joel Agosto-Peña, Hui Geng, Edward A. Medina, Ying Liang, Stephen D. Nimer, Ruben Mesa, Omar Abdel-Wahab, Mingjiang Xu, Feng-Chun Yang   +17 more
doaj   +1 more source

KDM6B Gene [PDF]

, 2020
openaire   +1 more source