Results 31 to 40 of about 3,950 (160)
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Objectives Accumulating evidence show that histone demethylases play important roles in various types of cancers, including non-small cell lung cancer (NSCLC).
Ting Ge, Ying Zhou, Hongmin Lu
doaj +1 more source
KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice [PDF]
CellKenneth Hu +2 more
exaly +2 more sources
Molecular Medicine, 2022 Background The increasing incidence of non-alcoholic fatty liver disease (NAFLD) has been reported worldwide, which urges understanding of its pathogenesis and development of more effective therapeutical methods for this chronic disease.
Fei Zhao +4 more
doaj +1 more source
Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure
Biomolecules, 2023 (1) Background: There is an urgent need for effective treatments for cocaine use disorder (CUD), and new pharmacological approaches targeting epigenetic mechanisms appear to be promising options for the treatment of this disease.
Samara Vilca +4 more
doaj +1 more source
Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma
International Journal of Oncology, 2017 Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The current standard of care for patients suffering from MPM is a combination of cisplatin and pemetrexed (or alternatively cisplatin and raltitrexed). Most patients, however, die within 24 months of diagnosis.
Cregan, Sian +10 more
openaire +4 more sources
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade [PDF]
Nature Communications, 2021 Abstract Despite the genetic inactivation of SMARCA4 , a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient tumours. Here, we show that, unlike the cells with activated MYC
Octavio A. Romero +19 more
openaire +9 more sources
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis. [PDF]
PLoS ONE, 2016 Jumonji Domain-Containing Protein 3 (JMJD3)/lysine demethylase 6B (KDM6B) is an epigenetic modulator that removes repressive histone marks on genes. Expression of KDM6B mRNA is elevated in leukocytes from patients with ANCA-associated vasculitis (AAV ...
Jesper Brink Svendsen +5 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer and the cause of most cancer-related deaths. The molecular mechanisms that are involved in NSCLC development are currently not well understood.
Jun Ma +12 more
doaj +1 more source
KDM6B-Mediated HADHA Demethylation/Lactylation Regulates Cementogenesis. [PDF]
J Dent ResCementum, a bone-like tissue, is an essential component of periodontium, and periodontitis can lead to degenerative changes in the cementum, eventually resulting in tooth loss. The therapeutic strategy for advanced periodontitis is to achieve periodontal regeneration, of which cementum regeneration is a key criterion.
Yang Z +10 more
europepmc +4 more sources
Histone Demethylases KDM4B and KDM6B Promote Osteogenic Differentiation of Human MSCs [PDF]
Cell Stem Cell, 2012 Human bone marrow mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells with multilineage differentiation potentials including osteogenesis and adipogenesis. While significant progress has been made in understanding transcriptional controls of MSC fate, little is known about how MSC differentiation is epigenetically regulated.
Ye, Ling +7 more
openaire +3 more sources