Results 11 to 20 of about 3,950 (160)

KDM6B Variants May Contribute to the Pathophysiology of Human Cerebral Folate Deficiency

Biology, 2022
(1) Background: The genetic etiology of most patients with cerebral folate deficiency (CFD) remains poorly understood. KDM6B variants were reported to cause neurodevelopmental diseases; however, the association between KDM6B and CFD is unknown; (2 ...
Xiao Han, Xuanye Cao, Robert M. Cabrera, Paula Andrea Pimienta Ramirez, Cuilian Zhang, Vincent T. Ramaekers, Richard H. Finnell, Yunping Lei   +7 more
doaj   +4 more sources

KDM6B promotes gastric carcinogenesis and metastasis via upregulation of CXCR4 expression

Cell Death and Disease, 2022
KDM6B (Lysine-specific demethylase 6B) is a histone lysine demethyltransferase that plays a key role in many types of cancers. However, its potential role in gastric cancer (GC) remains unclear. Here, we focused on the clinical significance and potential
Fen Liu, Yue Wang, Zongcheng Yang, Xiujie Cui, Lixin Zheng, Yue Fu, Wei Shao, Lu Zhang, Qing Yang, Jihui Jia   +9 more
doaj   +3 more sources

Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice

Frontiers in Behavioral Neuroscience, 2022
Autism spectrum disorder (ASD) is a neurodevelopmental disease that has intellectual disability (ID) and attention-deficit/hyperactivity disorder (ADHD) as its common comorbidities. Recent genetic and clinical studies report that KDM6B, a gene encoding a
Yuen Gao, Mohammad B. Aljazi, Jin He
doaj   +3 more sources

Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination [PDF]

Frontiers in Cellular Neuroscience
IntroductionPostnatal cortical myelination requires epigenetic activation of oligodendrocyte gene programs, but the role of histone demethylases in vivo remains unclear.MethodsWe conditionally deleted Kdm6b in Emx1+ dorsal telencephalic progenitors and ...
Ruth Lambries, Zihan Shen, George I. Mias, George I. Mias, Jin He   +4 more
doaj   +2 more sources

hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine [PDF]

The Journal of Headache and Pain
Background Migraine is a disabling neurological disorder characterized by recurrent headache attacks and associated symptoms. The mechanisms underlying migraine remain unclear. This study aimed to identify differentially expressed circular RNAs (circRNAs)
Qihui Chen, Qingling Zhai, Jinghan Lin, Yanan Huang, Hongyan Li, Changman Zhang, Qijun Yu, Tingting Sun, Yonghui Pan   +8 more
doaj   +2 more sources

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data [PDF]

Frontiers in Immunology
BackgroundFerroptosis and cuproptosis are closely associated with hepatic ischemia-reperfusion injury (HIRI). However, the significance of metabolic cell death-related genes (MRGs) in HIRI still awaits exploration.
HongLi Yu, YingLi Cao, Jiebo Wang, Xianfeng Weng, Weituan Xu   +4 more
doaj   +2 more sources

Impact of KDM6B mosaic brain knockout on synaptic function and behavior

Scientific Reports
Autism spectrum disorders (ASD) are complex neurodevelopmental conditions characterized by impairments in social communication, repetitive behaviors, and restricted interests.
Bastian Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo C. Meza, Nicolas Merino-Veliz, Gino Nardocci, Lorena Varela-Nallar, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos   +9 more
doaj   +3 more sources

The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder [PDF]

The American Journal of Human Genetics, 2023
De novo variants are a leading cause of neurodevelopmental disorders (NDDs), but because every monogenic NDD is different and usually extremely rare, it remains a major challenge to understand the complete phenotype and genotype spectrum of any morbid gene. According to OMIM, heterozygous variants in KDM6B cause "neurodevelopmental disorder with coarse
Rots, Dmitrijs, Jakub, Taryn, Keung, Crystal, Jackson, Adam, Banka, Siddharth, Pfundt, Rolph, de Vries, Bert B.A., van Jaarsveld, Richard, Hopman, Saskia M.J., van Binsbergen, Ellen, Valenzuela, Irene, Hempel, Maja, Bierhals, Tatjana, Kortüm, Fanny, Lecoquierre, Francois, Goldenberg, Alice, Hertz, Jens Michael, Andersen, Charlotte Brasch, Kibæk, Maria, Prijoles, Eloise, Stevenson, Roger, Everman, David, Patterson, Wesley, Meng, Linyan, Gijavanekar, Charul, de Dios, Karl, Lakhani, Shenela, Levy, Tess, Wagner, Matias, Wieczorek, Dagmar, Benke, Paul, Lopez Garcia, María Soledad, Perrier, Renee, Sousa, Sergio, Almeida, Pedro, Simões, Maria José, Isidor, Bertrand, Deb, Wallid, Schmanski, Andrew, Abdul-Rahman, Omar, Philippe, Christophe, Bruel, Ange-Line, Faivre, Laurence, Vitobello, Antonio, Thauvin, Christel, Smits, Jeroen, Garavelli, Livia, Caraffi, Stefano, Peluso, Francesca, Davis-Keppen, Laura, Platt, Dylan, Royer, Erin, Leeuwen, Lisette, Sinnema, Margje, Stegmann, Alexander P.A., Stumpel, Constance T.R.M., Tiller, George, Bosch, Daniëlle G.M., Potgieter, Stephanus, Joss, Shelagh, Splitt, Miranda, Holden, Simon, Prapa, Matina, Foulds, Nicola, Douzgou, Sofia, Puura, Kaija, Waltes, Regina, Chiocchetti, Andreas, Freitag, Christine, Satterstrom, F. Kyle, De Rubeis, Silvia, Buxbaum, Joseph, Gelb, Bruce, Branko, Aleksic, Kushima, Itaru, Howe, Jennifer, Scherer, Stephen, Arado, Alessia, Baldo, Chiara, Patat, Olivier, Bénédicte, Demeer, Lopergolo, Diego, Santorelli, Filippo, Haack, Tobias, Dufke, Andreas, Bertrand, Miriam, Falb, Ruth, Rieß, Angelika, Krieg, Peter, Spranger, Stephanie, Bedeschi, Maria Francesca, Iascone, Maria, Josephi-Taylor, Sarah, Roscioli, Tony, Buckley, Michael, Liebelt, Jan, Dagli, Aditi, Aten, Emmelien, Hurst, Anna C.E., Hicks, Alesha, Suri, Mohnish, Aliu, Ermal, Naik, Sunil, Sidlow, Richard, Coursimault, Juliette, Nicolas, Gaël, Küpper, Hanna, Petit, Florence, Ibrahim, Veyan, Top, Deniz, Di Cara, Francesca, Louie, Raymond, Stolerman, Elliot, Brunner, Han, Vissers, Lisenka E.L.M., Kramer, Jamie, Kleefstra, Tjitske   +116 more
  +14 more sources

H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation

Molecular Therapy: Nucleic Acids, 2021
Lysine demethylase 6B (KDM6B) is a histone H3 lysine 27 (H3K27) demethylase that serves as a key mediator of gene transcription. Although KDM6B has been reported to modulate neuroinflammation after ischemic stroke, its role in ischemic brain injury is ...
Lisha Chang, Zhaowang An, Jiang Zhang, Fuling Zhou, Dali Wang, Jian Liu, Yunhe Zhang   +6 more
doaj   +1 more source

A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and Immunity

Frontiers in Genetics, 2022
Introduction: Epigenetic-targeted therapy has been increasingly applied in the treatment of cancers. Lysine (K)-specific demethylase 6B (KDM6B) is an epigenetic enzyme involved in the coordinated control between cellular intrinsic regulators and the ...
Jia-Tong Ding, Jia-Tong Ding, Xiao-Ting Yu, Jin-Hao He, De-Zhi Chen, Fei Guo, Fei Guo   +6 more
doaj   +1 more source