Results 1 to 10 of about 7,185 (124)

KDM6A promotes diabetic retinopathy via H3K27me3-dependent ferroptosis in Müller cells [PDF]

Cell Death and Disease
Diabetic retinopathy (DR), a leading cause of blindness, is driven by pathological angiogenesis and vascular leakage, but the underlying epigenetic mechanisms remain poorly defined. Here, we identify the histone demethylase KDM6A as a critical epigenetic
Yanjun Wen, Siyue Luo, Cheng Hu, Yikang Ji, Yulin Zhang, Xu Wang, Xin Huang, Yan Wei   +7 more
doaj   +2 more sources

KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression

Clinical and Translational Medicine, 2023
Background Hepatocellular carcinoma (HCC) is one of the major causes of death from cancer and has a very poor prognosis with few effective therapeutic options.
Yanfeng Liu
exaly   +2 more sources

KDM6A deficiency promotes tumor progression and resistance to cabozantinib treatment in clear cell renal cell carcinoma [PDF]

Scientific Reports
Lysine (K)-specific demethylase (KDM) 6A, a histone modifier with inhibitory roles in many types of cancers, is frequently mutated in clear cell renal cell carcinoma (ccRCC).
Yuki Kohada, Kohei Kobatake, Kenshiro Takemoto, Yohei Sekino, Takashi Babasaki, Kento Miura, Ryoken Yamanaka, Hikaru Nakahara, Ryo Tasaka, Takafumi Fukushima, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Osamu Kaminuma, Nobuyuki Hinata   +15 more
doaj   +2 more sources

Lysine demethylases 6 A and 6B as epigenetic regulators in therapeutic resistance of cancer [PDF]

Clinical Epigenetics
Histone 3 lysine 27 (H3K27) demethylation is a key post-translational modification of chromatin and plays a fundamental role in gene activation. Demethylation of H3K27 is mediated by Jumonji C domain-containing lysine demethylase 6 A (KDM6A) and its ...
Linzhu Yang, Haohan Li, Yunping Zhao, Zhuchao Qian, Guangcan Luo, Xiaobo Chen, Xudong Yang   +6 more
doaj   +2 more sources

KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC [PDF]

Cell Death and Disease
Abstact As a key tumor suppressor, KDM6A plays critical roles in maintaining epigenetic homeostasis and suppressing tumorigenesis. However, the regulatory mechanisms controlling KDM6A activity in head and neck squamous cell carcinoma (HNSCC) are not well
Jun Chen, Yikang Ji, Xin Chen, Mi Zhang, Mei Zhang, Xin Hu, Xing Xu, Yu Zhang, Zhen Zhang, Xinhua Pan, Ming Yan, Jianjun Zhang, Qin Xu, Xi Yang, Wantao Chen, Xu Wang   +15 more
doaj   +2 more sources

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes [PDF]

Nature Communications
The liver is a central organ controlling lipid and cholesterol metabolism and plays a key role in regulating lipoprotein profiles and cardiovascular disease risk.
Lin Chen, Zhanfang Kang, Jennifer Härdfeldt, Ziyi Li, Matteo Pedrelli, Qi Li, Ruining Lyu, Philipp Valina Allo, Taras Sych, Xiangru Zheng, Peibin Lin, Jianwen Zeng, Zhiqiang Huang, Oihane Garcia-Irigoyen, Sviatlana Sukhanava, Paolo Parini, Amélie Bonnefond, Erdinc Sezgin, Bo Angelin, Eckardt Treuter, Rongrong Fan   +20 more
doaj   +2 more sources

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility [PDF]

Advanced Science
Lysine demethylase 6A (KDM6A) is a critical epigenetic regulator implicated in development, cancer, and viral infection. Although KDM6A enhances coronavirus entry by modulating viral receptor expression, the mechanisms governing its protein stability ...
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
doaj   +2 more sources

Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer [PDF]

Nature Communications
Mutations in epigenetic regulators are common in bladder cancer, yet their impact on therapeutic responses remains unclear. Here, we identify that loss-of-function mutations in KDM6A, a histone demethylase altered in about 26% of advanced bladder cancers,
Pratishtha Singh, Ranit D’Rozario, Bidisha Chakraborty, Swadhin Meher, Deblina Raychaudhuri, Aminah J. Tannir, Yang Li, Anurag Majumdar, Jessalyn Hawkins, Yun Xiong, Philip Lorenzi, Padmanee Sharma, Kadir Akdemir, Patrick Pilie, Abhinav K. Jain, Byron Hing Lung Lee, Sangeeta Goswami   +16 more
doaj   +2 more sources

KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers [PDF]

Cell Death and Disease
Cancer-associated fibroblasts (CAFs) are activated fibroblasts that secrete numerous cytokines and chemokines to accelerate tumor progression. However, the mechanism underlying cytokine production by CAFs remains unclear.
Jieying Zhang, Suoyu Xiang, Dan Liu, Xiaomeng Pei, Meng Chen, Yiheng Zhao, Yongbin Wang, Qiong Wang, Lan Kang, Zuoren Yu, Jun Mi, Wujun Xiong   +11 more
doaj   +2 more sources

A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction

EMBO Molecular Medicine, 2019
Diabetic nephropathy is the leading cause of end‐stage renal disease. Although dysfunction of podocytes, also termed glomerular visceral epithelial cells, is critically associated with diabetic nephropathy, the mechanism underlying podocyte dysfunction ...
Chun-Wu Tung, Ching-Jen Wang, Pey-Jium Chang   +2 more
exaly   +2 more sources