Results 71 to 80 of about 7,235 (159)

A Data‐Driven Redefinition of Early Relapse in Pediatric T Cell Acute Lymphoblastic Leukemia: Evidence for Progression of Disease 15 Months

Med Research, Volume 2, Issue 2, Page 227-235, June 2026.
Data‐driven redefinition of early relapse in pediatric T‐ALL using hazard modeling, cumulative incidence, and time‐dependent HR across 1533 patients in three independent cohorts identifies 15 months as the optimal threshold. By integrating temporal risk metrics and external validation, this study provides evidence for POD ≤ 15 months as a data‐driven ...
Na Zhang, Wenli Tang, Yali Shen, Yance Feng, Hui Shi, Binjun Xiong, Hua You   +6 more
wiley   +1 more source

Loss of KDM6A/UTX Accelerate the Development of Multiple Myeloma

Blood, 2018
Abstract In multiple myeloma (MM), inactivating mutations and deletions affecting the histone demethylase KDM6A locus are found in up to 10% of newly diagnosed patients and associated with poor prognosis. KDM6A (also named UTX, Ubiquitously transcribed Tetratricopeptide repeat, X chromosome) belongs to a family of Jumonji-C (Jmj-C ...
Daphne Dupere-Richer, Jianping Li, Sayantan Maji, Crissandra Pipe, Sharon Norton, Teresa Ezponda, Richard Lynn Bennett, Jonathan D. Licht   +7 more
openaire   +1 more source

Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large‐Scale Japanese Genomic Panel Dataset

International Journal of Urology, Volume 33, Issue 6, June 2026.
ABSTRACT Objectives Urothelial carcinoma (UC) is a common malignancy; however, UC subtypes/divergent differentiation (S/DD) accounts for only 10%–20% of overall cases. S/DD's aggressive biological behavior significantly affects its prognosis and therapeutic decision‐making; thus, elucidating its genomic landscape within UC is important.
Go Kobayashi, Yohei Sekino, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Testutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata   +10 more
wiley   +1 more source

The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance

Epigenetics, 2017
Kabuki syndrome (KS) is caused by mutations in KMT2D, which is a histone methyltransferase involved in methylation of H3K4, a histone marker associated with DNA methylation.
Erfan Aref-Eshghi, Laila C. Schenkel, Hanxin Lin, Cindy Skinner, Peter Ainsworth, Guillaume Paré, David Rodenhiser, Charles Schwartz, Bekim Sadikovic   +8 more
doaj   +1 more source

Estrogen receptor β regulates sex‐dependent airway mechanics and inflammation in a murine model of allergen exposure

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Sex differences in asthma severity have been reported; however, the specific contribution of estrogen receptor β (ERβ) remains incompletely defined. We tested the hypothesis that ERβ modulates sex‐specific physiological responses to chronic allergen exposure using C57BL/6J wild‐type (WT) and ERβ‐deficient (Esr2−/−) male and female mice ...
Carolyn Damilola Ekpruke, Dustin Rousselle, Maksat Babayev, Omar Borges‐Sosa, Rachel Alford, Lyidia Dinwiddie, David Michael Merritt, Christopher Michael Hemmerich, Douglas B. Rusch, Sarah Bradley, Matthew Louis Retzner, Erik Parker, Patricia Silveyra   +12 more
wiley   +1 more source

<i>KDM6A</i> Variants Increased Relapse Risk in Adult Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Background/Objectives: The role of KDM6A gene mutations in acute myeloid leukemia (AML) remains poorly understood. This study aimed to evaluate the impact of KDM6A mutations on relapse risk, cumulative incidence of relapse (CIR), relapse-free survival (RFS), and overall survival (OS) in adult AML patients, with a particular focus on those with RUNX1 ...
Zhao Y, Niu L, Yang S, Yu L, Zhao T, Jiang H, Xu L, Wang Y, Zhang X, Huang X, Jiang Q, Tang F.   +11 more
europepmc   +3 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

KDM6A Loss Induces Aggressive Pancreatic Cancer in Mice [PDF]

Cancer Discovery, 2018
Abstract Loss of the X chromosome–encoded KDM6A aberrantly activates oncogenic superenhancers.
openaire   +1 more source

Intergenerational epigenetic inheritance of cancer susceptibility in mammals

eLife, 2019
Susceptibility to cancer is heritable, but much of this heritability remains unexplained. Some ‘missing’ heritability may be mediated by epigenetic changes in the parental germ line that do not involve transmission of genetic variants from parent to ...
Bluma J Lesch, Zuzana Tothova, Elizabeth A Morgan, Zhicong Liao, Roderick T Bronson, Benjamin L Ebert, David C Page   +6 more
doaj   +1 more source

Epigenetic mechanism of miR-26b-5p-enriched MSCs-EVs attenuates spinal cord injury

Regenerative Therapy
Mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) are promising therapies for the treatment of spinal cord injury (SCI). This study sought to explore the epigenetic mechanism of miR-26b-5p-enriched MSCs-EVs in SCI.
Jinghui Xu, Zhenxiao Ren, Tianzuo Niu, Siyuan Li   +3 more
doaj   +1 more source