The increasing global prevalence of obesity, exacerbated by factors such as high‐fat diets and reduced physical activity, poses a substantial risk for lifestyle‐related diseases, particularly in postmenopausal women. Premenopausal women initially have a lower incidence of cardiovascular disease than men, but this risk increases after menopause ...
Kazuya Kusama +7 more
wiley +1 more source
FGF9 alleviates diabetic cardiomyopathy by activating Nrf2 via SQSTM1/p62-Keap1 in mice. [PDF]
An N +5 more
europepmc +1 more source
Health Benefits and Therapeutic Potential of Quercetin
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley +1 more source
Survival impact of a KEAP1-NFE2L2 radiomics model in PDL1 ≥ 50% non-small cell lung cancer treated with pembrolizumab: the PEMBROMIC study. [PDF]
Le Meur C +7 more
europepmc +1 more source
Supplementary Table S4 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer [PDF]
Li Guan +27 more
openalex +1 more source
The growing demand for sustainable food sources has led to increasing interest in edible insects such as house cricket (Acheta domesticus) as functional ingredients. This study evaluated the anti‐inflammatory and antioxidant potential of cricket powder–enriched (10%) durum wheat pasta subjected to a simulated gastrointestinal digestion followed by the ...
Mussa Makran +9 more
wiley +1 more source
CVB3-induced P62 cleavage promotes ferroptosis through the NRF2/GPX4 axis and facilitates viral replication. [PDF]
He F +9 more
europepmc +1 more source
Excessive Vitamin E Supplementation: Implications for Ovarian Physiology and Reproductive Health
Infertility, a major global health problem affecting ~17.5% of couples, is influenced by various intrinsic (e.g., individual genetics) and extrinsic (e.g., related to environmental stimuli) factors. Oxidative stress and reactive oxygen species (ROS) are at the crossroads of these different stimulus–response pathways for both male and female gametes ...
Farzaneh Rabiee +8 more
wiley +1 more source
Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes. [PDF]
Georgakopoulos ND +13 more
europepmc +1 more source
Background Oxidative stress plays a crucial role in the pathogenesis of periodontitis and compromises the regenerative potential of human periodontal ligament stem cells (hPDLSCs). Astaxanthin (ASX), a potent natural antioxidant with both lipophilic and hydrophilic properties, has been shown to scavenge reactive oxygen species (ROS).
Jingwen Chi +8 more
wiley +1 more source

