Results 181 to 190 of about 21,045 (211)

Drynachromoside A from <i>Drynaria fortunei</i> attenuates oxidative stress and fibrosis of diabetic nephropathy via activating Nrf2 <i>in vitro</i> and <i>in vivo</i>. [PDF]

Redox Rep
Yao H, Li J, Wu R, Du D, Ai F, Li Y.
europepmc   +1 more source

CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition. [PDF]

Sci Rep
Hoshino M, Yasui Y, Mitsumata S, Ito Y, Kawauchi H, Komatsu R, Kimbara A, Horiba N.   +7 more
europepmc   +1 more source

Nodule-Specific NRF2-Targeted Upregulation in Patients With KEAP1 Mutations and Familial Nontoxic Multinodular Goiter.

J Clin Endocrinol Metab
Nishihara E, Fukata S, Hirokawa M, Higuchi M, Ito M, Nishikawa M, Miyauchi A, Matsuse M, Mitsutake N, Ito Y, Hishinuma A, Kogai T, Akamizu T.   +12 more
europepmc   +1 more source

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Leptinotarsa cap ‘n’ collar isoform C/Kelch-like ECH associated protein 1 signaling is critical for the regulation of ecdysteroidogenesis in the larvae

Insect Biochemistry and Molecular Biology, 2017
Drosophila cap 'n' collar isoform C (CncC) and Kelch-like ECH associated protein 1 (Keap1) regulate metamorphosis by transcriptional control of a subset of genes involved in ecdysteroidogenesis, 20-hydroxyecdysone (20E) signaling, and juvenile hormone (JH) degradation.
Guo-Qing Li
exaly   +3 more sources

Kelch-like ECH-associated Protein 1-dependent Nuclear Factor-E2–related Factor 2 Activation in Relation to Antioxidation Induced by Sevoflurane Preconditioning

Anesthesiology, 2017
Abstract Background The authors have reported that antioxidative effects play a crucial role in the volatile anesthetic-induced neuroprotection. Accumulated evidence shows that endogenous antioxidation could be up-regulated by nuclear factor-E2–related factor 2 through multiple pathways.
Min Cai, Li Tong, Wugang Hou
exaly   +3 more sources

Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors

Journal of Medicinal Chemistry, 2020
The Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2)-ARE (antioxidant response element) pathway is the major defending mechanism against oxidative stresses, and directly disrupting the Keap1-Nrf2 protein-protein interaction (PPI) has been an attractive strategy to target oxidative stress-related diseases ...
Qi-Dong You, Zheng-Yu Jiang
exaly   +3 more sources

Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates

Biochemical and Biophysical Research Communications, 2022
Fumarates (fumaric acid esters), primarily dimethyl fumarate (DMF) and monoethyl fumarate (MEF) and its salts, are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. It is widely believed that the pharmaceutical activities of fumarates are exerted through the Keap1-Nrf2 pathway. Although it has been revealed
Lingzhi, Qu, Ming, Guo, Huajun, Zhang, Xiaojuan, Chen, Hudie, Wei, Longying, Jiang, Jun, Li, Zhuchu, Chen, Shuyan, Dai, Yongheng, Chen   +9 more
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Abstract C126: Translational pharmacokinetic/pharmacodynamic (PK/PD) modeling of novel covalent Kelch-like ECH-associated protein 1 (KEAP1) activators

Molecular Cancer Therapeutics, 2023
Abstract Introduction: The KEAP1-nuclear factor erythroid 2-related factor 2 (NRF2) signaling axis is a key homeostatic mechanism for cells to maintain redox balance. In oxidative stress, reactive oxygen species (ROS) modify residues on KEAP1, impairing its binding and ubiquitination of NRF2.
Conrad Housand, Nil Roy, Tine Wyseure, Christie Eissler, Justine Metzger, Michaela Bairlein, Julie O'Brien, Melaminah Williams, Victor Contreras, Marine Garrido, Todd Kinsella, Jenna Goldberg, Matt Patricelli, Peter N. Morcos   +13 more
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Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization

Biochemical and Biophysical Research Communications, 2017
Keap1 constitutively binds to the transcription factor Nrf2 to promote its degradation, resulting in negative modulation of genes involved in cellular protection against oxidative stress. Keap1 is increasingly recognized as an attractive target for treating diseases involving oxidative stress, including cancer, atherosclerosis, diabetes, arthritis, and
Satoshi Sogabe, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, Jun-ichi Sakamoto   +5 more
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