Results 191 to 200 of about 21,045 (211)

Hydrogen Sulfide Alleviates Liver Injury Through the S‐Sulfhydrated‐Kelch‐Like ECH‐Associated Protein 1/Nuclear Erythroid 2–Related Factor 2/Low‐Density Lipoprotein Receptor–Related Protein 1 Pathway

Hepatology, 2021
Background and Aims Protein S‐sulfhydration mediated by H2S has been shown to play important roles in several diseases. However, its precise role in liver disease and the related mechanism remain unclear. Approach and Results We showed that in streptozotocin (STZ)–treated and high ...
Shuang, Zhao, Tianyu, Song, Yue, Gu, Yihua, Zhang, Siyi, Cao, Qing, Miao, Xiyue, Zhang, Hongshan, Chen, Yuanqing, Gao, Lei, Zhang, Yi, Han, Hong, Wang, Jun, Pu, Liping, Xie, Yong, Ji   +14 more
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Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors

Journal of Medicinal Chemistry, 2023
Oxidative stress has been implicated in a wide range of pathological conditions. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) exerts a central role in regulating the cellular defense system against oxidative and electrophilic insults.
Ziquan Zhao, Ruitian Dong, Qidong You, Zhengyu Jiang   +3 more
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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction

Journal of Medicinal Chemistry, 2021
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1, which regulates NRF2, is a key point for pharmacological intervention, and we recently described the ...
David Norton, William G. Bonnette, James F. Callahan, Maria G. Carr, Charlotte M. Griffiths-Jones, Tom D. Heightman, Jeffrey K. Kerns, Hong Nie, Sharna J. Rich, Caroline Richardson, William Rumsey, Yolanda Sanchez, Marcel L. Verdonk, Henriëtte M. G. Willems, William E. Wixted, Lawrence Wolfe, Alison J.-A. Woolford, Zining Wu, Thomas G. Davies   +18 more
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Homocysteine‐potentiated Kelch‐like ECH‐associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β‐catenin

European Journal of Neuroscience
Abstract Elevated serum homocysteine (Hcy) level is a risk factor for Alzheimer's disease (AD) and accelerates cell aging. However, the mechanism by which Hcy induces neuronal senescence remains largely unknown. In this study, we observed that Hcy significantly promoted senescence in neuroblastoma 2a (N2a) cells with elevated β ...
Yao, Zhang, Jia-Zhao, Xie, Yan-Li, Jiang, Shao-Juan, Yang, Hui, Wei, Ying, Yang, Jian-Zhi, Wang   +6 more
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„Kelch-like ECH-associated protein 1“ (KEAP1)

Trillium Krebsmedizin
In gesunden Zellen liegt das „Kelch-like ECH-associated protein 1“ (­KEAP1) im Zellplasma vor und ist dort gebunden an das Protein NRF2. Der KEAP1-NRF2-Signalweg schützt die Zelle gegen oxidativen und metabolischen Stress. Zudem verhilft er den Zellen dazu, körperfremde chemische Verbindungen (Xenobiotika) zu tolerieren.
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A polymorphism in a major antioxidant gene (Kelch-like ECH-associated protein 1) predicts incident cardiovascular events in chronic kidney disease patients

Journal of Hypertension, 2016
Oxidative stress is considered a major pathway conducive to cardiovascular disease in chronic kidney disease (CKD) patients. However, observational studies and clinical trials testing this relationship are controversial. The Nuclear factor-erythroid-2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) system is a major system ...
Testa, Alessandra, Leonardis, Daniela, Spoto, Belinda, Sanguedolce, Maria Cristina, Parlongo, Rosa M., Pisano, Anna, Tripepi, Giovanni, Mallamaci, Francesca, Zoccali, Carmine   +8 more
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Effects of deficiency of Kelch‐like ECH‐associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis

The FASEB Journal, 2017
ABSTRACT Kelch‐like ECH‐associated protein 1 (Keap1) binds to nuclear factor E2 p45‐related factor 2 (Nrf2), a transcription factor for antioxidant enzymes, to suppress Nrf2 activation. The role of oxidative stress in many diseases supports the possibility that processes that are associated with Nrf2 activation ...
Eiko, Sakai, Masanobu, Morita, Masahiro, Ohuchi, Mizuho A, Kido, Yutaka, Fukuma, Kazuhisa, Nishishita, Kuniaki, Okamoto, Ken, Itoh, Masayuki, Yamamoto, Takayuki, Tsukuba   +9 more
openaire   +2 more sources

Kelch-like ECH-associated Protein 1-nuclear Factor Erythroid 2-related Factor 2 Pathway Activation in Neuroprotection and Cognitive Enhancement

International Neuropsychiatric Disease Journal
Neurodegenerative diseases and cognitive decline pose significant global health challenges. The Kelch-like ECH-associated protein 1 (Keap1) – nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is a master regulator of cellular defense against oxidative stress and inflammation, factors implicated in these conditions.
Onoriode Andrew UDI, Charles German IKIMI   +1 more
openaire   +1 more source

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

Journal of Medicinal Chemistry, 2016
The transcription factor Nrf2 is the primary regulator of the cellular defense system, and enhancing Nrf2 activity has potential usages in various diseases, especially chronic age-related and inflammatory diseases. Recently, directly targeting Keap1-Nrf2 protein-protein interaction (PPI) has been an emerging strategy to selectively and effectively ...
Zheng-Yu, Jiang, Meng-Chen, Lu, Qi-Dong, You   +2 more
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[Kelch-like ech-associated protein 1/nuclear factor E2-related factor 2/antioxidant response element pathway alleviates ferroptosis in sepsis by regulating oxidative stress].

Zhonghua wei zhong bing ji jiu yi xue, 2021
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and has a high morbidity and mortality worldwide. The characteristic of sepsis is the inflammatory reaction. Cytokines produced by the severe inflammatory reaction can activate neutrophils and cause excessive production of reactive oxygen species (ROS ...
Jiarou, Li, Hongliang, Wang
openaire   +1 more source