Results 111 to 120 of about 10,759 (233)

Proteoglycans and Hyaluronan in Normal and Aberrant Lung Development

Proteoglycan Research, Volume 3, Issue 2, April 2025.
ABSTRACT Lung development is a tightly regulated process that progresses through five distinct stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Each stage is characterized by coordinated cellular interactions and structural changes driven by signals from epithelial, endothelial, and mesenchymal cells.
Andrea Reszegi, Gabor Petovari, Nikitha Damisetty, Stavros Garantziotis, Rashmin C. Savani   +4 more
wiley   +1 more source

Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains [PDF]

, 2012
The nanostructure and nanomechanical properties of aggrecan monomers extracted and purified from human articular cartilage from donors of different ages (newborn, 29 and 38 year old) were directly visualized and quantified via atomic force microscopy ...
Grodzinsky, Alan J., Han, Lin, Lee, Hsu-Yi, Ortiz, Christine, Roughley, Peter J.   +4 more
core   +1 more source

Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study

Arthritis Research & Therapy, 2017
Background We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction.
Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole, Naoki Ishiguro   +6 more
doaj   +1 more source

Identification of the keratan sulfate attachment sites on bovine fibromodulin

Journal of Biological Chemistry, 1990
The small keratan sulfate-substituted proteoglycan (fibromodulin) from articular cartilage was shown to contain keratan sulfate linked to the core protein through N-glycosidic linkages to residues Asn-109, Asn-147, Asn-182, and Asn-272. Biosynthetic experiments with articular chondrocytes in the presence of tunicamycin, an inhibitor of N-linked ...
Peter J. Neame, Anna Plaas, C. M. Nivens, L. Reiss   +3 more
openaire   +2 more sources

Integration of clinical data with a genome‐scale metabolic model of the human adipocyte

Molecular Systems Biology, 2013
We evaluated the presence/absence of proteins encoded by 14 077 genes in adipocytes obtained from different tissue samples using immunohistochemistry. By combining this with previously published adipocyte‐specific proteome data, we identified proteins ...
Adil Mardinoglu, Rasmus Agren, Caroline Kampf, Anna Asplund, Intawat Nookaew, Peter Jacobson, Andrew J Walley, Philippe Froguel, Lena M Carlsson, Mathias Uhlen, Jens Nielsen   +10 more
doaj   +1 more source

Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous System during Development [PDF]

, 2013
Neuronal axons and their growth cones recognize molecular guidance cues within the local environment, forming axonal pathways to produce precise neuronal networks during nervous system development.
Ichijo Hiroyuki, Kimata Koji, Sugiura Nobuo   +2 more
core   +3 more sources

Polymorphisms in Tunisian patients with N-acetylgalactosamine-6-sulfate sulfatase gene deficiency: Implication in Morquio A disease

Diagnostic Pathology, 2011
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes.
Chkioua Latifa, Khedhiri Souhir, Ferchichi Salima, Miled Abdelhedi, Laradi Sandrine   +4 more
doaj   +1 more source

Unique glycosylation of three keratan sulfate proteoglycan isoforms

Journal of Biological Chemistry, 1991
Recent work demonstrates isoforms of bovine corneal keratan sulfate proteoglycan containing structurally unique core proteins of 25 and 37 kDa (Funderburgh, J., and Conrad, G. (1990) J. Biol. Chem. 265, 8297-8303). In the current study, two forms (37A and 37B) of the 37-kDa protein were separated by ion-exchange chromatography after removal of keratan ...
Martha L. Funderburgh, James L. Funderburgh, Gary W. Conrad, Mary M. Mann   +3 more
openaire   +3 more sources

Long-term endurance and safety of elosulfase alfa enzyme replacement therapy in patients with Morquio A syndrome [PDF]

, 2016
Long-term efficacy and safety of elosulfase alfa enzyme replacement therapy were evaluated in Morquio A patients over 96weeks (reaching 120weeks in total from pre-treatment baseline) in an open-label, multi-center, phase III extension study.
AlSayed, MD, Berger, KI, Burton, BK, Giugliani, R, Guelbert, N, Harmatz, PR, Hendriksz, CJ, Hughes, DA, Jurecki, E, Matousek, R, Mitchell, JJ, Parini, R, Raiman, J, Shaywitz, AJ, Slasor, P, Solano Villarreal, ML, Stewart, F   +16 more
core   +1 more source

Glycosaminoglycans and Proteoglycans

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +1 more source