Results 111 to 120 of about 410,791 (266)

Aggrecan structure in amphibian cartilage

Brazilian Journal of Medical and Biological Research, 2000
The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14.
Covizi D.Z., Carvalho H.F.
doaj  

Unique glycosylation of three keratan sulfate proteoglycan isoforms

Journal of Biological Chemistry, 1991
Recent work demonstrates isoforms of bovine corneal keratan sulfate proteoglycan containing structurally unique core proteins of 25 and 37 kDa (Funderburgh, J., and Conrad, G. (1990) J. Biol. Chem. 265, 8297-8303). In the current study, two forms (37A and 37B) of the 37-kDa protein were separated by ion-exchange chromatography after removal of keratan ...
J L, Funderburgh, M L, Funderburgh, M M, Mann, G W, Conrad   +3 more
openaire   +2 more sources

Tissue engineering for tendon and ligament repair: Insights and advances

VIEW, Volume 6, Issue 6, December 2025.
Tendon and ligament injuries are widespread diseases, leading to severe pain and a consequent reduced mobility. This phenomenon is mainly due to the limited ability to self‐healing of these tissues. Unfortunately, the currently available surgical and rehabilitative treatments suffer frequent complications and incomplete success.
Francesca Romano, Francesco Lopresti, Roberto Di Gesù, Vincenzo La Carrubba   +3 more
wiley   +1 more source

Diversity and development of the hemibacula of croaking geckos (Sphaerodactylidae: Aristelliger)

Journal of Anatomy, Volume 247, Issue 6, Page 1145-1156, December 2025.
Geckos in the genus Aristelliger exhibit enigmatic mineralized elements in their hemipenes, called hemibacula. We examined hemibacula of every species of Aristelliger using μCT, clearing and staining, and histology. We found hemibacula exhibit lineage‐specific morphology, isometric growth after sexual maturity, and are composed of mineralized ...
Aaron H. Griffing, Daniel J. Paluh, Jonathan C. DeBoer, Juan D. Daza, Tony Gamble, Anthony P. Russell, Aaron M. Bauer   +6 more
wiley   +1 more source

M2 Macrophage‐Derived Migrasomes Mediate Ischaemia‐Induced Retinal Neovascularization by Targeting TREM2

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
M2 macrophages produced and released TREM2‐enriched migrasomes, which were internalized by HRECs through macropinocytosis and phagocytosis. Subsequently, migrasomes up‐regulated pathological retinal angiogenesis and biological functions of HRECs by targeting downstream molecules (BTC, PLA1A, etc).
Bingyan Li, Junyu Chen, Junye Zhu, Haixiang Zhou, Qiuxiang Zhang, Hui Deng, Haipeng Wen, Fan Xu, Fen Tang, Shigeo Yoshida, Yedi Zhou   +10 more
wiley   +1 more source

Prenatal diagnosis of morquio disease type A using a simple fluorometric enzyme assay [PDF]

, 1990
A new fluorogenic substrate, 4 methylumbelliferyl B-D-6-sulphogalactoside, was used for the assay of galactose-6-sulphate sulphatase activity in chorionic villi, cultured villus cells, and amniocytes. The fluorometric assay is much more convenient than
Diggelen, O.P. (Otto) van, Huijmans, J.G.M. (Jan), Kleijer, W.J. (Wim), Mazurczak, T., Thoomes, R. (R.), Young, E., Zhao, H. (Hui)   +6 more
core   +2 more sources

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, Volume 26, Issue 20, October 31, 2025.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source

Enzyme Replacement Therapy With Elosulfase Alfa Decreases Storage of Glycosaminoglycan in White Blood Cells of Patients With Morquio A Syndrome

Journal of Inborn Errors of Metabolism and Screening, 2015
Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by a deficient N-acetylgalactosamine-6-sulfate sulfatase activity, leading to cellular storage of undegraded keratan sulfate.
Guilherme Baldo PhD, Fabiano Poswar MD, Andressa Federhen MSc, Camila Bittar MD, Rejane Gus PhD, Fernanda Bender MSc, Roberto Giugliani MD, PhD   +6 more
doaj   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, Volume 15, Issue 10, Page 1552-1569, October 2025.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Macular corneal dystrophy with isolated peripheral Descemet membrane deposits

American Journal of Ophthalmology Case Reports, 2019
Purpose: Macular Corneal Dystrophy (MCD, MIM #217800) is a category 1 corneal stromal dystrophy as per the current IC3D classification. While characterized by macular stromal deposits, we report a case of MCD type II with isolated bilateral peripheral ...
Wenlin Zhang, Austin Connor Kassels, Alice Barrington, Shaukat Khan, Shunji Tomatsu, Turad Alkadi, Anthony Aldave   +6 more
doaj   +1 more source