Results 141 to 150 of about 5,745 (171)
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Brain Keratan Sulfate and Glial Scar Formation
Annals of the New York Academy of Sciences, 2006Abstract: In response to injury to the central nervous system (CNS), reactive astrocytes appear and accumulate in the wounded area, leading to glial scar formation. Glial scar is the physical barrier to axonal regeneration of injured neurons. Chondroitin sulfate proteoglycans are inhibitory to axon outgrowth and are upregulated in reactive astrocytes
Haoqian, Zhang +2 more
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Serum keratan sulfate levels in osteoarthritis patients
Arthritis & Rheumatism, 1988AbstractSerum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more
M B, Sweet +7 more
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Impaired degradation of keratan sulfate in GM1-gangliosidosis
Clinica Chimica Acta, 1982Abstract We have prepared a new radiolabeled substrate (galactose-N-acetylglucosamine 6-sulfate-[1-3H]galactitol), from shark cartilage keratan sulfate, for an assay of acid β-galactosidase activity. Using this substrate, we found that there was a striking deficiency of β-galactosidase activity in the cultured skin fibroblasts of patients with GM1 ...
T, Yutaka +3 more
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Keratan Sulfate as a Potential Biomarker of Loading of the Intervertebral Disc
Spine, 1998A review of the literature.To investigate the potential of serum levels of keratan sulfate as a biomarker of the effects of loading of the spine.Exposure to mechanical loading of the spine causes changes in metabolism of intervertebral discs, eventually leading to accelerated disc degeneration.
Kuiper, J. I. +3 more
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Fluorous-Tag Assisted Syntheses of Sulfated Keratan Sulfate Oligosaccharide Fragments
Organic Letters, 2016The first block iteration strategy for iterative solution-phase synthesis of protected keratan sulfate (KS)-like fragments is reported. Obstacles in a strategy using galactose-glucosamine (Gal-GlcNAc) modules led to the discovery of a differentially protected GlcNAc-Gal module that could be used to synthesize KS-like fragments using a fluorous tag that
Sayantan, Bhaduri, Nicola L B, Pohl
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Keratan Sulfate: Biosynthesis, Structures, and Biological Functions
2014Keratan sulfate is a glycosaminoglycan that has been investigated in the cornea and skeletal tissues for decades. Endoglycosidases and monoclonal antibodies specific for keratan sulfate have been developed. These materials have facilitated the analysis of keratan sulfate biosynthesis and structures. Likewise, they have expedited study of the biological
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Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells
Biochemical and Biophysical Research Communications, 2008Keratan sulfate (KS) proteoglycan is expressed in the extracellular matrix or cell surface in numerous tissues, predominantly in those of the cornea, cartilage, and brain. However, its structure, function, and regulation remain poorly understood. Our investigation of KS expression in glioblastoma cell lines using Western-blot and flow cytometry with ...
Norihito, Hayatsu +4 more
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Immunohistochemical localization of keratan sulfate in the chinchilla inner ear
Hearing Research, 1997Keratan sulfate (KS) was immunolocalized in the chinchilla cochlea and vestibular system using indirect immunohistochemistry and a monoclonal antibody (clone 5-D-4) directed against a proteoglycan core antigen. As a positive control, anti-KS Mab reactivity was found in the pericellular matrix and lacuna walls of temporal bone osteocytes. In the cochlea,
D J, Swartz, P A, Santi
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Structure and biological functions of keratan sulfate proteoglycans
1994The skeletal and corneal keratan sulfate proteoglycans show a different metabolic and structural heterogeneity. The domain structure of the carbohydrate chain has been shown to be different in various animal species. There are two major types of skeletal keratan sulfate proteoglycans with and without fucose.
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Keratan Sulfate Gal-6-Sulfotransferase
2002Keratan sulfate (KS) is composed of the repeating disaccharide unit of Galβ1-4GlcNAc (poly-N-acetyllactosamine) with sulfate groups at the 6-position of the Gal and GlcNAc residues. Most GlcNAc residues and half of the Gal residues of corneal KS are sulfated, suggesting that sulfation of the Gal residue occurs after sulfation of the GlcNAc residue and ...
Masakazu Fukuta, Osami Habuchi
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