Results 211 to 220 of about 10,759 (233)
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Biosynthesis of Keratan Sulfate
2009Keratan sulfate (KS) is a poly-sulfated glycosaminoglycan with a poly-N-acetyllactosamine linear chain structure. KS is a rich component in cornea, and is also present in cartilage and brain. In cornea, KS plays important roles in maintaining water content and developing collagen matrix. Recent studies have demonstrated its association with Alzheimer’s
Akira Seko, Katsuko Yamashita
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Mannose in the Keratan Sulfate from Bovine Cornea
The Journal of Biochemistry, 1982After exhaustive digestion of bovine corneas with a protease, keratan sulfate fractions of different chain length were obtained by ethanol fractionation on a cellulose column, followed by ion-exchange column chromatography. Compositional analysis of these fractions showed that aspartic acid is the predominant amino acid and that the keratan sulfate in ...
Haruki Yamaguchi, Takeshi Nakai
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Identification and quantitation of keratan sulfate in urine
Clinica Chimica Acta, 1974Abstract The purpose of the present artical is to indicate reliable and specific methods for identification and quantitation of keratan sulfate in urine. Thinlayer chromatography on silica gel or cellulose allows rapid and specific characterization, whereas prior isolation on Dowex 1×2 with selective elution with 3.0 M NaCl only allows quantitative ...
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Brain Keratan Sulfate and Glial Scar Formation
Annals of the New York Academy of Sciences, 2006Abstract: In response to injury to the central nervous system (CNS), reactive astrocytes appear and accumulate in the wounded area, leading to glial scar formation. Glial scar is the physical barrier to axonal regeneration of injured neurons. Chondroitin sulfate proteoglycans are inhibitory to axon outgrowth and are upregulated in reactive astrocytes
Haoqian Zhang +2 more
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Keratan sulfate: An up-to-date review
International Journal of Biological Macromolecules, 2015Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry.
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Serum keratan sulfate levels in osteoarthritis patients
Arthritis & Rheumatism, 1988AbstractSerum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more
Christine M. Schnitzler +7 more
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Keratan sulfate exacerbates experimental autoimmune encephalomyelitis
Journal of Neuroscience Research, 2015Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis ...
Rino Ueno +5 more
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Impaired degradation of keratan sulfate in GM1-gangliosidosis
Clinica Chimica Acta, 1982Abstract We have prepared a new radiolabeled substrate (galactose-N-acetylglucosamine 6-sulfate-[1-3H]galactitol), from shark cartilage keratan sulfate, for an assay of acid β-galactosidase activity. Using this substrate, we found that there was a striking deficiency of β-galactosidase activity in the cultured skin fibroblasts of patients with GM1 ...
Okada Shintaro +3 more
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Fluorous-Tag Assisted Syntheses of Sulfated Keratan Sulfate Oligosaccharide Fragments
Organic Letters, 2016The first block iteration strategy for iterative solution-phase synthesis of protected keratan sulfate (KS)-like fragments is reported. Obstacles in a strategy using galactose-glucosamine (Gal-GlcNAc) modules led to the discovery of a differentially protected GlcNAc-Gal module that could be used to synthesize KS-like fragments using a fluorous tag that
Sayantan Bhaduri, Nicola L. B. Pohl
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Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells
Biochemical and Biophysical Research Communications, 2008Keratan sulfate (KS) proteoglycan is expressed in the extracellular matrix or cell surface in numerous tissues, predominantly in those of the cornea, cartilage, and brain. However, its structure, function, and regulation remain poorly understood. Our investigation of KS expression in glioblastoma cell lines using Western-blot and flow cytometry with ...
Norihito Hayatsu +5 more
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