Results 231 to 240 of about 410,791 (266)
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Serum keratan sulfate levels in osteoarthritis patients
Arthritis & Rheumatism, 1988AbstractSerum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more
M B, Sweet +7 more
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Keratan sulfate expression during avian craniofacial morphogenesis
Roux's Archives of Developmental Biology, 1989Using the monoclonal antibody MZ15 in immunocytochemical and ultrastructural studies we have been able to determine the spatiotemporal pattern of keratan sulfate (KS) distribution during quail craniofacial morphogenesis. KS-containing proteoglycans are found associated with invaginating placodes (olfactory, lens and otic), in developing pronephric ...
Lindsay, Heath, Peter, Thorogood
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Biosynthesis of Keratan Sulfate
2009Keratan sulfate (KS) is a poly-sulfated glycosaminoglycan with a poly-N-acetyllactosamine linear chain structure. KS is a rich component in cornea, and is also present in cartilage and brain. In cornea, KS plays important roles in maintaining water content and developing collagen matrix. Recent studies have demonstrated its association with Alzheimer’s
Akira Seko, Katsuko Yamashita
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Keratan Sulfate Gal-6-Sulfotransferase
2002Keratan sulfate (KS) is composed of the repeating disaccharide unit of Galβ1-4GlcNAc (poly-N-acetyllactosamine) with sulfate groups at the 6-position of the Gal and GlcNAc residues. Most GlcNAc residues and half of the Gal residues of corneal KS are sulfated, suggesting that sulfation of the Gal residue occurs after sulfation of the GlcNAc residue and ...
Masakazu Fukuta, Osami Habuchi
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Keratan sulfate in body fluids in joint disease
Acta Orthopaedica Scandinavica, 1995Keratan sulfate (KS) is a highly-negatively charged glycosaminoglycan which is found principally in aggrecan, the most abundant proteoglycan in the extracellular matrix of hyaline, fibrous and elastic cartilage. In 1985, we discovered that small peptidoglycans bearing antigenic KS (agKS) were present in small amounts in human serum and postulated that ...
E J, Thonar +5 more
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Mannose in the Keratan Sulfate from Bovine Cornea
The Journal of Biochemistry, 1982After exhaustive digestion of bovine corneas with a protease, keratan sulfate fractions of different chain length were obtained by ethanol fractionation on a cellulose column, followed by ion-exchange column chromatography. Compositional analysis of these fractions showed that aspartic acid is the predominant amino acid and that the keratan sulfate in ...
H, Yamaguchi, T, Nakai
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The Linkage of Corneal Keratan Sulfate to Protein
Connective Tissue Research, 1975The linkage of corneal keratan sulfate to protein has been investigated. After exhaustive digestion of bovine corneas with papain and pronase, a product was obtained in which aspartic acid was the predominant amino acid and constituted 59% of the total amino acids.
J R, Baker, J A, Cifonelli, L, Rodén
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Biochemistry, 1994
Keratan sulfate chains were isolated from bovine articular cartilage (6-8-year-old animals) and digested with keratanase II, an endo-beta-N-acetylglucosaminidase [Nakazawa, K., Ito, M., Yamagata, T., & Suzuki, S. (1989) in Keratan Sulphate: Chemistry, Biology and Chemical Pathology (Greiling, H., & Scott, J. E., Eds.) pp 99-110, The Biochemical Society,
Brown, Gavin M. +4 more
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Keratan sulfate chains were isolated from bovine articular cartilage (6-8-year-old animals) and digested with keratanase II, an endo-beta-N-acetylglucosaminidase [Nakazawa, K., Ito, M., Yamagata, T., & Suzuki, S. (1989) in Keratan Sulphate: Chemistry, Biology and Chemical Pathology (Greiling, H., & Scott, J. E., Eds.) pp 99-110, The Biochemical Society,
Brown, Gavin M. +4 more
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Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells
Biochemical and Biophysical Research Communications, 2008Keratan sulfate (KS) proteoglycan is expressed in the extracellular matrix or cell surface in numerous tissues, predominantly in those of the cornea, cartilage, and brain. However, its structure, function, and regulation remain poorly understood. Our investigation of KS expression in glioblastoma cell lines using Western-blot and flow cytometry with ...
Norihito, Hayatsu +4 more
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Journal of Pharmaceutical and Biomedical Analysis, 2021
Q. Ren +11 more
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Q. Ren +11 more
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