Results 81 to 90 of about 6,637 (212)

N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity

, 2005
Keratan sulfate is thought to influence the cleavage of aggrecan by metalloenzymes. We have therefore produced a recombinant substrate, substituted with keratan sulfate, suitable for the study of aggrecanolysis in vitro.
Fosang, AJ, Keene, DR, McQuillan, DJ, Poon, CJ, Last, K, Plaas, AH   +5 more
core   +1 more source

SERUM KERATAN SULFATE LEVEL FOLLOWING CHEMONUCLEOLYSIS [PDF]

, 1991
In chemonucleolysis, accuracy of injection can be in doubt if the patient fails to respond. Discography preceding chemonucleolysis is associated with increased neurologic complications.
Kernohan, George, ROBERTS, G, TRIMBLE, ER, ADAIR, IV, MURALIKUTTAN, KP, MOLLAN, RAB   +5 more
core   +1 more source

Quantification of keratan sulfate in blood as a marker of cartilage catabolism [PDF]

Arthritis & Rheumatism, 1985
AbstractWe have developed an enzyme‐linked immunosorbent‐inhibition assay which makes use of a monoclonal antibody specific for keratan sulfate to quantify keratan sulfate present as single chains in adult human serum. In adults hospitalized with conditions not thought to affect the turnover of keratan sulfate‐containing tissues, the serum levels ...
E J, Thonar, M E, Lenz, G K, Klintworth, B, Caterson, L M, Pachman, P, Glickman, R, Katz, J, Huff, K E, Kuettner   +8 more
openaire   +2 more sources

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

Distribution of keratan sulfate in cartilage proteoglycans.

Journal of Biological Chemistry, 1977
After chondroitinase digestion of bovine nasal and tracheal cartilage proteoglycans, subsequent treatment with trypsin or trypsin followed by chymotrypsin yielded two major types of polypeptide-glycosaminoglycan fragments which could be separated by Sepharose 6B chromatography.
D, Heinegård, I, Axelsson
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, Volume 20, Issue 2, Page 260-281, February 2026.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Urinary keratan sulfate of Morquio's disease.

The Tohoku Journal of Experimental Medicine, 1980
To elucidate precise chemical nature of urinary keratan sulfate (KS) of Morquio's disease, crude glycosaminoglycans (GAG) were separated from 24-hr urines of 3 patients with Morquio's disease and from pooled urine of a healthy boy, using cetylpyridinium chloride.
NAMIKI, OSAMU, MASUBUCHI, MASAAKI, TOYOSHIMA, HIROMICHI, ENDO, MASAHIKO, YOSIZAWA, ZENSAKU   +4 more
openaire   +3 more sources

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Isoforms of corneal keratan sulfate proteoglycan.

Journal of Biological Chemistry, 1990
Bovine corneal keratan sulfate proteoglycan was found to contain three major protein components. Two proteins (37 and 25 kDa) were released from the proteoglycan by endo-beta-galactosidase, N-glycanase, or chemical deglycosylation. A smaller protein (20 kDa), not covalently linked to keratan sulfate, co-purified with the proteoglycan by conventional ...
J L, Funderburgh, G W, Conrad
openaire   +2 more sources

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, Volume 293, Issue 3, Page 709-728, February 2026.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source