Results 61 to 70 of about 5,745 (171)
Aggrecan structure in amphibian cartilage
Brazilian Journal of Medical and Biological Research, 2000 The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14.
Covizi D.Z., Carvalho H.F.
doaj
Comparison of ABBV‐552 Safety and Pharmacokinetics in Healthy Asian and Western Adults
Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.Abstract ABBV‐552, a positive modulator of synaptic vesicle glycoprotein 2A (SV2A), was under investigation as a treatment for cognitive impairment related to Alzheimer's disease. This Phase 1, multicenter, open‐label, parallel cohort study (NCT05686980) was conducted to examine the pharmacokinetics (PK), safety, and tolerability of ABBV‐552 in healthy
Nick Miles +5 more
wiley +1 more source
Keratan Sulfate in Neuronal Network Reconstruction
Trends in Glycoscience and Glycotechnology, 2011 ケラタン硫酸は2糖の繰り返し構造を単位とするグリコサミノグリカンの一つであり、コアプロテインに共有結合することによりケラタン硫酸プロテオグリカンを生ずる。ケラタン硫酸プロテオグリカンは元来角膜抽出物において発見され、また関節軟骨中において豊富に見出されたため、これら組織における構造や生物学的機能が注目されてきた。しかし1980年代に入り中枢神経系においても見出され、神経系の発達や疾患における働きが注目を集めてきた。現在、ケラタン硫酸プロテオグリカンは生理的および損傷後神経可塑性を制御する主要な分子の一つとして受け入れられ始めている。
Sakamoto, Kazuma, Kadomatsu, Kenji
openaire +2 more sources
R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking
Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar +7 more
wiley +1 more source
Quantification of keratan sulfate in blood as a marker of cartilage catabolism [PDF]
Arthritis & Rheumatism, 1985 AbstractWe have developed an enzyme‐linked immunosorbent‐inhibition assay which makes use of a monoclonal antibody specific for keratan sulfate to quantify keratan sulfate present as single chains in adult human serum. In adults hospitalized with conditions not thought to affect the turnover of keratan sulfate‐containing tissues, the serum levels ...
E J, Thonar +8 more
openaire +2 more sources
JIMD Reports, Volume 67, Issue 4, July 2026.ABSTRACT Enzyme replacement therapy (ERT) with elosulfase alfa is the only approved treatment for mucopolysaccharidosis type IVA. This case report delineates the 5‐year outcomes of ERT in two Korean siblings with mucopolysaccharidosis type IVA, with the younger sibling initiating treatment at 0.8 years of age and the older one at 5.4 years.
Shinjie Choi +3 more
wiley +1 more source
Distribution of keratan sulfate in cartilage proteoglycans.
Journal of Biological Chemistry, 1977 After chondroitinase digestion of bovine nasal and tracheal cartilage proteoglycans, subsequent treatment with trypsin or trypsin followed by chymotrypsin yielded two major types of polypeptide-glycosaminoglycan fragments which could be separated by Sepharose 6B chromatography.
D, Heinegård, I, Axelsson
openaire +2 more sources
Hyaluronan (HA) Receptors: Discovery, Function & Pathology
Proteoglycan Research, Volume 4, Issue 3, July 2026.ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp +8 more
wiley +1 more source
Urinary keratan sulfate of Morquio's disease.
The Tohoku Journal of Experimental Medicine, 1980 To elucidate precise chemical nature of urinary keratan sulfate (KS) of Morquio's disease, crude glycosaminoglycans (GAG) were separated from 24-hr urines of 3 patients with Morquio's disease and from pooled urine of a healthy boy, using cetylpyridinium chloride.
NAMIKI, OSAMU +4 more
openaire +3 more sources
The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki +4 more
wiley +1 more source