Results 61 to 70 of about 6,637 (212)
Keratan Sulfate Promotes Periodontitis Progression Via Tlr4/Nf-Κb Pathway
International Dental JournalAim or purpose: To explore the metabolic level and regulatory mechanism of keratan sulfate (KS) in periodontitis progression. Materials and methods: KS secretion levels and FUT8 and CHST2 expression, alongside neutrophil and plasma cell infiltration ...
Ziqin Zhao +3 more
doaj +1 more source
Enzyme replacement in a human model of mucopolysaccharidosis IVA in vitro and its biodistribution in the cartilage of wild type mice. [PDF]
PLoS ONE, 2010 Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfatase (GALNS), an enzyme that degrades keratan sulfate (KS). Currently no therapy for MPS IVA is available.
Melita Dvorak-Ewell +7 more
doaj +1 more source
The role of transforming growth factor-beta in keratan sulfate metabolism in rabbit articular chondrocytes [PDF]
, 1993 Keratan sulfate is the specific molecule in glycosaminoglycan, which is the matrix of articular cartilage, and is produced by chondrocytes. There is evidence that levels of serum keratan sulfate might reflect turnover of articular cartilage in vivo.
大谷, 和裕, Ohtani, Kazuhiro
core
Selective loss of cerebral keratan sulfate in Alzheimer's disease
, 1996 Proteoglycans, especially heparan sulfate-substituted species, are known to be associated with the deposition of amyloid in Alzheimer's disease, We previously found that heparan sulfate from afflicted brains, and from control subjects, differed minimally
Eriksson, Lars, +4 more
core +1 more source
Advanced Functional Materials, Volume 36, Issue 40, 18 May 2026.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production
BMC Biotechnology, 2008 Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen
Norton H James +6 more
doaj +1 more source
Histamine H2 receptor mediates keratan sulfate secretion in rabbit chondrocytes: role of cAMP
, 1993 We obtained evidence for the presence of a single class of histamine H2 receptor on rabbit chondrocytes. Stimulation of these receptors with specific H2 agonists led to an inhibition of keratan sulfate secretion and rapid (15 min) accumulation of ...
K. Fukuda, F. Matsumura, S. Tanaka
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Brain and Behavior, Volume 16, Issue 5, May 2026.Causal links identified between five inflammatory proteins, 22 immune cell types, and subarachnoid hemorrhage (SAH) via Mendelian randomization. Multi‐omics integration (pQTL, eQTL) revealed regulatory mechanisms underlying inflammation in SAH. FGF23 and CD4 Tregs emerged as key therapeutic targets, supported by colocalization and replication analysis.
Xingjie Shi +8 more
wiley +1 more source
Molecular Therapy: Methods & Clinical DevelopmentMucopolysaccharidosis type IVA (MPS IVA) is caused by a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS), leading to the accumulation of keratan sulfate and chondroitin-6-sulfate and development of severe skeletal dysplasia.
Shaukat A. Khan +4 more
doaj +1 more source
Dimethylmethylene Blue Assay (DMMB)
Bio-Protocol, 2014 Glycosaminoglycans (GAGs) are long unbranched polysaccharides consisting of repeating disaccharide units composed of a hexosamine (glucosamine or galactosamine) and a hexuronic acid (glucuronic or iduronic acid).
Vivien Coulson-Thomas, Tarsis Ferreira
doaj +1 more source