Results 51 to 60 of about 6,637 (212)

Demonstration of a keratan sulfate-containing proteoglycan in atherosclerotic aorta.

, 1992
Proteoglycans were isolated from either grossly normal or atherosclerotic pigeon aortas after extraction with 4 M guanidine hydrochloride and purification by ion-exchange and size-exclusion chromatography.
T C Register, B Caterson, W D Wagner, R A Robbins   +3 more
core   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar, Alexander Lin, Abigail E. Reeves, Meg Critcher, Gil‐Suk Yang, Sean Hui, Daved H. Fremont, Mia L. Huang   +7 more
wiley   +1 more source

Long-Term Liver-Targeted AAV8 Gene Therapy for Mucopolysaccharidosis IVA

Current Issues in Molecular Biology
Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease with an autosomal recessive trait caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which leads to the accumulation of chondroitin-6-sulfate and ...
Shaukat A. Khan, Eliana Benincore-Florez, FNU Nidhi, Jose Victor Álvarez, Dione A. Holder, Shunji Tomatsu   +5 more
doaj   +1 more source

The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics

Microorganisms, 2017
Glycosaminoglycans (GAGs) are sulfated glycans capable of regulating various biological and medical functions. Heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate and hyaluronan are the principal classes of GAGs found in ...
Ariana A. Vasconcelos, Vitor H. Pomin
doaj   +1 more source

Distribution and Function of Glycosaminoglycans and Proteoglycans in the Development, Homeostasis and Pathology of the Ocular Surface

Frontiers in Cell and Developmental Biology, 2020
The ocular surface, which forms the interface between the eye and the external environment, includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that produce the tear film.
Sudan Puri, Yvette M. Coulson-Thomas, Tarsis F. Gesteira, Tarsis F. Gesteira, Vivien J. Coulson-Thomas   +4 more
doaj   +1 more source

Iron oxide-coupled CRISPR-nCas9-based genome editing assessment in mucopolysaccharidosis IVA mice

Molecular Therapy: Methods & Clinical Development, 2023
Mucopolysaccharidosis (MPS) IVA is a lysosomal storage disorder caused by mutations in the GALNS gene that leads to the lysosomal accumulation of keratan sulfate (KS) and chondroitin 6-sulfate, causing skeletal dysplasia and cardiopulmonary complications.
Andrés Felipe Leal, Betul Celik, Nidhi Fnu, Shaukat Khan, Shunji Tomatsu, Carlos Javier Alméciga-Díaz   +5 more
doaj   +1 more source

Secretion of corneal keratan sulfate proteoglycans by pellet cultures.

, 2013
Proteoglycans were isolated from culture medium before (Lanes 1,2,5,6) or after (3,4,7,8) three-week incubation with hES pellets. The proteoglycan fractions were biotin- labeled and immune-precipitated with antibodies against keratocan (anti-Kera) (lanes
Katherine A. Davoli (380733), Mary M. Mann (42052), Lei Yang (102719), Yiqin Du (380732), Jocelyn Danielle Mich-Basso (116838), Martha L. Funderburgh (42051), James L. Funderburgh (42053), Andrew J. Hertsenberg (380731), Audrey A. Chan (380730)   +8 more
core   +1 more source

Immunolocalization of Keratan Sulfate Proteoglycan in Rat Calvaria.

Archives of Histology and Cytology, 2001
We investigate, by the immunogold method, the localization of keratan sulfate (KS) proteoglycan in rat calvaria in order to clarify the detailed process of intramembranous ossification. KS was localized in bone nodules corresponding to calcified nodules, close to the saggital suture of calvaria. The immunoreactivity decreased in fully calcified regions
NAKAMURA, Hiroaki, HIRATA, Azumi, TSUJI, Takehito, YAMAMOTO, Toshio   +3 more
openaire   +3 more sources

Preclinical Efficacy and Safety Study of a Novel Dermal Fibroblast Modulating Drug, SLI‐F06, in Cutaneous Wound Healing

MedComm, Volume 7, Issue 6, June 2026.
A novel, chemically synthesized fibromodulin (FMOD)‐derived peptide, SLI‐F06, has been developed to significantly improve scar appearance, tensile strength, and histological outcomes among multiple preclinical animal models. Demonstrating no genotoxicity or systemic/local toxicity, SLI‐F06 has received United States Food and Drug Administration ...
Zhong Zheng, Pin Ha, Chenshuang Li, Grace Xinlian Chang, Wenlu Jiang, Xiaoxiao Pang, Zhaohan Zeng, Elisabeth Leeflang, Kang Ting, Chia Soo   +9 more
wiley   +1 more source