Results 41 to 50 of about 6,637 (212)

The role of aggrecan in normal and osteoarthritic cartilage

Journal of Experimental Orthopaedics, 2014
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj   +1 more source

Preparation of the Partially Methylated Alditol Acetates Derived from CS Tetrasaccharides Containing Galactose for the Gas Chromatography/Mass Spectrometry Analysis

Bio-Protocol, 2017
Chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of carbohydrates, is composed of linear, sulfated repeating disaccharide sequences of N-acetyl-D-galactosamine (GalNAc) and glucuronic acid (GlcA).
Kyohei Higashi, Toshihiko Toida
doaj   +1 more source

Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Blood–brain barrier disruption is increasingly recognized in synucleinopathies, but the role of the endothelial glycocalyx (GLX) in Parkinson's disease (PD) and multiple system atrophy (MSA) remains unclear. Objectives The aim was to determine whether plasma GLX markers differ between PD, MSA, and healthy controls (HC), relate to ...
Jonas Folke, Brian DellaValle, Mathias Lindh Jørgensen, Phillip Bredahl Mogensen, Casper Hempel, Jørgen Rungby, Anne‐Mette Hejl, Annemette Løkkegaard, Lisette Salvesen, Sara Bech, Mette Møller, Erik Hvid Danielsen, Morten Blaabjerg, Matthias Bode, Tomasz Brudek, Susana Aznar   +15 more
wiley   +1 more source

Mucin-like glycopolymer gels in electrosensory tissues generate cues which direct electrolocation in amphibians and neuronal activation in mammals

Neural Regeneration Research, 2019
Mucin-like glycoproteins have established roles in epithelial boundary protection and lubricative roles in some tissues. This mini-review illustrates alternative functional roles which rely on keratan sulphate and sialic acid modifications to mucin ...
James Melrose
doaj   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Axonal pathfinding during the development of the nervous system

Annals of the Child Neurology Society, 2023
Guidance of axons sprouting from maturing neuroblasts, during intermediate trajectories and in seeking target neurons for synaptogenesis, is a fundamental developmental process in central nervous system maturation.
Harvey B. Sarnat
doaj   +1 more source

Disaccharide composition of keratan sulfate (KS) disaccharides in the spine and limb.

, 2023
Disaccharide composition of keratan sulfate (KS) disaccharides in the spine and limb.
Tsukasa Yonekura (15285878), Tadashi Okubo (4225), Shuhei Yamada (2501758), Soichiro Saito (15285875), Shuji Mizumoto (3154707), Tatsuya Furuichi (180107), Rina Yamashita (15285881), Tadashi Okamura (118212), Kenta Nakano (8939417)   +8 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

GAG-DB, the New Interface of the Three-Dimensional Landscape of Glycosaminoglycans

Biomolecules, 2020
Glycosaminoglycans (GAGs) are complex linear polysaccharides. GAG-DB is a curated database that classifies the three-dimensional features of the six mammalian GAGs (chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan ...
Serge Pérez, François Bonnardel, Frédérique Lisacek, Anne Imberty, Sylvie Ricard Blum, Olga Makshakova   +5 more
doaj   +1 more source

Increased migratory activity and cartilage regeneration by superficial-zone chondrocytes in enzymatically treated cartilage explants

BMC Musculoskeletal Disorders, 2022
Background Limited chondrocyte migration and impaired cartilage-to-cartilage healing is a barrier in cartilage regenerative therapy. Collagenase treatment and delivery of a chemotactic agent may play a positive role in chondrocyte repopulation at the ...
Yuichiro Shiromoto, Yasuo Niki, Toshiyuki Kikuchi, Yasuo Yoshihara, Takemi Oguma, Koichi Nemoto, Kazuhiro Chiba, Arihiko Kanaji, Morio Matsumoto, Masaya Nakamura   +9 more
doaj   +1 more source