Results 31 to 40 of about 5,745 (171)
Residual keratan sulfate in chondroitin sulfate formulations for oral administration
Carbohydrate Polymers, 2012 Chondroitin sulfate is a biomedical glycosaminoglycan (GAG) mostly used as a dietary supplement. We undertook analysis on some formulations of chondroitin sulfates available for oral administration. The analysis was based on agarose-gel electrophoresis, strong anion-exchange chromatography, digestibility with specific GAG lyases, uronic acid content ...
Pomin, Vitor H. +3 more
openaire +2 more sources
Characterization and Determination of Human Urinary Keratan Sulfate.
Chemical and Pharmaceutical Bulletin, 1998 Keratan sulfate was isolated from normal human urine and was characterized by sugar compositional analysis and H-NMR spectroscopy. It was found that KS from human urine is classified as skeletal type (KS-II type chain) with an O-glycosidic linkage between galactosamine and serine (or threonine).
TOYODA, Hidenao +5 more
openaire +3 more sources
Sulodexide. Nephroprotective properties and horizons for use in nephrology
Медицинский совет, 2015 Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj +1 more source
Journal of Craniovertebral Junction and Spine, 2020 Morquio syndrome (MS) is an autosomal recessive defect caused by the deficiency of N-acetylgalactosamine-6-sulfatase. Odontoid hypoplasia, periodontoid soft tissue deposition, and cervical stenosis lead to myelopathy and quadriparesis in these patients ...
Suyash Singh +4 more
doaj +1 more source
The role of aggrecan in normal and osteoarthritic cartilage
Journal of Experimental Orthopaedics, 2014 Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj +1 more source
Bio-Protocol, 2017 Chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of carbohydrates, is composed of linear, sulfated repeating disaccharide sequences of N-acetyl-D-galactosamine (GalNAc) and glucuronic acid (GlcA).
Kyohei Higashi, Toshihiko Toida
doaj +1 more source
Neural Regeneration Research, 2019 Mucin-like glycoproteins have established roles in epithelial boundary protection and lubricative roles in some tissues. This mini-review illustrates alternative functional roles which rely on keratan sulphate and sialic acid modifications to mucin ...
James Melrose
doaj +1 more source
Axonal pathfinding during the development of the nervous system
Annals of the Child Neurology Society, 2023 Guidance of axons sprouting from maturing neuroblasts, during intermediate trajectories and in seeking target neurons for synaptogenesis, is a fundamental developmental process in central nervous system maturation.
Harvey B. Sarnat
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Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, EarlyView.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2022 Background Limited chondrocyte migration and impaired cartilage-to-cartilage healing is a barrier in cartilage regenerative therapy. Collagenase treatment and delivery of a chemotactic agent may play a positive role in chondrocyte repopulation at the ...
Yuichiro Shiromoto +9 more
doaj +1 more source