Results 71 to 80 of about 6,637 (212)

Enzymatic sulfation of galactose residue of keratan sulfate by chondroitin 6-sulfotransferase [PDF]

Glycobiology, 1996
We have previously found that the purified chondroitin 6-sulfotransferase (C6ST), which transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of N-acetylgalactosamine in chondroitin, catalyzed the sulfation of keratan sulfate, and that both the C6ST activity and the keratan sulfate sulfotransferase (KSST) activity were ...
O, Habuchi, Y, Hirahara, K, Uchimura, M, Fukuta   +3 more
openaire   +2 more sources

Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Mark Wijnen, Evert F. S. van Velsen, J. Gert‐Jan Milhous, Esmee Oussoren, Bram C. J. van der Eerden, Margreet A. E. M. Wagenmakers   +5 more
wiley   +1 more source

Human Keratinocytes Contain Carbohydrates That Are Recognized by Keratan Sulfate – Specific Monoclonal Antibodies

, 1990
Monoclonal antibodies that recognize carbohydrate epitopes found in keratan sulfate glycosaminoglycan chains identified both intracytoplasmic and cell-surface carbohydrates of human keratinocytes.
Davis, Bryan, Sorrell, J Michael, Caterson, Bruce, Schafer, Irwin A, Caplan, Arnold I   +4 more
core   +1 more source

Collagen organisation in the fibrous joint capsules in the digits of the human hand

Journal of Anatomy, Volume 248, Issue 4, Page 612-623, April 2026.
The function of the finger joints is important for daily life. In this review of the literature, we consider the role of collagen and its organization within the fibrous finger joint capsules of the interphalangeal (IP) joints and investigate the relationships between collagen orientation and joint function. Abstract Normal function of the hand and, in
Fiona R. Saunders, Ronald G. Coutts, Richard M. Aspden, Flora Gröning   +3 more
wiley   +1 more source

Chemical and metabolic heterogeneity of chondroitin sulfate and keratan sulfate in guinea pig cartilage and nucleus pulposus

, 1973
Chondroitin sulfate and keratan sulfate in guinea pig costal cartilage, nasal septum cartilage and nucleus pulposus were separated and fractionated by chromatography on CPC-cellulose, ECTEOLA-cellulose and Sephadex G-200 columns.
Antonopoulos, Christos A., Lohmander, Stefan, Friberg, Ulf   +2 more
core   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Aggrecan structure in amphibian cartilage

Brazilian Journal of Medical and Biological Research, 2000
The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14.
Covizi D.Z., Carvalho H.F.
doaj  

Chondroitin, Dermatan, Heparan, and Keratan Sulfate: Structure and Functions

, 2019
Sulfated glycosaminoglycans (heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate) are a family of complex polysaccharides ubiquitously, but not exclusively, distributed among mammals, found both in extracellular matrices and on
Maria Michela Corsaro, Alfonso Iadonisi, Corsaro, M. M., Fernández-Mayoralas, Alfonso, Iadonisi, Alfonso, Emiliano Bedini, Alfonso Fernández-Mayoralas, Bedini, Emiliano   +7 more
core   +1 more source

Keratan Sulfate in Neuronal Network Reconstruction

Trends in Glycoscience and Glycotechnology, 2011
ケラタン硫酸は2糖の繰り返し構造を単位とするグリコサミノグリカンの一つであり、コアプロテインに共有結合することによりケラタン硫酸プロテオグリカンを生ずる。ケラタン硫酸プロテオグリカンは元来角膜抽出物において発見され、また関節軟骨中において豊富に見出されたため、これら組織における構造や生物学的機能が注目されてきた。しかし1980年代に入り中枢神経系においても見出され、神経系の発達や疾患における働きが注目を集めてきた。現在、ケラタン硫酸プロテオグリカンは生理的および損傷後神経可塑性を制御する主要な分子の一つとして受け入れられ始めている。
Sakamoto, Kazuma, Kadomatsu, Kenji
openaire   +2 more sources

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source