Results 11 to 20 of about 25,295 (209)

Ketoconazole as second-line treatment for Cushing’s disease after transsphenoidal surgery: systematic review and meta-analysis

Frontiers in Endocrinology, 2023
IntroductionThe first-line treatment for Cushing’s disease is transsphenoidal surgery for pituitary tumor resection. Ketoconazole has been used as a second-line drug despite limited data on its safety and efficacy for this purpose.
Camila Viecceli, Ana Carolina Viana Mattos, Vânia Naomi Hirakata, Sheila Piccoli Garcia, Ticiana da Costa Rodrigues, Ticiana da Costa Rodrigues, Ticiana da Costa Rodrigues, Mauro Antônio Czepielewski, Mauro Antônio Czepielewski, Mauro Antônio Czepielewski   +9 more
doaj   +1 more source

Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets [PDF]

Journal of the Serbian Chemical Society, 2005
The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25ºC at a constant ionic strength of M(NaCl).
Vojić Mirjana P., Popović Gordana V., Sladić Dušan M., Pfendt Lidija B.   +3 more
doaj   +3 more sources

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

Pharmaceuticals, 2023
To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely ...
Hongmei Yu, Li Zhang, Meiju Liu, Dezhi Yang, Guorong He, Baoxi Zhang, Ningbo Gong, Yang Lu, Guanhua Du   +8 more
doaj   +1 more source

Evaluation of the efficacy and safety of ionic liquids containing ketoconazole in patients with tinea pedis: A randomized controlled clinical trial

Bioengineering & Translational Medicine, 2023
Ionic liquids (ILs) loading ketoconazole (KCZ) have shown better efficacy on rats with tinea pedis than the marketed Daktarin® but clinical studies are still lacking.
Xiying Wu, Min Shen, Huan Wang, Xue He, Jingwen Tan, Ruiping Wang, Lianjuan Yang, Hong Yang, Jianping Qi, Zhongjian Chen, Quangang Zhu   +10 more
doaj   +1 more source

Study the Antifungal and Ocular Permeation of Ketoconazole from Ophthalmic Formulations Containing Trans-Ethosomes Nanoparticles

Pharmaceutics, 2021
Ketoconazole (KET), a synthetic imidazole broad-spectrum antifungal agent, is characterized by its poor aqueous solubility and high molecular weight, which might hamper its corneal permeation.
Tarek A. Ahmed, Maram M. Alzahrani, Alaa Sirwi, Nabil A. Alhakamy   +3 more
doaj   +1 more source

Qualitative and quantitative assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC

Journal of Pharmaceutical Analysis, 2019
Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol ...
Wenling Yang, Xiaomei Yang, Fanghua Shi, Zhigang Liao, Yongkun Liang, Liangzhong Yu, Ruixun Wang, Qing Li, Kaishun Bi   +8 more
doaj   +1 more source

Evaluation of ketoconazole as a treatment for Cushing’s disease in a retrospective cohort

Frontiers in Endocrinology, 2022
ObjectiveThe first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission.
Camila Viecceli, Camila Viecceli, Ana Carolina Viana Mattos, Maria Carolina Bittencourt Costa, Rafael Borba de Melo, Ticiana da Costa Rodrigues, Ticiana da Costa Rodrigues, Ticiana da Costa Rodrigues, Mauro Antonio Czepielewski, Mauro Antonio Czepielewski, Mauro Antonio Czepielewski   +10 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

EVALUATION OF ANTICANDIDAL EFFECTS OF ESSENTIAL OILS OF COMMERCIAL LAVENDER (Lavandula angustifolia Miller) IN COMBINATION WITH KETOCONAZOLE AGAINTS SOME Candida Berkhout STRAINS

Trakya University Journal of Natural Sciences, 2020
Application of combination studies with essential oils and standard antifungal drugs may reduce adverse effects of synthetic drugs and serve as alternative approach against various pathologies including candidiasis.
Fatih Demirci, Gamze Göger, Burcu Akçal Çomoğlu, Gökalp İşcan   +3 more
doaj   +1 more source

High-Performance Liquid Chromatography for Ultra-Simple Determination of Plasma Voriconazole Concentration

Journal of Fungi, 2022
Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu, Yuka Nomura, Yoshito Gando, Yasuhiko Matsumoto, Takashi Sugita, Nobuharu Kosugi, Masayuki Kobayashi   +6 more
doaj   +1 more source