Results 21 to 30 of about 57,314 (316)

A novel mechanism of action of ketoconazole: inhibition of the NorA efflux pump system and biofilm formation in multidrug-resistant Staphylococcus aureus

open access: yesInfection and Drug Resistance, 2019
Background: The rapid emergence of antimicrobial resistance among Gram-positive organisms, especially staphylococci, has become a serious clinical challenge.
R. A. Abd El-Baky   +4 more
semanticscholar   +1 more source

Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent [PDF]

open access: yes, 2017
This paper reports the MEPS-HPLC-DAD method for the simultaneous determination of 12 azole drugs (bifonazole, butoconazole, clotrimazole, econazole, itraconazole, ketoconazole, miconazole, posaconazole, ravuconazole, terconazole, tioconazole and ...
Campestre, Cristina   +9 more
core   +1 more source

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]

open access: yes, 2019
Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni   +6 more
core   +2 more sources

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

open access: yesPharmaceuticals, 2023
To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely ...
Hongmei Yu   +8 more
doaj   +1 more source

Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]

open access: yes, 2014
Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle   +2 more
core   +2 more sources

DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING ANALYTICAL METHOD FOR SIMULTANEOUS DETERMINATION OF DRUGS EMPLOYED IN CANINE LEISHMANIASIS TREATMENT

open access: yesDrug Analytical Research, 2020
We developed and validated a stability-indicating method for the simultaneous determination of allopurinol and ketoconazole in the pharmaceutical form of capsules. A Dionex® liquid chromatograph equipped with a diode array detector (DAD) and InertSustain®
Patrícia Espinosa dos Santos   +3 more
doaj   +1 more source

Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review

open access: yesDermatologic Therapy, 2019
Androgenetic alopecia (AGA) is common and associated with significant psychosocial distress. Treatment options are needed for patients that do not adequately respond to first line treatments of finasteride or minoxidil.
Jaime R. Fields   +3 more
semanticscholar   +1 more source

The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome [PDF]

open access: yes, 2019
When hypertension, a pathology that is frequently found in the general population, presents in a young patient, secondary causes such as Cushing's syndrome (CS), a rare disease characterized by long-term elevated cortisol levels, should be considered ...
Barbot, Mattia   +2 more
core   +1 more source

A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery

open access: yesAutophagy, 2019
Ketoconazole is a broad-spectrum antifungal agent, which has recently been characterized as a potential anticancer agent in several cancer types. However, the molecular mechanism underlying the anticancer effect of ketoconazole is not clearly defined ...
Haining Chen   +4 more
semanticscholar   +1 more source

Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome

open access: yesFrontiers in Endocrinology, 2022
IntroductionTwenty-four-hour urinary free cortisol (24h-UFC) is the most used test for follow-up decision-making in patients with Cushing syndrome (CS) under medical treatment.
Arturo Vega-Beyhart   +17 more
doaj   +1 more source

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