Results 31 to 40 of about 25,521 (211)

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Role of Topical Ketoconazole in Therapeutic Hair Care Beyond Seborrhoeic Dermatitis and Dandruff

JEADV Clinical Practice
Ketoconazole shampoo has well‐documented consistent efficacy and safety in treating dandruff and seborrhoeic dermatitis (SD) when compared to other active antidandruff ingredients such as selenium sulphide, corticosteroids and zinc pyrithione.
Aditya K. Gupta, Piet De Doncker, Mesbah Talukder   +2 more
doaj   +1 more source

Enhancement of ketoconazole dissolution rate by the liquisolid technique

Acta Pharmaceutica, 2018
The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier ...
Molaei Mir-Ali, Osouli-Bostanabad Karim, Adibkia Khosro, Shokri Javad, Asnaashari Solmaz, Javadzadeh Yousef   +5 more
doaj   +1 more source

Ketoconazole Foam ??? Connetics

Drugs in R & D, 2003
Connetics Corporation (USA) is developing a foam formulation of 2% ketoconazole [Extina] for the treatment of mycoses and dermatological indications, particularly seborrhoeic dermatitis. The product utilises Connetics' proprietary foam drug delivery technology, VersaFoam, and is currently awaiting registration in the US for the treatment of seborrhoeic
openaire   +2 more sources

Optimal model‐based design of experiments for parameter precision: Supercritical extraction case

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from flowers. A parameter‐distributed model consisting of a set of partial differential equations is used to describe the governing mass transfer phenomena in a cylindrical packed bed with solid chamomile particles under supercritical conditions using carbon dioxide as a solvent ...
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

Statistical Discrimination of Urinary Steroid Biomarkers in the Athlete Biological Passport: A Novel Approach to an Abnormal Steroid Profile Score (ASPS)

Drug Testing and Analysis, EarlyView.
The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker, Jim E. Griffin, Matthew N. Fedoruk, Laura A. Lewis   +3 more
wiley   +1 more source

Changes in cytochrome P450 gene expression and enzyme activity induced by xenobiotics in rabbits in vivo and in vitro

World Rabbit Science, 2017
As considerable inter-species differences exist in xenobiotic metabolism, developing new pharmaceutical therapies for use in different species is fraught with difficulties.
Orsolya Palócz, Orsolya Farkas, Paul Clayton, György Csikó   +3 more
doaj   +1 more source

Utilization of alginate with gum acacia/pectin/carrageenan as precipitation inhibitor to improve bioavailability in drug supersaturation: A case study of ketoconazole

Carbohydrate Polymer Technologies and Applications, 2023
Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine.
Viviane Annisa, Teuku Nanda Saifullah Sulaiman, Akhmad Kharis Nugroho, Agung Endro Nugroho   +3 more
doaj   +1 more source

Visible Photosensitizing Disinfectant Spray for Combating Multidrug‐Resistant Candidozyma Auris in Healthcare Settings

Exploration, EarlyView.
We designed and synthesized a dual‐type AIE photosensitizer (named TB) spray, containing a cationic quaternary ammonium unit and a glycosyl‐targeted boronic acid moiety, characterized for the elimination of biofilm infections of Candidozyma auris (C. auris) on high‐touch surfaces.
Xiaoyu Xu, Ming‐Yu Wu, Baoping Li, Jie Li, Siyu Chen, Luojia Chen, Donghu Yu, Liupiaopiao Yang, Ziyu Hong, Huaqin Pan, Wei Xiang, Shun Feng, Jong Seung Kim, Lianrong Wang, Zhiqiang Li, Shi Chen, Meijia Gu   +16 more
wiley   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source