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Ketone bodies and the heart. [PDF]
Arch Med Sci Atheroscler Dis, 2021 Ketone bodies are low chain organic substances with four carbon atoms, with β-hydroxybutyric acid and acetone being the main ketone bodies in blood circulation.
Papazafiropoulou AK +2 more
europepmc +4 more sources
Ketone Bodies in Diabetes Mellitus: Friend or Foe? [PDF]
Nutrients, 2023 In glucose-deprived conditions, ketone bodies are produced by the liver mitochondria, through the catabolism of fatty acids, and are used peripherally, as an alternative energy source.
Veneti S +4 more
europepmc +2 more sources
Ketone bodies: from enemy to friend and guardian angel
BMC Medicine, 2021 During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the major source of energy.
Hubert Kolb +5 more
doaj +2 more sources
Ketone bodies: A double-edged sword for mammalian life span. [PDF]
Aging Cell, 2023 Accumulating evidence suggests health benefits of ketone bodies, and especially for longevity. However, the precise role of endogenous ketogenesis in mammalian life span, and the safety and efficacy of the long‐term exogenous supplementation of ketone ...
Tomita I +11 more
europepmc +2 more sources
Nonalcoholic fatty liver disease, circulating ketone bodies and all-cause mortality in a general population-based cohort [PDF]
European Journal of Clinical Investigation, 2021 Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of ...
Bakker, Stephan J. L. +9 more
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Regulation of adult stem cell function by ketone bodies [PDF]
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore
Ole Emil Andersen +5 more
doaj +2 more sources
Measuring ketone bodies for the monitoring of pathologic and therapeutic ketosis
Obesity Science & Practice, 2021 Background The ketone bodies β‐hydroxybutyrate (BOHB) and acetone are generated as a byproduct of the fat metabolism process. In healthy individuals, ketone body levels are ∼0.1 mM for BOHB and ∼1 part per million for breath acetone (BrAce). These levels
Joseph C. Anderson +3 more
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Frontiers in Molecular Neuroscience, 2021 Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological conditions such as diabetes.
Darío García-Rodríguez +1 more
doaj +2 more sources
Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue. [PDF]
Int J Mol Sci, 2023 The increased metabolic activity of the heart as a pump involves a high demand of mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical activities accomplished mainly via oxidative phosphorylation, supplying up to 95% of
Manolis AS, Manolis TA, Manolis AA.
europepmc +2 more sources
Oxaloacetate and Ketone Bodies Synergistically Promote Myoblast Differentiation in L6 Cells [PDF]
MoleculesMalnutrition and aging are major factors that inhibit myoblast differentiation, leading to a decline in muscle function and contributing to sarcopenia development.
Yuji Onuki +4 more
doaj +2 more sources