Results 21 to 30 of about 4,666,601 (266)
Elevated Plasma Levels of Ketone Bodies Are Associated With All‐Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the
Sebastian Niezen +8 more
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Fasting Plasma Ketone Bodies Are Associated with NT-proBNP: A Potential Mechanism to Provide Fuel for the Failing Heart. [PDF]
J Clin MedBackground: Heart failure (HF) features a shift in metabolism towards enhanced utilization of ketone bodies. While elevations in plasma natriuretic peptides represent a biochemical hallmark of HF, natriuretic peptides may promote lipolysis, thereby ...
Palm CL +5 more
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THE DISTRIBUTION OF KETONE BODIES IN TISSUES
Journal of Biological Chemistry, 1940 Helen C. Harrison, C. N. H. Long
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Beta-Hydroxybutyrate: A Dual Function Molecular and Immunological Barrier Function Regulator
Frontiers in Immunology, 2022 Ketone bodies are crucial intermediate metabolites widely associated with treating metabolic diseases. Accumulating evidence suggests that ketone bodies may act as immunoregulators in humans and animals to attenuate pathological inflammation through ...
Jiancheng Qi +11 more
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Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
Nature Metabolism, 2022 During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity ...
Bryon Silva +6 more
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Metabolic and Signaling Roles of Ketone Bodies in Health and Disease.
Annual review of nutrition, 2021 Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and
Patrycja Puchalska, P. Crawford
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Ketone bodies in epilepsy [PDF]
Journal of Neurochemistry, 2012 J. Neurochem.(2012)121, 28–35.AbstractSeizures that are resistant to standard medications remain a major clinical problem. One underutilized option for patients with medication‐resistant seizures is the high‐fat, low‐carbohydrate ketogenic diet. The diet received its name based on the observation that patients consuming this diet produce ketone bodies (
Melanie A. McNally, Adam L. Hartman
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International Journal of Molecular Sciences, 2022 For many years, it has been clear that a Western diet rich in saturated fats and sugars promotes an inflammatory environment predisposing a person to chronic cardiometabolic diseases.
N. Bendridi +3 more
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Ketone bodies as signaling metabolites [PDF]
Trends in Endocrinology & Metabolism, 2014 Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link
Eric Verdin, John C. Newman
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Ketone body oxidation increases cardiac endothelial cell proliferation
EMBO Molecular Medicine, 2022 Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essential substrates for ATP and biomass production; however, the metabolism of other substrates remains poorly understood.
Eva‐Maria Weis +13 more
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