Results 191 to 200 of about 66,773 (266)

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +1 more source

Divergent Access to Fluorinated Pharmacons From Ethyl Trifluoropyruvate. [PDF]

Adv Synth Catal
Nabi RN, Kashatus RC, Joseph KM, Zhang S, Kim DK.   +4 more
europepmc   +1 more source

Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes

Angewandte Chemie, EarlyView.
A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai   +7 more
wiley   +1 more source

Neuronal metabolism role in ketogenic diet improvements in bortezomib-induced painful peripheral neuropathy mouse model. [PDF]

Pain Rep
Heslop LL, Madden TK, Totta-Griese G, Crowards SJ, Hauser W, Ryals J, Baumbauer KM, Wilkins HM, Wright DE.   +8 more
europepmc   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +1 more source

Sustainable Pd‐Catalyzed Aminations “on Dirty Water”

Angewandte Chemie, EarlyView.
Aminations, done safely yet neat, and therefore, quickly, using low levels of Pd, in “dirty water” that must contain 30% KOH; not NaOH, and not at 5%,10%, 20%, 40%, or 50% KOH. Moreover, no base sensitivity of functional groups! Very cool. Thank you, Nature.
Erfan Oftadeh, Marco Ortiz, Kylee Dismuke Rodriguez, Jonathan Yang, Bruce H. Lipshutz   +4 more
wiley   +1 more source

The Progress in NHC-Catalyzed Synthesis of Organosilicon Derivatives. [PDF]

Molecules
Yang X, Yang L, Zhang L, Liang H, Jiang S, Sun J, Hu M.   +6 more
europepmc   +1 more source

Stereospecific Transition-Metal-Free Alkylation of Chiral Non-Racemic Secondary Tosylates with Cyanohydrins: Convenient Access to Enantiomerically Enriched α-Tertiary Ketones. [PDF]

Angew Chem Int Ed Engl
Ma J, Li H, Majhi J, Evans PA.
europepmc   +1 more source

Frontiers in manganese catalysis: a sustainable platform for bond construction and heterocycle synthesis. [PDF]

RSC Adv
Das AK, Sarkar K, Bhattacharjee S, Gajurel S, Dhibar S, Panja SK, Deshmukh SA, Sarkar S.   +7 more
europepmc   +1 more source

Continuous-flow carbonyl hydrogenation under subatmospheric to atmospheric hydrogen pressure enabled by robust heterogeneous Pt-Fe catalysts. [PDF]

Beilstein J Org Chem
Miyamura H, Kajiyama R, Onozawa SY, Kon Y, Kobayashi S.   +4 more
europepmc   +1 more source