Results 41 to 50 of about 179,194 (265)

Ranking of critical species to preserve the functionality of mutualistic networks using the k-core decomposition [PDF]

PeerJ, 2017
Background Network analysis has become a relevant approach to analyze cascading species extinctions resulting from perturbations on mutualistic interactions as a result of environmental change. In this context, it is essential to be able to point out key
Javier García-Algarra, Juan Manuel Pastor, José María Iriondo, Javier Galeano   +3 more
doaj   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Loki: Low-rank Keys for Efficient Sparse Attention

Advances in Neural Information Processing Systems 37
Proceedings of the Thirty-Eighth Annual Conference on Neural Information Processing Systems (Main Conference Track)
Singhania, Prajwal, Singh, Siddharth, He, Shwai, Feizi, Soheil, Bhatele, Abhinav   +4 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Key-Locked Rank One Editing for Text-to-Image Personalization

Special Interest Group on Computer Graphics and Interactive Techniques Conference Conference Proceedings, 2023
Text-to-image models (T2I) offer a new level of flexibility by allowing users to guide the creative process through natural language. However, personalizing these models to align with user-provided visual concepts remains a challenging problem. The task of T2I personalization poses multiple hard challenges, such as maintaining high visual fidelity ...
Yoad Tewel, Rinon Gal, Gal Chechik, Yuval Atzmon   +3 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Applying machine learning to input–output analysis: a new perspective on identifying key Australian industries

Journal of Economic Structures
This article employs two alternative approaches based on input–output tables to re-evaluate key Australian industries and their interconnections. The first approach utilizes traditional linkages, while the second approach employs machine learning methods.
Ali Faridzad
doaj   +1 more source

Framing the university ranking game: actors, motivations, and actions

Ethics in Science and Environmental Politics, 2014
Any formulation of the university ranking game involves the perspectives of the 3 key actors: (1) graduating high-school students, (2) universities, and (3) ranking publications.
JA Dearden, R Grewal, GL Lilien
doaj   +1 more source