Results 61 to 70 of about 1,025,886 (293)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

CoRide: Joint Order Dispatching and Fleet Management for Multi-Scale Ride-Hailing Platforms [PDF]

, 2019
How to optimally dispatch orders to vehicles and how to tradeoff between immediate and future returns are fundamental questions for a typical ride-hailing platform.
Guo, Zilong, Jiao, Yan, Jin, Jiarui, Li, Minne, Qin, Zhiwei, Tang, Xiaocheng, Wang, Chenxi, Wang, Jun, Wu, Guobin, Ye, Jieping, Zhang, Weinan, Zhou, Ming   +11 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Applying machine learning to input–output analysis: a new perspective on identifying key Australian industries

Journal of Economic Structures
This article employs two alternative approaches based on input–output tables to re-evaluate key Australian industries and their interconnections. The first approach utilizes traditional linkages, while the second approach employs machine learning methods.
Ali Faridzad
doaj   +1 more source

Framing the university ranking game: actors, motivations, and actions

Ethics in Science and Environmental Politics, 2014
Any formulation of the university ranking game involves the perspectives of the 3 key actors: (1) graduating high-school students, (2) universities, and (3) ranking publications.
JA Dearden, R Grewal, GL Lilien
doaj   +1 more source

Rank Theorems for Forward Secrecy in Group Key Management Protocols [PDF]

21st International Conference on Advanced Information Networking and Applications Workshops (AINAW'07), 2007
Design and verification of cryptographic protocols has been under investigation for quite sometime. However, little has been done for the class of protocols that deals with group key management and distribution, and have special security properties, such as forward secrecy. In this paper, we define a formal model and establish rank theorems for forward
Amjad Gawanmeh, Sofiene Tahar
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Could the ease of doing business be considered a predictor of countries' socio-economic wealth? An empirical analysis using pls-sem [PDF]

, 2019
The wealth of nations differs significantly due to different factors. One of the reasons identified by previous studies is the level of entrepreneurship promotion by governments. This aspect has scarcely been studied empirically to date.
Leal Rodríguez, Antonio Luis, Sanchís Pedregosa, Carlos   +1 more
core