Results 71 to 80 of about 1,262,593 (332)
Breast, 2020 Objectives: The proliferative activity of the Ki-67 index is important in decision-making of adjuvant treatments in early breast cancer. Its reliability can be reduced by inter-observer variability.
Angela Fischer Maranta +6 more
doaj +1 more source
Five-Year Risk of Cervical Precancer Following p16/Ki-67 Dual-Stain Triage of HPV-Positive Women
JAMA Oncology, 2019 Importance As cervical cancer screening transitions to primary human papillomavirus (HPV) testing, effective triage and management of HPV-positive women is critical to avoid unnecessary colposcopy referral and associated harms while maintaining high ...
M. Clarke +8 more
semanticscholar +1 more source
Diagnostic Pathology, 2020 Background The scoring of Ki-67 is highly relevant for the diagnosis, classification, prognosis, and treatment in breast invasive ductal carcinoma (IDC).
Min Feng +12 more
semanticscholar +1 more source
MKI67 (marker of proliferation Ki-67) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015 Review on MKI67 (marker of proliferation Ki-67), with data on DNA, on the protein encoded, and where the gene is implicated.
Ntzeros, K +7 more
openaire +2 more sources
The role of the two splice variants and extranuclear pathway on Ki-67 regulation in non-cancer and cancer cells [PDF]
, 2017 Ki-67 is a nuclear protein that has been used in cancer diagnostic because of its specific cell-cycle dependent expression profile. After quantifying and characterising the expression level of Ki-67, as a function of the cell cycle, we found out that the
Battaglia, G +5 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Ki-67 as a prognostic marker according to breast cancer molecular subtype
Cancer Biology & Medicine, 2016 Objective: Ki-67 plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published.
Nahed A. Soliman, Shaimaa M. Yussif
doaj +1 more source
Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly
Nature, 2020 Gene expression in eukaryotes requires the effective separation of nuclear transcription and RNA processing from cytosolic translation 1 . This separation is achieved by the nuclear envelope, which controls the exchange of macromolecules through nuclear ...
Sara Cuylen-Haering +7 more
semanticscholar +1 more source
Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma [PDF]
, 2017 Statement of the Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions.
Andisheh-Tadbir, Azadeh. +4 more
core +1 more source