Results 1 to 10 of about 202,716 (285)

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group [PDF]

JNCI: Journal of the National Cancer Institute, 2020
Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to questionable analytical validity.
T. Nielsen, S. Leung, D. Rimm, A. Dodson, B. Ács, S. Badve, C. Denkert, M. Ellis, S. Fineberg, M. Flowers, H. Kreipe, A. Laenkholm, H. Pan, F. Penault-Llorca, M. Polley, R. Salgado, I. Smith, T. Sugie, J. Bartlett, L. McShane, M. Dowsett, D. Hayes   +21 more
semanticscholar   +7 more sources

Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group. [PDF]

JNCI Journal of the National Cancer Institute, 2011
Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells staining for the nuclear antigen Ki67 has become the most widely used method for comparing proliferation between tumor samples.
M. Dowsett, T. Nielsen, R. A’Hern, J. Bartlett, R. C. Coombes, J. Cuzick, M. Ellis, N. L. Henry, J. Hugh, T. Lively, L. McShane, S. Paik, F. Penault-Llorca, Ljudmila Prudkin, M. Regan, J. Salter, C. Sotiriou, I. Smith, G. Viale, J. Zujewski, D. Hayes   +20 more
semanticscholar   +3 more sources

Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future

Endocrine pathology, 2023
The introduction of Ki67 immunohistochemistry in the work-up of neuroendocrine neoplasms (NENs) has opened a new approach for their diagnosis and prognostic evaluation.
S. La Rosa
semanticscholar   +1 more source

Expression, assessment and significance of Ki67 expression in breast cancer: an update

Journal of Clinical Pathology, 2023
Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67 labelling index has prognostic and predictive value in patients with early-stage BC, particularly in
Ayat G. Lashen, M. Toss, Suzan F Ghannam, S. Makhlouf, A. Green, N. Mongan, E. Rakha   +6 more
semanticscholar   +1 more source

Association between Ki67 expression and therapeutic outcome in colon cancer

Oncology Letters, 2023
Ki67 is a commonly used proliferation marker in pathological diagnosis of tumors; however, its prognostic value in colon cancer is controversial. A total of 312 consecutive patients with stage I–III colon cancer who underwent radical surgery with or ...
Qi Liu, D. Ran, Liping Wang, Jiajun Feng, W. Deng, Dongdong Mei, Yi-fan Peng, Changzheng Du   +7 more
semanticscholar   +1 more source

Mesenchymal circulating tumor cells and Ki67: their mutual correlation and prognostic implications in hepatocellular carcinoma

BMC Cancer, 2023
Background Mesenchymal circulating tumor cells (M-CTCs) may be related to tumor progression, and Ki67 expression is known to be involved in tumor proliferation.
Xihua Yang, Hanghang Ni, Zhan Lu, J Zhang, Q. Zhang, S. Ning, Lu-Nan Qi, Bangde Xiang   +7 more
semanticscholar   +1 more source

The Role of Ki67 in Evaluating Neoadjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer

Frontiers in Endocrinology, 2021
Ki67 is a proliferation marker. It has been proposed as a useful clinical marker for breast cancer subtype classification, prognosis, and prediction of therapeutic response.
Ailin Zhang, Xiaojing Wang, Chuifeng Fan, Xiaoyun Mao   +3 more
semanticscholar   +1 more source

Clinical validity and clinical utility of Ki67 in early breast cancer

Therapeutic Advances in Medical Oncology, 2022
Ki67 represents an immunohistochemical nuclear localized marker that is widely used in surgical pathology. Nuclear immunoreactivity for Ki67 indicates that cells are cycling and are in G1- to S-phase.
H. Kreipe, N. Harbeck, M. Christgen
semanticscholar   +1 more source

An International Ki67 Reproducibility Study [PDF]

JNCI: Journal of the National Cancer Institute, 2013
In breast cancer, immunohistochemical assessment of proliferation using the marker Ki67 has potential use in both research and clinical management. However, lack of consistency across laboratories has limited Ki67's value. A working group was assembled to devise a strategy to harmonize Ki67 analysis and increase scoring concordance.
M. C. Polley, S. C. Y. Leung, L. M. McShane, D. Gao, J. C. Hugh, M. G. Mastropasqua, G. Viale, L. A. Zabaglo, F. Penault Llorca, J. M. S. Bartlett, A. M. Gown, W. F. Symmans, T. Piper, E. Mehl, R. A. Enos, D. F. Hayes, M. Dowsett, T. O. Nielsen   +17 more
openaire   +4 more sources

Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]

, 2020
Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal, Ayhan, Chiarelli, Di Palma, Fukunaga, Giampaolino, Heatley, Horita, Houghton, Jiang, Kuwashima, Lin, Longacre, Lu, Ma, Mazur, McAlpine, McCluggage, McCluggage, Moher, Nei, Nomura, Nomura, Němejcová, Ohishi, Ota, Raffone, Raffone, Raffone, Raffone, Raffone, Raffone, Ramos, Stelloo, Strickland, Takahashi, Talhouk, Terada, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Young, Zhang   +46 more
core   +1 more source