A study on molecular subtype of breast carcinoma using ER, HER2, PR, and its relation with Ki67 [PDF]
Journal of Clinical and Basic Research, 2023 Background: Using molecular biomarkers of breast cancer (BC) receives optimal treatment. Established biomarkers like estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67 may play significant roles in the sub-categorization of BC to predict ...
Haricharan BV +7 more
doaj
Comparing computer-generated and pathologist-generated tumour segmentations for immunohistochemical scoring of breast tissue microarrays [PDF]
, 2015 BACKGROUND: Tissue microarrays (TMAs) have become a valuable resource for biomarker expression in translational research. Immunohistochemical (IHC) assessment of TMAs is the principal method for analysing large numbers of patient samples, but manual IHC ...
A Madabhushi +20 more
core +3 more sources
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Polyploid superficial cells that maintain the urothelial barrier are produced via incomplete cytokinesis and endoreplication [PDF]
, 2018 Summary: The urothelium is an epithelia barrier lined by a luminal layer of binucleated, octoploid, superficial cells. Superficial cells are critical for production and transport of uroplakins, a family of proteins that assemble into a waterproof ...
Batourina, Ekatherina +13 more
core +3 more sources
Breast Cancer Research and Treatment, 2020 Purpose The proliferation-associated biomarker Ki67 has potential utility in breast cancer, including aiding decisions based on prognosis, but has unacceptable inter- and intralaboratory variability.
S. Robertson +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
The effect of Aerobic-Resistance Training on the Expression of miR-222 and cTnT, Cx43, Ki67 Genes, and Cardiomyocyte Proliferation in Pre-Pubertal, Young, and Old Male Rats [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: The evidence indicates that exercise training can affect the heart's structure at the cellular-molecular levels. Therefore, this study aimed to investigate the effect of exercise training on miR-222 and the expression of cTnT ...
Bahman Mirzaei +3 more
doaj
Cancer Management and Research, 2021 Peng Jiang, Rui Yuan Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Rui YuanDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical ...
Jiang P, Yuan R
doaj
Developing the Quantitative Histopathology Image Ontology : A case study using the hot spot detection problem [PDF]
, 2017 Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data.
Doyle, Scott +6 more
core
The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems [PDF]
, 2018 In the epidermis, remodelling of Connexin43 is a key event in wound closure. However, controversy between the role of connexin channel and non-channel functions exist.
Annette Graham +7 more
core +4 more sources