Results 11 to 20 of about 203,911 (336)

Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group. [PDF]

JNCI Journal of the National Cancer Institute, 2011
Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells staining for the nuclear antigen Ki67 has become the most widely used method for comparing proliferation between tumor samples.
M. Dowsett, T. Nielsen, R. A’Hern, J. Bartlett, R. C. Coombes, J. Cuzick, M. Ellis, N. L. Henry, J. Hugh, T. Lively, L. McShane, S. Paik, F. Penault-Llorca, Ljudmila Prudkin, M. Regan, J. Salter, C. Sotiriou, I. Smith, G. Viale, J. Zujewski, D. Hayes   +20 more
semanticscholar   +3 more sources

Clinical validity and clinical utility of Ki67 in early breast cancer

Therapeutic Advances in Medical Oncology, 2022
Ki67 represents an immunohistochemical nuclear localized marker that is widely used in surgical pathology. Nuclear immunoreactivity for Ki67 indicates that cells are cycling and are in G1- to S-phase.
H. Kreipe, N. Harbeck, M. Christgen
semanticscholar   +1 more source

ОСОБЕННОСТИ ЛОКАЛЬНОГО ИММУННОГО ОТВЕТА И ИММУНОГИСТОХИМИЧЕСКИЕ МАРКЕРЫ ПРОГНОЗА ПРИ РАКЕ ШЕЙКИ МАТКИ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2023
Согласно современным данным, рак шейки матки (РШМ) занимает одно из ведущих мест в структуре злокачественных новообразований у женщин Республики Беларусь и Российской Федерации, а также является четвертым по распространенности видом рака среди женщин во ...
О. В. Шиман, В. С. Алексинский   +1 more
doaj   +1 more source

Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

Modern Pathology, 2022
Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the ...
B. Ács, S. Leung, K. Kidwell, I. Arun, R. Augulis, S. Badve, Yalai Bai, A. Bane, J. Bartlett, J. Bayani, G. Bigras, A. Blank, H. Buikema, Martin C. Chang, R. Dietz, A. Dodson, S. Fineberg, C. Focke, D. Gao, A. Gown, C. Gutierrez, J. Hartman, Z. Kos, A. Lænkholm, A. Laurinavičius, R. Levenson, R. Mahboubi-Ardakani, M. Mastropasqua, S. Nofech-Mozes, C. Osborne, F. Penault-Llorca, T. Piper, M. Quintayo, T. Rau, Stefan Reinhard, S. Robertson, R. Salgado, T. Sugie, B. van der Vegt, G. Viale, L. Zabaglo, D. Hayes, M. Dowsett, T. Nielsen, D. Rimm, Mitch Daniel F. Lisa M. Kelley M. Torsten Samuel Balazs Dowsett Hayes McShane Kidwell Nielsen Leung Acs Ar, M. Dowsett, D. Hayes, L. McShane, T. Nielsen, S. Leung, B. Ács, R. Augulis, S. Badve, Yalai Bai, A. Bane, G. Bigras, A. Blank, S. Borgquist, H. Buikema, A. Chan, C. Denkert, R. Dietz, A. Dodson, A. Ehinger, M. Ellis, M. Flowers, C. Galderisi, Abhi Gholap, A. Gown, C. Gutierrez, D. Hartman, J. Hartman, J. Hugh, Anagha P. Jadhav, E. Kornaga, Z. Kos, H. Kreipe, A. Lænkholm, A. Laurinavičius, R. Levenson, M. Mastropasqua, Takuya Moriya, C. Osborne, H. Pan, L. Pantanowitz, Ernesta Paola Neri, F. Penault-Llorca, M. Polley, T. Piper, M. Quintayo, T. Rau, D. Rimm, Stefan Reinhard, S. Robertson, J. Ruan, T. Sakatani, R. Salgado, L. Shepherd, I. Smith, J. Sparano, M. Spears, M. Srinivasan, J. Starczynski, A. Todd, B. van der Vegt, G. Viale, S. Virk, Yihong Wang, Huanming Yang, Zhiwei Zhang, I. Zlobec   +111 more
semanticscholar   +1 more source

An International Ki67 Reproducibility Study [PDF]

JNCI: Journal of the National Cancer Institute, 2013
In breast cancer, immunohistochemical assessment of proliferation using the marker Ki67 has potential use in both research and clinical management. However, lack of consistency across laboratories has limited Ki67's value. A working group was assembled to devise a strategy to harmonize Ki67 analysis and increase scoring concordance.
M. C. Polley, S. C. Y. Leung, L. M. McShane, D. Gao, J. C. Hugh, M. G. Mastropasqua, G. Viale, L. A. Zabaglo, F. Penault Llorca, J. M. S. Bartlett, A. M. Gown, W. F. Symmans, T. Piper, E. Mehl, R. A. Enos, D. F. Hayes, M. Dowsett, T. O. Nielsen   +17 more
openaire   +4 more sources

Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]

, 2020
Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal, Ayhan, Chiarelli, Di Palma, Fukunaga, Giampaolino, Heatley, Horita, Houghton, Jiang, Kuwashima, Lin, Longacre, Lu, Ma, Mazur, McAlpine, McCluggage, McCluggage, Moher, Nei, Nomura, Nomura, Němejcová, Ohishi, Ota, Raffone, Raffone, Raffone, Raffone, Raffone, Raffone, Ramos, Stelloo, Strickland, Takahashi, Talhouk, Terada, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Young, Zhang   +46 more
core   +1 more source

Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity

International Journal of Molecular Sciences, 2021
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0 state of quiescence or, alternatively, they may undergo an irreversible G0 state.
N. Alessio, Domenico Aprile, S. Cappabianca, G. Peluso, G. Di Bernardo, U. Galderisi   +5 more
semanticscholar   +1 more source

Dynamic monitoring of PD‐L1 and Ki67 in circulating tumor cells of metastatic non‐small cell lung cancer patients treated with pembrolizumab

Molecular Oncology, 2022
Programmed cell death protein ligand‐1 (PD‐L1) expression in non‐small cell lung cancer (NSCLC) tumors guides treatment selection. PD‐L1 expression in circulating tumor cells (CTCs) may provide further information.
M. Spiliotaki, C. Neophytou, P. Vogazianos, I. Stylianou, G. Gregoriou, A. Constantinou, C. Deltas, H. Charalambous   +7 more
semanticscholar   +1 more source

Inflammatory myofibroblastic tumor manifesting as recurrent generalized gingival enlargement: Report of a rare case

Indian Journal of Pathology and Microbiology, 2020
Oral inflammatory myofibroblastic tumor (IMT) is extremely rare and its manifestation as generalized gingival enlargement (GGE) has never been reported.
Vikender S Yadav, Prasenjit Das, Renu Yadav, Nitesh Tewari   +3 more
doaj   +1 more source

Recurrence and mortality rate in an Italian multi-center case series of parathyroid atypical adenomas and carcinomas

Frontiers in Endocrinology, 2023
IntroductionThere are few data regarding the clinical outcome of patients with parathyroid carcinoma (PC) and atypical adenoma (AA) after surgery. Aim of our study was to investigate disease recurrence and mortality rate as well as their predictors in a ...
Marco Barale, Alice Nervo, Andrea Craparo, Alessia Pusterla, Francesca Retta, Federica Maiorino, Elena Castellano, Alessandro Piovesan, Laura Gianotti, Giorgio Borretta, Massimo Procopio, Emanuela Arvat   +11 more
doaj   +1 more source