Results 11 to 20 of about 202,716 (285)

Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

Modern Pathology, 2022
Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the ...
B. Ács, S. Leung, K. Kidwell, I. Arun, R. Augulis, S. Badve, Yalai Bai, A. Bane, J. Bartlett, J. Bayani, G. Bigras, A. Blank, H. Buikema, Martin C. Chang, R. Dietz, A. Dodson, S. Fineberg, C. Focke, D. Gao, A. Gown, C. Gutierrez, J. Hartman, Z. Kos, A. Lænkholm, A. Laurinavičius, R. Levenson, R. Mahboubi-Ardakani, M. Mastropasqua, S. Nofech-Mozes, C. Osborne, F. Penault-Llorca, T. Piper, M. Quintayo, T. Rau, Stefan Reinhard, S. Robertson, R. Salgado, T. Sugie, B. van der Vegt, G. Viale, L. Zabaglo, D. Hayes, M. Dowsett, T. Nielsen, D. Rimm, Mitch Daniel F. Lisa M. Kelley M. Torsten Samuel Balazs Dowsett Hayes McShane Kidwell Nielsen Leung Acs Ar, M. Dowsett, D. Hayes, L. McShane, T. Nielsen, S. Leung, B. Ács, R. Augulis, S. Badve, Yalai Bai, A. Bane, G. Bigras, A. Blank, S. Borgquist, H. Buikema, A. Chan, C. Denkert, R. Dietz, A. Dodson, A. Ehinger, M. Ellis, M. Flowers, C. Galderisi, Abhi Gholap, A. Gown, C. Gutierrez, D. Hartman, J. Hartman, J. Hugh, Anagha P. Jadhav, E. Kornaga, Z. Kos, H. Kreipe, A. Lænkholm, A. Laurinavičius, R. Levenson, M. Mastropasqua, Takuya Moriya, C. Osborne, H. Pan, L. Pantanowitz, E. P. Neri, F. Penault-Llorca, M. Polley, T. Piper, M. Quintayo, T. Rau, D. Rimm, Stefan Reinhard, S. Robertson, J. Ruan, T. Sakatani, R. Salgado, L. Shepherd, I. Smith, J. Sparano, M. Spears, M. Srinivasan, J. Starczynski, A. Todd, B. van der Vegt, G. Viale, S. Virk, Yihong Wang, Huanming Yang, Zhiwei Zhang, I. Zlobec   +111 more
semanticscholar   +1 more source

Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity

International Journal of Molecular Sciences, 2021
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0 state of quiescence or, alternatively, they may undergo an irreversible G0 state.
N. Alessio, D. Aprile, S. Cappabianca, G. Peluso, G. Di Bernardo, U. Galderisi   +5 more
semanticscholar   +1 more source

Dynamic monitoring of PD‐L1 and Ki67 in circulating tumor cells of metastatic non‐small cell lung cancer patients treated with pembrolizumab

Molecular Oncology, 2022
Programmed cell death protein ligand‐1 (PD‐L1) expression in non‐small cell lung cancer (NSCLC) tumors guides treatment selection. PD‐L1 expression in circulating tumor cells (CTCs) may provide further information.
M. Spiliotaki, C. Neophytou, P. Vogazianos, I. Stylianou, G. Gregoriou, A. Constantinou, C. Deltas, H. Charalambous   +7 more
semanticscholar   +1 more source

Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods

Histopathology, 2022
Ki67 reflects the proliferation activity in breast cancer (BC). However, an optimal method for its assessment in clinical settings has yet to be robustly defined.
Ayat G. Lashen, M. Toss, A. Green, N. Mongan, E. Rakha   +4 more
semanticscholar   +1 more source

Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Barlow, A Pini Prato, A Zani, AG Baynash, AG Catto-Smith, AJ Burns, AJ Burns, Alan J. Burns, AS Wallace, C Caldwell, C Kalcheim, C Laranjeira, CH Knowles, Conor McCann, D Natarajan, Dipa Natarajan, DM Rodrigues, E Panza, Ellen Binder, GE Boeckxstaens, H Tsuji, HM Pallari, J Amiel, Jean-Marie Delalande, Julie Cooper, L Becker, L Ludman, M Hanani, M Metzger, Mara Cananzi, MC Nunes, MD Gershon, Mirella Dottori, MP Sanchez, MT Liu, N Bondurand, N Nagoshi, N Thapar, Nikhil Thapar, NR Druckenbrod, PS Danielian, R Hotta, R Hotta, R Zufferey, Rania Kronfli, RC Mifflin, RM Lindley, S Almond, S Bixby, S Hetz, S Srinivas, S Theocharatos, SJ Conway, SJ Howe, SJ McKeown, TA Heanue, TP Rothman, U Rauch, V Sasselli, X Jiang, Y Matsuda, YH Tsai   +61 more
core   +17 more sources

Noninvasive Method for Predicting the Expression of Ki67 and Prognosis in Non-Small-Cell Lung Cancer Patients: Radiomics

Journal of Healthcare Engineering, 2022
Purpose In this study, we aimed to develop and validate a noninvasive method based on radiomics to evaluate the expression of Ki67 and prognosis of patients with non-small-cell lung cancer (NSCLC). Patients and Methods. A total of 120 patients with NSCLC
W. Yao, Yifeng Liao, Xiapeng Li, Feng Zhang, Haifeng Zhang, Baoli Hu, Xiaolong Wang, Li Li, Mei Xiao   +8 more
semanticscholar   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis

Oncology Letters, 2022
Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly ...
Ji Li, Anzhe Wang, Xiao-dong Chen, H. Pan, Shi-Qiang Li   +4 more
semanticscholar   +1 more source

Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial

The Lancet Oncology, 2020
Summary Background Preoperative and perioperative aromatase inhibitor (POAI) therapy has the potential to improve outcomes in women with operable oestrogen receptor-positive primary breast cancer.
I. Smith, J. Robertson, L. Kilburn, M. Wilcox, A. Evans, C. Holcombe, K. Horgan, C. Kirwan, E. Mallon, M. Sibbering, A. Skene, R. Vidya, M. Cheang, J. Banerji, J. Morden, Kally Sidhu, A. Dodson, J. Bliss, M. Dowsett   +18 more
semanticscholar   +1 more source

Effects of neoadjuvant trastuzumab, pertuzumab and palbociclib on Ki67 in HER2 and ER-positive breast cancer

npj Breast Cancer, 2022
The crosstalk between estrogen and HER2 receptors and cell-cycle regulation sustains resistance to endocrine therapy of HER2- and hormone receptor-positive breast cancer.
L. Gianni, M. Colleoni, G. Bisagni, M. Mansutti, C. Zamagni, L. Del Mastro, S. Zambelli, G. Bianchini, A. Frassoldati, I. Maffeis, P. Valagussa, G. Viale   +11 more
semanticscholar   +1 more source