Results 51 to 60 of about 203,911 (336)

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

Targeting PKCθ promotes satellite cell self-renewal [PDF]

, 2020
Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In this study we examined
Benedetti, Anna, Bouché, Marina, Fiore, Piera Filomena, Lozanoska-Ochser, Biliana, Madaro, Luca   +4 more
core   +1 more source

Magnetic resonance imaging-based radiomics signature for preoperative prediction of Ki67 expression in bladder cancer

Cancer Imaging, 2021
Purpose The Ki67 expression is associated with the advanced clinicopathological features and poor prognosis in bladder cancer (BCa). We aimed to develop and validate magnetic resonance imaging (MRI)-based radiomics signatures to preoperatively predict ...
Zongtai Zheng, Zhuoran Gu, Feijia Xu, Niraj Maskey, Yanyan He, Yang Yan, Tianyuan Xu, Shenghua Liu, X. Yao   +8 more
semanticscholar   +1 more source

Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling

South Asian Journal of Cancer, 2018
Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, and key risk factors. The use of gene expression assays for early stage disease is already common practice.
S Aggarwal, A Vaid, A Ramesh, Purvish M Parikh, S Purohit, B Avasthi, S Gupta, S Ranjan, V Kaushal, S Salim, R Singh, S Minhas, D Doval   +12 more
doaj   +1 more source

STAT3 Expression and Correlation Between Ki-67 and PHH3 in Meningiomas: Is it Possible to Predict Recurrence?

Düzce Tıp Fakültesi Dergisi, 2022
Aim: The aim of this study was to investigate the correlation between PHH3 and ki-67 labeling index, and the association of STAT3 expression with mitotic index, grade by World Health Organization 2016 classification, and clinicopathological features of ...
Sinem Kantarcıoğlu Coşkun, Güven Kılıç   +1 more
doaj   +1 more source

p16/ki67 and E6/E7 mRNA accuracy and prognostic value in triaging HPV DNA-positive women.

Journal of the National Cancer Institute, 2020
BACKGROUND The study presents cross-sectional accuracy of E6/E7 mRNA detection and p16/ki67 dual staining, alone or in combination with cytology and HPV16/18 genotyping, as triage test in HPV DNA-positive women and their impact on CIN2+ overdiagnosis ...
P. Giorgi Rossi, F. Carozzi, G. Ronco, E. Allia, S. Bisanzi, Anna Gillio-Tos, L. Marco, Raffaella Rizzolo, D. Gustinucci, A. Del Mistro, H. Frayle, M. Confortini, A. Iossa, E. Cesarini, S. Bulletti, B. Passamonti, S. Gori, Laura Toniolo, A. Barca, Laura Bonvicini, P. Mancuso, F. Venturelli, M. Benevolo   +22 more
semanticscholar   +1 more source

Correlation Analysis of Ki67 Expression and EGFR Mutation on the Risk of Recurrence and Metastasis in Postoperative Patients with Stage I Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2022
Background and objective The prognosis of stage I non-small cell lung cancer (NSCLC) is generally good. However, some of the stage I NSCLC patients still may have early recurrence and metastasis, and there is no standard method to screen this part of the
Lili XU, Renhua GUO
doaj   +1 more source

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger, Enghard, Philipp, Humrich, Jens, Kloke, Lutz, Kühl, Anja, Riemekasten, Gabriela, Rose, Angelika, von Spee-Mayer, Caroline, Wu, Kaiyin   +8 more
core   +2 more sources

Predicting recurrence of non-muscle invasive bladder urothelial carcinoma: predictive value of the optimal cut-off value of Ki67

Frontiers in Oncology
ObjectiveTo investigate the optimal cut-off value of immunohistochemical marker Ki67 as a prognostic factor to predict the recurrence of non-muscle invasive bladder urothelial carcinoma (NMIBUC).MethodsA total of 331 patients diagnosed with NMIBUC who ...
Rende Peng, Yaoyu Zhang, Mingzhu Jia, Xinping Yi, Xiaoyao Yi, Shadan Li, Jiangchuan Pi, Wenjun Meng   +7 more
doaj   +1 more source

RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells

Endocrine Connections, 2021
A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study was to correlate the full RET and RAS mutation profile,
Cristina Romei, Teresa Ramone, Chiara Mulè, Alessandro Prete, Virginia Cappagli, Loredana Lorusso, Liborio Torregrossa, Fulvio Basolo, Raffaele Ciampi, Rossella Elisei   +9 more
doaj   +1 more source