Results 1 to 10 of about 85,860 (310)
Cell Volume Regulation in the Proximal Tubule of Rat Kidney [PDF]
Bulletin of Mathematical Biology, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment. We examined whether regulatory volume decrease (RVD), which follows exposure to a hyposmotic peritubular solution, can be achieved solely via stimulation of basolateral K[Formula: see text] and ...
Aurélie Edwards, Anita T. Layton
openaire +6 more sources
Iron Is Filtered by the Kidney and Is Reabsorbed by the Proximal Tubule [PDF]
Frontiers in Physiology, 2021 The aim of this study was to determine the iron (Fe) concentration profile within the lumen of the S2 renal proximal convoluted tubule (PCT) and to resolve whether this nephron segment transported Fe. To do this, we performed in vivo renal micropuncture on Wistar rats, collected PCT tubular fluid from superficial nephrons, and measured Fe concentration.
Wareing, Mark, Smith, Craig P.
openaire +4 more sources
Nephroprotective Impacts of <i>Hyphaene thebaica</i> (Doum) Against Gentamicin-Induced Renal Toxicity Through Different Signaling Pathways. [PDF]
Food Sci NutrHyphaene thebaica extract ameliorated nephrotoxic effects of gentamycin through its role as anti‐inflammatory mediators by regulating NFkB, COX‐2, and TGF‐β1 expressions. Moreover, H. thebaica regulated the expression of inflammation‐associated apoptotic genes. H.
Althobaiti SA.
europepmc +2 more sources
AQP1 expression in the proximal tubule of diabetic rat kidney [PDF]
Heliyon, 2020 Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown ...
Erika A. Seyahian +3 more
openaire +5 more sources
Visualization of Calcium Dynamics in Kidney Proximal Tubules [PDF]
Journal of the American Society of Nephrology, 2015 Intrarenal changes in cytoplasmic calcium levels have a key role in determining pathologic and pharmacologic responses in major kidney diseases. However, cell-specific delivery of calcium-sensitive probes in vivo remains problematic. We generated a transgenic rat stably expressing the green fluorescent protein-calmodulin-based genetically encoded ...
Szebényi, Kornélia +13 more
openaire +4 more sources
Mechanosensory function of microvilli of the kidney proximal tubule [PDF]
Proceedings of the National Academy of Sciences, 2004 Normal variations in glomerular filtration induce proportional changes in proximal tubule Na + reabsorption. This “glomerulotubular balance” derives from flow dependence of Na + uptake across luminal cell membranes; however, the underlying physical mechanism is unknown. Our hypothesis is that
Tong Wang +5 more
openaire +3 more sources
Conductive properties of the proximal tubule in Necturus kidney. [PDF]
The Journal of general physiology, 1980 The electrical properties of the proximal tubule of the in vivo Necturus kidney were investigated by injecting current (as rectangular waves) into the lumen or into the epithelium of single tubules and by studying the resulting changes of transepithelial (VL) and/or cell membrane potential (VC) at various distances from the source.
A Edelman, T Anagnostopoulos, J. Teulon
openaire +3 more sources
Axial differences in endocytosis along the kidney proximal tubule [PDF]
American Journal of Physiology-Renal Physiology, 2019 The proximal tubule (PT) reabsorbs filtered proteins via receptor-mediated endocytosis to prevent energetically inefficient wasting in the urine. Recent intravital imaging studies have suggested that protein reabsorption occurs in early (S1) segments, which have a very high capacity.
Polesel, Marcello, Hall, Andrew M
openaire +4 more sources
POTASSIUM ACCUMULATION IN THE PROXIMAL CONVOLUTED TUBULES OF THE FROG'S KIDNEY [PDF]
Journal of General Physiology, 1946 1. In a manner similar to that of the sartorius muscle, the isolated kidney of the frog can accumulate K against a gradient to upwards of three times its normal concentration. 2. The K-accumulating region is identified as the proximal tubule, which in the isolated tissue immersed over 24 hours in the cold (2–3°C.) amounts to about 90 per
E. J. Conway +2 more
openaire +4 more sources
The proximal tubule in the pathophysiology of the diabetic kidney
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011 Diabetic nephropathy is a leading cause of end-stage renal disease. A better understanding of the molecular mechanism involved in the early changes of the diabetic kidney may permit the development of new strategies to prevent diabetic nephropathy. This review focuses on the proximal tubule in the early diabetic kidney, particularly on its exposure and
openaire +4 more sources