Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation [PDF]
Scientific ReportsAcute kidney injury (AKI) can progress to chronic kidney disease (CKD), via a mechanism that is still largely unknown. We previously reported that glucosylceramide (GlcCer) acts as a damage-associated molecular pattern (DAMP) during AKI.
Akinori Osada +14 more
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CaOx crystal nuclei are formed in rat outer cortex proximal tubules by a potential fibrinogen-dependent mechanism. [PDF]
PLoS ONECalcium oxalate (CaOx) stones are prevalent in urinary tract stone disease. While their formation can be induced in rats by administering ethylene glycol and vitamin D, the initial nucleation and formation processes are unclear.
Kenshirou Kunii +13 more
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TNF-α induces Claudin-1 expression in renal tubules in Alport mice
PLoS ONE, 2022 Claudin-1 (CL-1) is responsible for the paracellular barrier function of glomerular parietal epithelial cells (PEC) in kidneys, but the role of CL-1 in proximal tubules remains to be elucidated.
Manami Iida +7 more
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mutation: a benign genetic cause of proteinuria? [PDF]
Childhood Kidney Diseases, 2023 Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease.
Hyun Kyung Lee
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Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)
Tikrit Journal of Pure Science, 2023 This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta +4 more
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Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. [PDF]
PLoS ONE, 2012 Bcl-2 and Bax play an important role in apoptosis regulation, as well as in cell adhesion and migration during kidney morphogenesis, which is structurally and functionally related to mitochondria.
Xiao-Feng Song +4 more
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Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule
Toxins, 2022 Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown.
Fumiko Obata +4 more
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Visualization of Calcium Dynamics in Kidney Proximal Tubules [PDF]
Journal of the American Society of Nephrology, 2015 Intrarenal changes in cytoplasmic calcium levels have a key role in determining pathologic and pharmacologic responses in major kidney diseases. However, cell-specific delivery of calcium-sensitive probes in vivo remains problematic. We generated a transgenic rat stably expressing the green fluorescent protein-calmodulin-based genetically encoded ...
Szebényi, Kornélia +13 more
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TIGAR regulates glycolysis in ischemic kidney proximal tubules [PDF]
American Journal of Physiology-Renal Physiology, 2015 Tp53-induced glycolysis and apoptosis regulator (TIGAR) activation blocks glycolytic ATP synthesis by inhibiting phosphofructokinase-1 activity. Our data indicate that TIGAR is selectively induced and activated in renal outermedullary proximal straight tubules (PSTs) after ischemia-reperfusion injury in a p53-dependent manner.
Jinu, Kim +2 more
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Differentiated kidney epithelial cells repair injured proximal tubule [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance When epithelial cells in the proximal portion of the nephron are damaged they rapidly proliferate to repair the damage to the kidney. Whether a stem cell is responsible for this proliferative response or not is controversial.
Tetsuro, Kusaba +4 more
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