Results 11 to 20 of about 85,860 (310)

Expression of Bcl-2 and Bax in Mouse Renal Tubules during Kidney Development [PDF]

PLoS ONE, 2012
Bcl-2 and Bax play an important role in apoptosis regulation, as well as in cell adhesion and migration during kidney morphogenesis, which is structurally and functionally related to mitochondria.
A Andreasen, A Autret, A Torchinsky, AH Wyllie, AM Hall, Arne Andreasen, B Chen, B Westermann, CE Ruegg, CM Sorenson, D Carev, D Patschan, DP Basile, DV Novack, E Erkan, E Kellenberger, E Messaris, F Costantini, Hao Ren, I Arany, J Yang, J Ziehr, Jesper Skovhus Thomsen, JG Foley, KA Walker, LM Fedorov, M Hayashi, M Lamkanfi, MR Hammerman, N Sheibani, P Li, P Marchetti, P Saikumar, PG Clarke, S Uchida, SG Rolland, Shree Ram Singh, SJ Riedl, T Kuwana, V Mikhailov, Xiao-Feng Song, Xiao-Yue Zhai, XY Zhai, XY Zhai, YJ Kim   +44 more
core   +4 more sources

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes. [PDF]

Redox Biol
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as ...
Trambas IA, Bowen L, Thallas-Bonke V, Snelson M, Sourris KC, Laskowski A, Tauc M, Rubera I, Zheng G, Harris DCH, Kantharidis P, Shimizu T, Cooper ME, Tan SM, Coughlan MT.   +14 more
europepmc   +2 more sources

mutation: a benign genetic cause of proteinuria? [PDF]

Childhood Kidney Diseases, 2023
Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease.
Hyun Kyung Lee
doaj   +1 more source

TNF-α induces Claudin-1 expression in renal tubules in Alport mice

PLoS ONE, 2022
Claudin-1 (CL-1) is responsible for the paracellular barrier function of glomerular parietal epithelial cells (PEC) in kidneys, but the role of CL-1 in proximal tubules remains to be elucidated.
Manami Iida, Shuichi Ohtomo, Naoko A. Wada, Otoya Ueda, Yoshinori Tsuboi, Atsuo Kurata, Kou-ichi Jishage, Naoshi Horiba   +7 more
doaj   +2 more sources

Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule

Toxins, 2022
Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown.
Fumiko Obata, Ryo Ozuru, Takahiro Tsuji, Takashi Matsuba, Jun Fujii   +4 more
doaj   +1 more source

Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype

Cells, 2022
Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking impairment, oxidative stress, and apoptosis. Additionally, cystinotic patients
Elena Sendino Garví, Rosalinde Masereeuw, Manoe J. Janssen   +2 more
doaj   +1 more source

Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney [PDF]

Scientific Data 10, 510 (2023), 2021
The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume, high-quality training datasets, which require state-of-the-art imaging facilities, domain experts for annotation and ...
arxiv   +1 more source

The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension

Frontiers in Physiology, 2022
The sodium (Na+)/hydrogen (H+) exchanger 3 (NHE3) is one of the most important Na+/H+ antiporters in the small intestines of the gastrointestinal tract and the proximal tubules of the kidney.
Sarah M. Nwia, Sarah M. Nwia, Xiao Chun Li, Xiao Chun Li, Ana Paula de Oliveira Leite, Ana Paula de Oliveira Leite, Rumana Hassan, Rumana Hassan, Jia Long Zhuo, Jia Long Zhuo   +9 more
doaj   +1 more source

Heat-shock mediated overexpression of HNF1β mutations has differential effects on gene expression in the Xenopus pronephric kidney. [PDF]

, 2012
The transcription factor HNF1B, encoded by the TCF2 gene, plays an important role in the organogenesis of vertebrates. In humans, heterozygous mutations of HNF1B are associated with several diseases, such as pancreatic β-cell dysfunction leading to ...
Brändli, André W., Gull, Mazhar, Kahnert, Stefan, Roose, Magdalena, Ryffel, Gerhart U., Sauert, Kathrin, Waldner, Christoph   +6 more
core   +7 more sources

Fine Structure of the Trunk Kidney and Distribution of Its Secreted Exosomes in the Adult Zebrafish

Shiyan dongwu yu bijiao yixue, 2023
Objective To observe the fine structure of the trunk kidney in zebrafish, and to identify its secreted exosomes.Methods The microstructure and ultrastructure of the trunk kidney in zebrafish were observed by light microscopy and electron microscopy, and ...
LIN Jinxing, WANG Xindong, BAI Xuebing, FENG Liping, XIE Shuwu, CHEN Qiusheng   +5 more
doaj   +1 more source