Results 201 to 210 of about 86,303 (320)

From blood flow to organ function: The physiology of autoregulatory dynamics

Experimental Physiology, EarlyView.
Niels‐Henrik Holstein‐Rathlou, Donald J. Marsh   +1 more
wiley   +1 more source

Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change

BioEssays, Volume 47, Issue 6, June 2025.
Cell shape changes underlie animal development, physiology, and disease. The cell surface is mechanosensitive to the microenvironment and cytoskeleton activities, which generate plasma membrane topographies recognized and affected by Arp2/3 actin network induction pathways to remodel cell shape during immune cell migration, neural progenitor cell ...
Tony J. C. Harris
wiley   +1 more source

The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice

Brain and Behavior, Volume 15, Issue 6, June 2025.
The small molecules RepSox and TCP were investigated for their geroprotective effects in aging C3H mice through intraperitoneal administration. Treatment resulted in improved neurological markers and physical parameters in older mice (16‐20 months), while younger treated mice (10‐13 months) showed increased maximum lifespan compared to controls.
Maria Vedunova, Olga Borysova, Elena Mitroshina, Ivan Morgunov, Alexander Fedintsev, Alexey Moskalev   +5 more
wiley   +1 more source

mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney. [PDF]

Front Immunol
Atwood DJ, He Z, Miyazaki M, Hopp K, Jani A, Furgeson SB, Faubel S, Edelstein CL.   +7 more
europepmc   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, Volume 11, Issue 2, Page 89-104, June 2025.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Intravital imaging of peritubular microcirculation impairment in cisplatin-induced acute kidney injury. [PDF]

JCI Insight
Park I, Kim S, Um YW, Kim HE, Lee JH, Kim S, Kim P, Jo YH.   +7 more
europepmc   +1 more source

Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
ISG15 is highly expressed in both DKD mice and renal tubular epithelial cell cultured in HG condition. ISG15 promotes DKD pyroptosis via NLRP3–CASP1–GSDMD axis. ISG15–mtDNA–STING emerges as a critical hub that integrates the processes of pyroptosis .
Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang   +8 more
wiley   +1 more source

Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice. [PDF]

Sci Rep
Cwiek A, Dailey RK, Kameshwar AKS, Suzuki M, Isaac J, deRonde K, Conaway M, Bennett KM, Baldelomar EJ, Li T, Wu T, Hoch MR, Chavkin NW, Walker PD, Hirschi KK, Reidy KJ, Charlton JR.   +16 more
europepmc   +1 more source

NAD+ prevents chronic kidney disease by activating renal tubular metabolism. [PDF]

JCI Insight
Jones BA, Gisch DL, Myakala K, Sadiq A, Cheng YH, Taranenko E, Panov J, Korolowicz K, Melo Ferreira R, Yang X, Santo BA, Allen KC, Yoshida T, Wang XX, Rosenberg AZ, Jain S, Eadon MT, Levi M.   +17 more
europepmc   +1 more source

Randomized trial to assess worsening renal function by adding dapagliflozin for acute decompensated heart failure

ESC Heart Failure, Volume 12, Issue 3, Page 2023-2033, June 2025.
Abstract Aims Dapagliflozin (DAPA), a sodium‐glucose co‐transporter 2 inhibitor, has been shown to reduce cardiovascular mortality among patients with chronic heart failure. We aimed to evaluate the impact on a worsening renal function (WRF) by adding DAPA as compared to standard decongestive therapy with loop diuretics alone.
Shodai Kawanami, Yasuyuki Egami, Masaru Abe, Mizuki Osuga, Hiroaki Nohara, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga‐Lee, Masamichi Yano, Masami Nishino   +11 more
wiley   +1 more source