Results 201 to 210 of about 73,145 (294)

Alporting Trouble Down the Tubules. [PDF]

Kidney Int Rep
Chan M, Gross O.
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Autoimmune reactions to ACE2 triggered by SARS-CoV-2 S protein and their histopathological consequences. [PDF]

Sci Rep
Beduleva L, Fomina K, Khramova T, Terentiev A, Menshikova D, Terentieva O, Menshikov I, Sidorov A, Makhankova P, Abisheva N.   +9 more
europepmc   +1 more source

Single‐Chain Anti‐IL‐1β Antibody Carried by Outer Membrane Vesicles of Bacteroides fragilis Alleviates Tubular Inflammation in Chronic Kidney Disease

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Engineered Bacteroides fragilis outer membrane vesicles carrying anti‐IL‐1β scFv and kidney‐targeting peptides alleviate renal inflammation and injury in CKD mouse models via precise delivery and NF‐κB inhibition. ABSTRACT Microinflammation is a key driver of chronic kidney disease (CKD) progression, with interleukin‐1β (IL‐1β) playing a pivotal role ...
Liang Li, Xue Qi Li, Jia Xiu Zhang, Qin Yi Wu, Pei Pei Chen, Xiong Zhong Ruan, Kun Ling Ma   +6 more
wiley   +1 more source

Immunolocalization of p53 and p21 in Kidneys Exposed to T-2 Mycotoxin. [PDF]

Curr Issues Mol Biol
Hussar P, Blagoevska K, Dovenska M, Pendovski L, Popovska-Percinic F.   +4 more
europepmc   +1 more source

Development and Validation of a Novel Scoring Model Integrating Clinical Risk Factors and Pharmacokinetic Parameters to Predict Vancomycin‐Induced Nephrotoxicity

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Vancomycin (VCM), a first‐line treatment option for infections caused by methicillin‐resistant Staphylococcus aureus, has been reported to cause nephrotoxicity even within therapeutic concentration ranges. Traditional therapeutic drug monitoring strategies rely primarily on the area under the concentration–time curve (AUC), without ...
Yoshihiko Matsuki, Ken‐ichi Sako, Yutaro Kozima, Tamaki Watanabe, Yasuharu Kashiwagura, Nobuhiro Yasuno, Shigekazu Watanabe   +6 more
wiley   +1 more source

Is Cooler Safer and More Advantageous? A Feasibility Study in Rabbits. [PDF]

Eur J Cardiothorac Surg
Şişli E, Kar F, İnan K, Taştekin T, Şahin A, Çetinkaya D, Burukoğlu Dönmez D, Uslu S, Dernek S.   +8 more
europepmc   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

Aging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell, Cecília G. de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J. E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph V. Bonventre, Vadim N. Gladyshev   +9 more
wiley   +1 more source

Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function. [PDF]

Proc Natl Acad Sci U S A
M Viquez O, Melzer M, Li S, Tantengco M, Dong X, Sha E, Huang J, Krystofiak ES, Hart RC, Luo W, Warren C, Bayazid AB, Zhang R, Bessho R, Haase VH, Brakebusch C, Inoue T, Brooks C, Wilson MH, Terker AS, Arroyo JP, Pozzi A, Zent R, Bock F.   +23 more
europepmc   +1 more source

Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 826-839, February 2026.
Abstract Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder usually caused by the variant m.3243A>G in the MT‐TL1 gene. We have proposed that diabetes in MIDD arises from a combination of insulin resistance and impaired β‐cell function that is more likely to occur in the presence of high skeletal muscle heteroplasmy and ...
Ahsen Chaudhry, David M. Thompson, Jean‐Pierre Chanoine   +2 more
wiley   +1 more source