Results 121 to 130 of about 127,828 (193)

Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury

FASEB BioAdvances, Volume 7, Issue 4, April 2025.
In this study, we used bioinformatics and in vitro and in vivo validations to discover the close association of Fosb with AKI, which was significantly upregulated in AKI. Furthermore, Fosb promoted apoptosis through AP‐1 signaling pathway‐mediated inflammatory responses in renal tubular epithelial cells, suggesting that it has the potential to be a ...
Xiaoyan Tang, Changqiong Shen, Chunqiu Liu, Jianya Gao   +3 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Loach Goby Rhyacichthys aspro Offers Insights Into Gobioidei Evolution

Molecular Ecology Resources, EarlyView.
ABSTRACT The percomorph fish clade Gobioidei is a suborder that comprises over 2200 species distributed in nearly all aquatic habitats. To understand the genetics underlying their species diversification, we sequenced and annotated the genome of the loach goby, Rhyacichthys aspro, an early‐diverging group, and compared it with nine additional Gobioidei
Tzi‐Yuan Wang, Yu‐Wei Wu, Hao‐Jun Lu, Te‐Yu Liao, Jui‐Hung Tai, Shih‐Pin Huang, Feng‐Yu Wang, Tsung‐Han Yu, Chau‐Ti Ting, Shu‐Miaw Chaw, Hurng‐Yi Wang   +10 more
wiley   +1 more source

Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice

Aging Cell, Volume 24, Issue 5, May 2025.
In aging mice, the submandibular gland, among the three major salivary glands (submandibular, parotid, and sublingual glands), shows a significant increase in senescent cells. This increase disrupts tight junction structures and is closely linked to aging‐related declines in salivary secretion.
Zhuo Chen, Qian‐Ying Mao, Jie‐Yuan Zhang, Yu‐Xiao Wu, Xiao‐Feng Shan, Yan Geng, Jia‐Yi Fan, Zhi‐Gang Cai, Ruo‐Lan Xiang   +8 more
wiley   +1 more source

Targeting CRM1 for Progeria Syndrome Therapy

Aging Cell, Volume 24, Issue 5, May 2025.
Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce, Marlon De Ita, Susana Castro‐Obregón, Diego Cortez, Yosef Landesman, Jonathan J. Magaña, Susana Gonzalo, Tania Zavaleta, Angelica Soberano‐Nieto, Juan Unzueta, Isabel Arrieta‐Cruz, Porfirio Nava, Aurora Candelario‐Martínez, Ian García‐Aguirre, Bulmaro Cisneros   +14 more
wiley   +1 more source

Targeting gene expression to specific cells of kidney tubules in vivo, using adenoviral promoter fragments. [PDF]

PLoS One, 2017
Watanabe S, Ogasawara T, Tamura Y, Saito T, Ikeda T, Suzuki N, Shimosawa T, Shibata S, Chung UI, Nangaku M, Uchida S.   +10 more
europepmc   +1 more source

Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade‐Offs of Drosophila Mothers

Aging Cell, Volume 24, Issue 5, May 2025.
Dietary metal ions significantly influence the lifespan and reproduction of Drosophila females. In this study, we show that not adding any of the metal ions to the diet adversely affects reproduction and lifespan. By contrast, food with no added Zn negatively impacts reproduction but not maternal lifespan, suggesting that female flies stop producing ...
Sweta Sarmah, Hannah Thi‐Hong Hanh Truong, Gawain McColl, Richard Burke, Christen K. Mirth, Matthew D. W. Piper   +5 more
wiley   +1 more source

CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK‐Mediated Autophagy

Aging Cell, Volume 24, Issue 5, May 2025.
This study revealed that the expression of CAV1 is increased in the renal tissues of D‐gal‐induced aging mice and human renal proximal tubular epithelial cells (HK‐2). Using a GST pull‐down assay, it was demonstrated that CAV1 can directly bind to CaMKK2 and inhibit its activity, thereby suppressing the AMPK‐mediated autophagy process and exacerbating ...
Liya Sun, Lujun Xu, Tongyue Duan, Yiyun Xi, Zebin Deng, Shilu Luo, Chongbin Liu, Chen Yang, Huafeng Liu, Lin Sun   +9 more
wiley   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review

Andrology, EarlyView.
Abstract Background Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS‐CoV‐2) infection and Coronavirus Disease 2019 (COVID‐19). Aim To provide an update on the andrological effects of SARS‐CoV‐2 infection and COVID‐19.
Giuseppe Lisco, Anna De Tullio, Maima Matin, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola, Giuseppina Piazzolla, Vincenzo Triggiani   +7 more
wiley   +1 more source