Results 171 to 180 of about 1,118,511 (368)

The Omics‐Driven Machine Learning Path to Cost‐Effective Precision Medicine in Chronic Kidney Disease

PROTEOMICS, EarlyView.
ABSTRACT Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD.
Marta B. Lopes, Roberta Coletti, Flore Duranton, Griet Glorieux, Mayra Alejandra Jaimes Campos, Julie Klein, Matthias Ley, Paul Perco, Alexia Sampri, Aviad Tur‐Sinai   +9 more
wiley   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source

Sex-specific Expression of Estradiol Derivatives, Hydropersulfides and Ether Lipids Regulates Ferroptosis Sensitivity of Kidney Tubules

, 2023
Linkermann A, Belavgeni A, Tonnus W, Maremonti F, Penkov S, Mallais M, Gaillet C, Brucker A, Schilling D, Schlicker L, Himmerkus N, Gavali S, Schlecht M, Flade K, Becker J, Tmava M, Haag A, Hugo C, Schulze A, Plietker B, Becker J, Weinberg J, Lorenz S, Proneth B, Conrad M, Rodriguez R, Bornstein S, Dick T, Pratt D, Fedorova M.   +29 more
europepmc   +1 more source

Automatic detection of calcium phosphate deposit plugs at the terminal ends of kidney tubules. [PDF]

Healthc Technol Lett, 2019
Fernandez K, Korinek M, Camp J, Lieske J, Holmes D.   +4 more
europepmc   +1 more source

Transcellular water flow modulates water channel exocytosis and endocytosis in kidney collecting tubule. [PDF]

, 1991
Michio Kuwahara, Lanbo Shi, Fumiaki Marumo, A.S. Verkman   +3 more
openalex   +1 more source

Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease

PROTEOMICS, EarlyView.
ABSTRACT Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n = 1131) and CKD patients (n = 5585) this aspect was investigated in detail ...
Ioanna K. Mina, Luis F. Iglesias‐Martinez, Matthias Ley, Lucas Fillinger, Paul Perco, Justyna Siwy, Harald Mischak, Vera Jankowski   +7 more
wiley   +1 more source

The Role of Magnesium in Liver Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
Magnesium is a vital mineral involved in over 300 enzymatic reactions, crucial for physiological functions. Its deficiency, common in liver cirrhosis patients, correlates with poor outcomes by affecting inflammation, oxidative stress, fibrosis, and immunity. This review explores magnesium's role in cirrhosis and its interaction with disease mechanisms.
Weiye Zeng, Xudan Wang, He Qi, Hongtao Tang, Xun Qi   +4 more
wiley   +1 more source

RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus. [PDF]

Kidney Int, 2019
Sung CC, Chen L, Limbutara K, Jung HJ, Gilmer GG, Yang CR, Lin SH, Khositseth S, Chou CL, Knepper MA.   +9 more
europepmc   +1 more source

Controlling Drug Release From Supramolecular Polymer Surfaces by a Click‐To‐Release Reaction

Journal of Polymer Science, EarlyView.
We present a strategy combining reactive supramolecular additives with a covalent click‐to‐release reaction for localized drug delivery. A trans‐cyclooctene additive releases a cytotoxic drug upon tetrazine administration. Fluorescent monitoring confirms release, and cytotoxic tests show effective cancer cell death.
Maritza M. Rovers, Joyce E. P. Brouns, Fenna W. B. Craenmehr, Marc Robillard, Joris W. Peeters, Henk M. Janssen, Patricia Y. W. Dankers   +6 more
wiley   +1 more source

Evidence for calcium-dependent control of 1,25-dihydroxyvitamin D3 production by rat kidney proximal tubules.

, 1986
Murray J. Favus, Craig B. Langman
openalex   +1 more source