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Modern biomarkers of acute kidney injury
Фармакоэкономика, 2023 The results of published studies of modern biomarkers used in the diagnosis of acute kidney injury (AKI) were summarized. The search was carried out in the PubMed/MEDLINE, Scopus, eLibrary databases.
D. I. Korabelnikov, M. O. Magomedaliev
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Urinary biomarkers of kidney injury in patients treated with anti-VEGF drugs
Терапевтический архив, 2022 Background. Antiangiogenic drugs are widely used in oncological practice and are aimed at inhibiting angiogenesis. Despite the high antitumor efficacy, their use may be limited by nephrotoxicity, and therefore the search for early biomarkers of kidney ...
Katerina S. Grechukhina +5 more
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Urine NGAL and KIM-1 in children and adolescents with hyperuricemia [PDF]
Pediatric Nephrology, 2013 The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia.The study included 88 children and adolescents (60 males, 28 females) with a median age of 16 (range 11-18.5) years who had been referred to ...
Tomczak, Justyna +2 more
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Elevated Serum KIM-1 in Sepsis Correlates with Kidney Dysfunction and the Severity of Multi-Organ Critical Illness [PDF]
International Journal of Molecular SciencesFrank Tacke +2 more
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Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury
Безопасность и риск фармакотерапии, 2021 Drug-induced kidney injury (DIKI) accounts for 8 to 60% of episodes of acute kidney injury (AKI) among hospital patients. Early DIKI detection and timely adjustment of therapy will help reduce the kidney injury incidence and mortality.
O. V. Muslimova +6 more
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Renal Failure, 2021 Introduction It has been demonstrated that urinary neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin are helpful biomarkers in the differentiation of intrinsic and prerenal acute kidney injury. Objective The present cross-sectional study
Felix S. Seibert +9 more
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Kim-1/Tim-1 and immune cells: shifting sands [PDF]
Kidney International, 2012 Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell
Ichimura, Takaharu +2 more
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Renal Failure, 2020 Background Inhibitors of sodium-glucose co-transporter-2 (SGLT2i) were found to improve renal outcome in diabetic patients in large prospective randomized trials. Yet, SGLT2i may acutely reduce kidney function through volume depletion, altered glomerular
Said Darawshi +7 more
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Исследования и практика в медицине, 2021 Currently, due to the dynamic development of surgical technologies, indications for organ-sparing treatment of kidney cancer are expanding. Acute kidney injury is a serious complication that leads to chronic kidney disease, increased postoperative ...
I. O. Dementev +6 more
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KIM-1–mediated phagocytosis reduces acute injury to the kidney [PDF]
Journal of Clinical Investigation, 2015 Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. Here, we determined that early in the injury process, however, KIM-1 expression is antiinflammatory due to its mediation of phagocytic processes in tubule cells.
Li, Yang +8 more
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