Results 171 to 180 of about 2,580,938 (299)

Activation of the Cdc42p GTPase by cyclin‐dependent protein kinases in budding yeast [PDF]

, 2007
Richelle Sopko, Dongqing Huang, Jeffrey C. Smith, Daniel Figeys, Brenda Andrews   +4 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma [PDF]

, 2010
Alvarez Hector, Elizabeth A. Montgomery, Collins Karikari, Marcia I. Canto, Kerry B. Dunbar, Jean S. Wang, Georg Feldmann, Seung‐Mo Hong, Michael C. Haffner, Alan K. Meeker, Sacha J. Holland, Jiaxin Yu, Thilo J. Heckrodt, Jing Zhang, Pingyu Ding, Dane A. Goff, Rajinder Singh, Juan Carlos Roa, Arivusudar Marimuthu, Gregory J. Riggins, James R. Eshleman, Barry D. Nelkin, Akhilesh Pandey, Anirban Maitra   +23 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Uncovering human kinase substrates in nipah proteome. [PDF]

Front Bioinform
Shaji V, Anil A, Jabbar AA, Mahin A, Rafi A, Revikumar A, Soman S, Prasad G, Pinto SM, Subbannayya Y, Jayanandan A, Raju R.   +11 more
europepmc   +1 more source

Retrospective Analysis of Skin Toxicity in Patients under Anti-EGFR Tyrosine Kinase Inhibitors: Our Experience in Lung Cancer

, 2019
Maria Carmela Annunziata, Maria Ferrillo, Eleonora Cinelli, Luigia Panariello, Danilo Rocco, Gabriella Fabbrocini   +5 more
openalex   +1 more source

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases [PDF]

, 2016
Sharadha Dayalan Naidu, Calum Sutherland, Ying Zhang, Ana Marı́a Risco, Laureano de la Vega, Christopher J. Caunt, C. James Hastie, Douglas J. Lamont, Laura Torrente, Sudhir Chowdhry, Ivor J. Benjamin, Stephen M. Keyse, Ana Cuenda, Albena T. Dinkova‐Kostova   +13 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Association of Venous Thromboembolism Risk with Atopic Dermatitis and Janus Kinase Inhibitors Treatment: A Mendelian Randomization Study. [PDF]

Clin Appl Thromb Hemost
Chen Z, Wang S, Wang Y.
europepmc   +1 more source

Expression of the VRK (vaccinia‐related kinase) gene family of p53 regulators in murine hematopoietic development [PDF]

, 2003
Francisco M. De La Vega, Pilar Gonzalo, Marı́a-Luisa Gaspar, Pedro A. Lazo   +3 more
openalex   +1 more source