Results 11 to 20 of about 3,771,587 (392)

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development

Journal of Experimental & Clinical Cancer Research, 2023
Background Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic process and acts as a “moonlighting” protein to play various functions in diverse cellular processes unrelated to glycolysis.
Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng   +8 more
doaj   +1 more source

Crystal structure of methyl 2-(4-(3-iodopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C15H12IN3O2

Zeitschrift für Kristallographie - New Crystal Structures, 2020
C15H12IN3O2, triclinic, P1̄ (no. 2), a = 4.511(2) Å, b = 11.891(6) Å, c = 14.557(7) Å, α = 109.709(9)°, β = 96.971(9)°, γ = 97.054(9)°, V = 718.4(6) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1052, T = 293(2) K.
Fang Bo, Jiang Fang Fang, Meng Jiang Ping   +2 more
doaj   +1 more source

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

Journal of Biological Chemistry, 1998
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements
M. Favata, K. Horiuchi, E. Manos, A. J. Daulerio, Deborah A. Stradley, W. Feeser, Drew E. Van Dyk, W. Pitts, R. Earl, F. Hobbs, R. Copeland, R. Magolda, P. Scherle, J. Trzăskos   +13 more
semanticscholar   +1 more source

Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction

Beilstein Journal of Organic Chemistry, 2020
A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU.
Yong Li, Zheng Huang, Jia Xu, Yong Ding, Dian-Yong Tang, Jie Lei, Hong-yu Li, Zhong-Zhu Chen, Zhi-Gang Xu   +8 more
doaj   +1 more source

Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]

, 2016
Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T., Callera, Glaucia E., He, Ying, Ryazanov, Alexey G., Ryazanov, Lillia V., Shrier, Alvin, Stewart, Duncan J., Touyz, Rhian, Yogi, Alvaro, Zhai, Alexander   +9 more
core   +1 more source

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome

Biomolecules, 2022
Phosphorylation facilitates the regulation of all fundamental biological processes, which has triggered extensive research of protein kinases and their roles in human health and disease.
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger   +3 more
doaj   +1 more source

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia [PDF]

Journal of Biological Chemistry, 2016
Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance.
Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina, Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K, Bortell, Rita, Alonso, Laura C., Czech, Michael P.   +12 more
openaire   +3 more sources

A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]

, 1988
A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
A.M. Edelman, A.R. Ashton, C. foyer, C. Schindler, C.V.C. Glover, D.J. Arnon, F.A. Ventimiglia, G.E. Lienhard, G.M. Hathaway, G.M. Hathaway, G.M. Hathaway, H. Erdmann, H. Hidaka, J. Joyard, J. Soll, J. Soll, J. Soll, J. Soll, J.F. Allen, J.F. Kuo, J.G. Chafouleas, K. Birkenhead, K. Cline, K. Keegstra, P. Bhalla, R. Ranjeva, R.A. Douce, R.J.H. Budde, S. Gowda, S. Murakami, S.J. Coughlan, T.F.J. Yan, U.K. Laemmli, W.A. Laing, Z.F. Lin   +34 more
core   +1 more source

Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways

Cancer Cell International, 2018
Background Recent studies showed that benzimidazoleisoquinolinone derivatives exhibit anticancer activity against human cancer cell lines. The aim of this study is to evaluate the anti-tumor effects and mechanisms of benzimidazoleisoquinolinones in ...
Ya-Jun Zhang, Zhi-Gang Xu, Shi-Qiang Li, Liu-Jun He, Yan Tang, Zhong-Zhu Chen, Dong-Lin Yang   +6 more
doaj   +1 more source