Results 11 to 20 of about 2,849,925 (342)
Cancer Cell, 2015 In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug
Aroon S. Karra +3 more
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BMJ Open, 2023 Objectives To investigate the underprescription of oral anticoagulation (OAC) in individual atrial fibrillation (AF) patients in primary care.Setting Screening of patient records in 39 participating general practitioners (GPs) across the Netherlands ...
Freek Verheugt +8 more
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Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases [PDF]
Molecular Cell, 2005 Mammalian mitogen-activated protein kinase (MAPK) cascades control various cellular events, ranging from cell growth to apoptosis, in response to external stimuli. A conserved docking site, termed DVD, is found in the mammalian MAP kinase kinases (MAPKKs) belonging to the three major subfamilies, namely MEK1, MKK4/7, and MKK3/6.
Kazuo Tatebayashi +3 more
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Regulation of Cardiac PKA Signaling by cAMP and Oxidants
Antioxidants, 2021 Pathologies, such as cancer, inflammatory and cardiac diseases are commonly associated with long-term increased production and release of reactive oxygen species referred to as oxidative stress.
Friederike Cuello +4 more
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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]
Journal of Biological Chemistry, 2005 The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Anthony R. Means +5 more
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Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study
Molecules, 2021 Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19.
Eleanor L. Atkinson +5 more
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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]
Cell Research, 2010 The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors. However, another important consequence of IKK activation is the regulation of TPL-2, a MEK kinase that is required for activation of ERK-1 ...
Thorsten Gantke +2 more
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Historical data on cardiovascular health in Surinamese men
BMC Research Notes, 2018 Objectives Cardiovascular risk factor burden was recently reported to be high in the Caribbean country Suriname. However, historical data for comparison were lacking.
Lizzy M. Brewster, Jules Brewster
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Crystal structure of methyl 2-(4-(3-iodopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C15H12IN3O2
Zeitschrift für Kristallographie - New Crystal Structures, 2020 C15H12IN3O2, triclinic, P1̄ (no. 2), a = 4.511(2) Å, b = 11.891(6) Å, c = 14.557(7) Å, α = 109.709(9)°, β = 96.971(9)°, γ = 97.054(9)°, V = 718.4(6) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1052, T = 293(2) K.
Fang Bo +2 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic process and acts as a “moonlighting” protein to play various functions in diverse cellular processes unrelated to glycolysis.
Lixia Gao +8 more
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