Results 41 to 50 of about 2,035,205 (298)

Targeting Phosphatases and Kinases: How to Checkmate Cancer

Frontiers in Cell and Developmental Biology, 2021
Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as
Alice Turdo, Caterina D’Accardo, Antonino Glaviano, Gaetana Porcelli, Cristina Colarossi, Lorenzo Colarossi, Marzia Mare, Naida Faldetta, Chiara Modica, Giuseppe Pistone, Maria Rita Bongiorno, Matilde Todaro, Matilde Todaro, Giorgio Stassi   +13 more
doaj   +1 more source

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]

Cell Research, 2010
The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors. However, another important consequence of IKK activation is the regulation of TPL-2, a MEK kinase that is required for activation of ERK-1 ...
Thorsten, Gantke, Srividya, Sriskantharajah, Steven C, Ley   +2 more
openaire   +2 more sources

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
core   +1 more source

A Derivate of Benzimidazole-Isoquinolinone Induces SKP2 Transcriptional Inhibition to Exert Anti-Tumor Activity in Glioblastoma Cells

Molecules, 2019
We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage.
He-ying Chen, Liu-jun He, Shi-qiang Li, Ya-jun Zhang, Jiu-hong Huang, Hong-xia Qin, Juan-li Wang, Qian-yin Li, Dong-lin Yang   +8 more
doaj   +1 more source

Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IKappaB kinase activity and inflammatory responses in endothelial cells [PDF]

, 2011
Background: In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood.
Timo Frömel, Ingrid Fleming, Beß, Elke, Fißlthaler, Beate, Elke Bess, Fleming, Ingrid, Frömel Timo, Bess Elke, Fisslthaler Beate, Beate Fisslthaler, Frömel, Timo, Fleming Ingrid   +11 more
core   +2 more sources

Crystal structure of ethyl (E)-1-(3-ethoxy-3-oxoprop-1-en-1-yl)-2-(4-nitrophenyl)-2,5-dihydro-1H-benzo[b][1,4]diazepine-3-carboxylate, C23H23N3O6

Zeitschrift für Kristallographie - New Crystal Structures, 2019
C23H23N3O6, monoclinic, P21/c (no. 14), a = 11.235(6) Å, b = 11.251(7) Å, c = 17.814(10) Å, β = 98.872(12)°, V = 2225(2) Å3, Z = 4, Rgt(F) = 0.0581, wRref(F2) = 0.1590, T = 296(2) K.
Tan Hong-bo, Hu Chun-sheng
doaj   +1 more source

Large‐scale pathogenicity prediction analysis of cancer‐associated kinase mutations reveals variability in sensitivity and specificity of computational methods

Cancer Medicine, 2023
Background Mutations in kinases are the most frequent genetic alterations in cancer; however, experimental evidence establishing their cancerous nature is available only for a small fraction of these mutants. Aims Predicition analysis of kinome mutations
Sravani Akula, Sai Charitha Mullaguri, Niklas Max Melton, Archana Katta, Venkata Sai Giridhar Reddy Naga, Shyamson Kandula, Raj Kumar Pedada, Janakiraman Subramanian, Rama Krishna Kancha   +8 more
doaj   +1 more source

Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK [PDF]

Journal of Biological Chemistry, 2001
The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway.
I, Gotoh, M, Adachi, E, Nishida
openaire   +2 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Nature Communications
Leucine-rich repeat kinase 2 (LRRK2) is an essential regulator in cellular signaling and a major contributor to Parkinson’s disease (PD) pathogenesis.
Juliana A. Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D. Metcalfe, Mark R. Cookson, Ping Zhang   +6 more
doaj   +1 more source