Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus [PDF]
, 1997 Autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) at threonine-286 produces Ca2+-independent kinase activity and has been proposed to be involved in induction of long-term potentiation by tetanic stimulation in the ...
Harris, Kristen M. +4 more
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Drosophila heat shock response requires the jnk pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif [PDF]
, 2012 Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Garlena, RA, Gonda, RL, Stronach, B
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Zeitschrift für Kristallographie - New Crystal Structures, 2018 C27H22BrClN2O5, triclinic, P1̄, a = 6.8549(4) Å, b = 13.2863(12) Å, c = 14.3690(13) Å, α = 85.944(7)°, β = 84.882(6)°, γ = 89.932(6)°, V = 1300.18(18) Å3, Z = 2, Rgt(F) = 0.0655, wRref(F2) = 0.1841, T = 293(2) K.
Meng Jiang Ping, Lei Jie
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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]
, 2014 BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L +3 more
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Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): The modulatory effect of deep inspiration (DI) on airway constriction is impaired in asthma. However, mechanisms underlying this impairment are not clear.
Saeed Pazhoohan +6 more
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c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
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Loss of the Conserved Alveolate Kinase MAPK2 Decouples
mBio, 2020 Mitogen-activated protein kinases (MAPKs) are a conserved family of protein kinases that regulate signal transduction, proliferation, and development throughout eukaryotes. The apicomplexan parasite Toxoplasma gondii expresses three MAPKs.
Xiaoyu Hu +3 more
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Targeting Phosphatases and Kinases: How to Checkmate Cancer
Frontiers in Cell and Developmental Biology, 2021 Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as
Alice Turdo +13 more
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A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]
, 2012 EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent +12 more
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