Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases [PDF]
Molecular Cell, 2005 Mammalian mitogen-activated protein kinase (MAPK) cascades control various cellular events, ranging from cell growth to apoptosis, in response to external stimuli. A conserved docking site, termed DVD, is found in the mammalian MAP kinase kinases (MAPKKs) belonging to the three major subfamilies, namely MEK1, MKK4/7, and MKK3/6.
Haruo Saito +2 more
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Regulation of MAP kinases by MAP kinase phosphatases
Biochimica Et Biophysica Acta - Molecular Cell Research, 2007 MAP kinase phosphatases (MKPs) catalyze dephosphorylation of activated MAP kinase (MAPK) molecules and deactivate them. Therefore, MKPs play an important role in determining the magnitude and duration of MAPK activities. MKPs constitute a structurally distinct family of dual-specificity phosphatases.
Kunio Kondoh, Eisuke Nishida
exaly +3 more sources
Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. [PDF]
PLoS ONE, 2010 In eukaryotic cell types, virtually all cellular processes are under control of proline-directed kinases and especially MAP kinases. Serine/threonine kinases in general were originally considered as a eukaryote-specific enzyme family.
Malgorzata Miller +12 more
doaj +1 more source
Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites
FEBS Open Bio, 2022 Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways.
Xzaviar K. V. Solone +9 more
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A subcellular map of the human kinome
eLife, 2021 The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates investigation of normal and disease mechanisms.
Haitao Zhang +21 more
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The NDR kinase scaffold HYM1/MO25 is essential for MAK2 map kinase signaling in Neurospora crassa. [PDF]
PLoS Genetics, 2012 Cell communication is essential for eukaryotic development, but our knowledge of molecules and mechanisms required for intercellular communication is fragmentary.
Anne Dettmann +5 more
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Mitogen-activated protein kinases are associated with the regulation of physiological traits and virulence in Fusarium oxysporum f. sp. cubense. [PDF]
PLoS ONE, 2015 Fusarium oxysporum f. sp. cubense (FOC) is an important soil-borne fungal pathogen causing devastating vascular wilt disease of banana plants and has become a great concern threatening banana production worldwide.
Zhaojian Ding +6 more
doaj +1 more source
Activation of p21-activated Kinase 6 by MAP Kinase Kinase 6 and p38 MAP Kinase [PDF]
Journal of Biological Chemistry, 2005 The p21-activated kinases (PAKs) contain an N-terminal Cdc42/Rac interactive binding domain, which in the group 1 PAKs (PAK1, 2, and 3) regulates the activity of an adjacent conserved autoinhibitory domain. In contrast, the group 2 PAKs (PAK4, 5, and 6) lack this autoinhibitory domain and are not activated by Cdc42/Rac binding, and the mechanisms that ...
Ramneet, Kaur +7 more
openaire +2 more sources
Function of MAP kinases in plant signal transduction pathway networks
浙江大学学报. 农业与生命科学版, 2004 Mitogen-activated protein kinase (MAPK) cascade, which consists of three Ser/Thr protein kinases, namely, MAP kinase kinase kinase, MAP kinase kinase and MAP kinase, is a universal module in signal transduction pathways in all eukaryotes.
SONG Dong-hui +2 more
doaj +1 more source