Results 11 to 20 of about 113,529 (264)

Plant Raf-like kinases regulate the mRNA population upstream of ABA-unresponsive SnRK2 kinases under drought stress

Nature Communications, 2020
SnRK2 protein kinases play key roles in signaling during plant responses to abiotic stress. Here Soma et al. report three Arabidopsis Raf-like MAP kinase kinase kinases phosphorylate and activate a subclass of SnRK2s that rapidly respond to osmotic ...
Fumiyuki Soma, Fuminori Takahashi, Takamasa Suzuki, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki   +4 more
doaj   +1 more source

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

Journal of Inflammation, 2006
Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj   +1 more source

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase [PDF]

The EMBO Journal, 1997
The mitogen-activated protein kinase (MAPK) cascade consisting of MAPK and its direct activator, MAPK kinase (MAPKK), is essential for signaling of various extracellular stimuli to the nucleus. Upon stimulation, MAPK is translocated to the nucleus, whereas MAPKK stays in the cytoplasm.
M, Fukuda, Y, Gotoh, E, Nishida
openaire   +2 more sources

MAP Kinase Regulation of the Candida albicans Pheromone Pathway

mSphere, 2019
We investigated the relationships of the Cek1 and Cek2 mitogen-activated protein (MAP) kinases and the putative MAP kinase phosphatase Cpp1 in the mating process of Candida albicans.
Golnaz Rastghalam, Raha Parvizi Omran, Masoumeh Alizadeh, Debrah Fulton, Jaideep Mallick, Malcolm Whiteway   +5 more
doaj   +1 more source

The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. [PDF]

PLoS ONE, 2009
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses.
Katherine R Schouest, Yasuhiro Kurasawa, Tokiko Furuta, Naoki Hisamoto, Kunihiro Matsumoto, Jill M Schumacher   +5 more
doaj   +1 more source

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

Journal of Biological Chemistry, 1993
Xenopus 45-kDa mitogen-activated protein (MAP) kinase kinase (MAPKK) is a serine/threonine/tyrosine kinase, which activates MAP kinase (MAPK) by phosphorylating its threonine and tyrosine residues. MAPKK is active only when its threonine and/or serine residues are phosphorylated.
S, Matsuda, Y, Gotoh, E, Nishida
openaire   +2 more sources

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.

PLoS Computational Biology, 2010
In order to fully understand protein kinase networks, new methods are needed to identify regulators and substrates of kinases, especially for weakly expressed proteins.
Thomas C Whisenant, David T Ho, Ryan W Benz, Jeffrey S Rogers, Robyn M Kaake, Elizabeth A Gordon, Lan Huang, Pierre Baldi, Lee Bardwell   +8 more
doaj   +1 more source

ProKinO: an ontology for integrative analysis of protein kinases in cancer. [PDF]

PLoS ONE, 2011
BACKGROUND: Protein kinases are a large and diverse family of enzymes that are genomically altered in many human cancers. Targeted cancer genome sequencing efforts have unveiled the mutational profiles of protein kinase genes from many different cancer ...
Gurinder Gosal, Krys J Kochut, Natarajan Kannan   +2 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling

Frontiers in Plant Science, 2018
Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or ...
Przemysław Jagodzik, Małgorzata Tajdel-Zielinska, Agata Ciesla, Małgorzata Marczak, Agnieszka Ludwikow   +4 more
doaj   +1 more source

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis

Molecules, 2022
Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but ineffective at killing larval stages of this parasite.
Bernardo Pereira Moreira, Michael H. W. Weber, Simone Haeberlein, Annika S. Mokosch, Bernhard Spengler, Christoph G. Grevelding, Franco H. Falcone   +6 more
doaj   +1 more source