Results 21 to 30 of about 113,529 (264)
Journal of Pharmacological Sciences, 2003 Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
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The role of atypical MAP kinase 4 in the host interaction with Cryptosporidium parvum
Scientific Reports, 2023 Cryptosporidium parvum is an apicomplexan parasite that causes severe zoonotic diarrhea in humans and calves. Since there are no effective treatments or vaccines for infants or immunocompromised patients, it is important to understand the molecular ...
Nina Watanabe +6 more
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Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase [PDF]
Oncogene, 1999 There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well understood.
M W, Kieran +4 more
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BMC Bioinformatics, 2021 Background Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders.
Liang-Chin Huang +7 more
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Allosteric regulation of kinase activity in living cells
eLife, 2023 The dysregulation of protein kinases is associated with multiple diseases due to the kinases' involvement in a variety of cell signaling pathways. Manipulating protein kinase function, by controlling the active site, is a promising therapeutic and ...
Shivani Sujay Godbole +1 more
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MAP3K kinases and kidney injury
Nefrología (English Edition), 2019 Mitogen-activated protein kinases (MAP kinases) are functionally connected kinases that regulate key cellular process involved in kidney disease such as all survival, death, differentiation and proliferation.
Leticia Cuarental +7 more
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Journal of Lipid Research, 2001 This study was conducted on human Jurkat T cell lines to elucidate the role of EPA and DHA, n-3 PUFA, in the modulation of two mitogen-activated protein (MAP) kinases, that is, extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2).
Anne Denys +2 more
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Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK [PDF]
Journal of Biological Chemistry, 2001 The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway.
I, Gotoh, M, Adachi, E, Nishida
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Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells [PDF]
FEBS Letters, 1992 A MAP kinase kinase kinase (MAPKKK) was identified in phaeochromocytoma (PC12) cells which reactivated homogeneous MAP kinase kinase (MAPKK) from rabbit skeletal muscle that had been inactivated by incubation with protein phosphatase 2A. Reactivation was accompanied by stoichiometric phosphorylation of MAPKK on a serine residue(s).
Gomez, Nestor +2 more
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BMC Genomics, 2006 Background As in other eukaryotes, plant mitogen-activated protein kinase (MAPK) cascades are composed of three classes of hierarchically organized protein kinases, namely MAPKKKs, MAPKKs, and MAPKs.
Ellis Brian E +5 more
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