Results 41 to 50 of about 117,345 (315)

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Remenyi, A, Attila Reményi, Glatz, G, Alexa, A, Glatz, Gábor, Gábor Glatz, Gogl, G, Alexa, Anita, Gógl, Gergő, Anita Alexa, Reményi, Attila, Gergő Gógl   +11 more
core   +1 more source

Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells

Journal of Lipid Research, 2001
This study was conducted on human Jurkat T cell lines to elucidate the role of EPA and DHA, n-3 PUFA, in the modulation of two mitogen-activated protein (MAP) kinases, that is, extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2).
Anne Denys, Aziz Hichami, Naim Akhtar Khan   +2 more
doaj   +1 more source

Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]

, 2002
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner, Erich A. Nigg, Oliver J. Gruss, Silljé, Herman H. W., Gruss, O. J., Kufer, T. A., Körner, R., Nigg, E. A., Meraldi, P., Sillje, H. H. W., Thomas A. Kufer, Kufer, Thomas A., Gruss, Oliver J., Nigg, Erich A., Koerner, R., Patrick Meraldi, Körner, Roman, Meraldi, Patrick, Herman H.W. Silljé   +18 more
core   +1 more source

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations

Frontiers in Bioscience-Landmark, 2022
Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have ...
Khoa Nguyen, Hassan Yousefi, Thomas Cheng, Justin Magrath, Alifiani B. Hartono, Madlin Alzoubi, Katherine Hebert, Courtney K. Brock, Maryl K. Wright, Charles Ethan Byrne, Andrew Rivera, Sam C. Okpechi, Margarite Delores Matossian, Henri Wathieu, Steven Elliott, Mark J. Mondrinos, Sean B. Lee, Bridgette M. Collins-Burow, Suresh K. Alahari, David H. Drewry, Matthew E. Burow   +20 more
doaj   +1 more source

MAP-ping genomic organization and organ-specific expression profiles of poplar MAP kinases and MAP kinase kinases

BMC Genomics, 2006
Background As in other eukaryotes, plant mitogen-activated protein kinase (MAPK) cascades are composed of three classes of hierarchically organized protein kinases, namely MAPKKKs, MAPKKs, and MAPKs.
Ellis Brian E, Beaudoin Nathalie, Morency Marie-Josée, Hamel Louis-Philippe, Nicole Marie-Claude, Séguin Armand   +5 more
doaj   +1 more source

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

Molecules, 2021
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate soluble ...
Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach   +16 more
doaj   +1 more source

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

BWMK1, a Novel MAP Kinase Induced by Fungal Infection and Mechanical Wounding in Rice

Molecular Plant-Microbe Interactions, 1999
The activation of the mitogen-activated protein (MAP) kinases by different environmental stresses has been previously observed in several dicot plant species. Here, we report the isolation of a novel MAP kinase in rice that is induced during infection by
Chaozu He, Steven Haw Tien Fong, Daichang Yang, Guo-Liang Wang   +3 more
doaj   +1 more source

Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage

Cell Reports, 2013
DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors (TFs) are not well ...
Eric J. Jaehnig, Dwight Kuo, Hans Hombauer, Trey G. Ideker, Richard D. Kolodner   +4 more
doaj   +1 more source

MAP kinase and pain [PDF]

Brain Research Reviews, 2009
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK family consists of three major members: extracellular signal-regulated kinases (ERK), p38, and c-Jun N-terminal kinase (JNK), which represent three separate signaling ...
Ji, Ru-Rong, Gereau, Robert W., Malcangio, Marzia, Strichartz, Gary R.   +3 more
openaire   +3 more sources