Results 61 to 70 of about 113,529 (264)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

Journal of Pharmacological Sciences, 2003
Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi, Jun-ichi Abe, Koichiro Tsuchiya, Bradford C. Berk, Toshiaki Tamaki   +4 more
doaj   +1 more source

Bayesian analysis of dynamic phosphoproteomic data identifies protein kinases mediating GPCR responses

Cell Communication and Signaling, 2022
Background A major goal in the discovery of cellular signaling networks is to identify regulated phosphorylation sites (“phosphosites”) and map them to the responsible protein kinases.
Kirby T. Leo, Chung-Lin Chou, Chin-Rang Yang, Euijung Park, Viswanathan Raghuram, Mark A. Knepper   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Protein kinases as potential anticandidal drug targets

Frontiers in Bioscience-Landmark, 2020
Candidal infections are increasing at an alarming rate due to hospital acquired infections causing high mortality rates worldwide. Moreover, the emergence of drug resistant Candida strains is the major impediment against effective therapeutics.
Shweta Singh, Suriya Rehman, Zeeshan Fatima, Saif Hameed   +3 more
doaj   +1 more source

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase [PDF]

Journal of Biological Chemistry, 1999
Internalization of activated receptors from the plasma membrane has been implicated in the activation of mitogen-activated protein (MAP) kinase. However, the mechanism whereby membrane trafficking may regulate mitogenic signaling remains unclear.
O, Kranenburg, I, Verlaan, W H, Moolenaar   +2 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Construction of human activity‐based phosphorylation networks

Molecular Systems Biology, 2013
The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks.
Robert H Newman, Jianfei Hu, Hee‐Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne‐Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu, Jiang Qian   +33 more
doaj   +1 more source

The Cryptosporidium parvum Kinome

BMC Genomics, 2011
Background Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections.
Artz Jennifer D, Wernimont Amy K, Allali-Hassani Abdellah, Zhao Yong, Amani Mehrnaz, Lin Yu-Hui, Senisterra Guillermo, Wasney Gregory A, Fedorov Oleg, King Oliver, Roos Annette, Lunin Vlad V, Qiu Wei, Finerty Patrick, Hutchinson Ashley, Chau Irene, von Delft Frank, MacKenzie Farrell, Lew Jocelyne, Kozieradzki Ivona, Vedadi Masoud, Schapira Matthieu, Zhang Chao, Shokat Kevan, Heightman Tom, Hui Raymond   +25 more
doaj   +1 more source