Results 51 to 60 of about 117,345 (315)

Trypanosoma brucei Lipophosphoglycan Activates Host Immune Responses via the TLR-mediated p38 MAP Kinase and NF-κB Pathways

Zoonoses, 2023
This study was aimed at investigating the immunoregulatory effects of trypanosomal lipophosphoglycan (LPG) anchored to trypanosome membranes, including the formation of neutrophil extracellular traps (NETs) and neutrophil cytokine release after parasite ...
Kai Zhang, Ning Jiang, Naiwen Zhang, Liying Yu, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +7 more
doaj   +1 more source

Interacting protein kinases involved in the regulation of flagellar length

, 2006
A striking difference of the life stages of the protozoan parasite Leishmania is a long flagellum in the insect stage promastigotes and a rudimentary organelle in the mammalian amastigotes.
Scholz, M., Melzer, I.M., Erdmann, M., Schmetz, C., Wiese, M.   +4 more
core   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars, A Funding, JS Arthur, Johansen, Claus, Kragballe, Knud, BM Bibby, Lilleholt, Louise Langer, Funding, Anne, L Iversen, Bibby, Bo Martin, K Kragballe, C Johansen, Arthur, J. Simon C.; id_orcid, LL Lilleholt   +13 more
core   +1 more source

Identifying the role of Mer receptor tyrosine kinase in glioblastoma multiforme [PDF]

, 2012
GBM is one of the most aggressive human cancers. Primary GBM, which comprises more than 90% of biopsied or resected brain tumors, arises de novo without an antecedent history of low-grade disease.
Yuhua, Wang
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells

, 2010
In this study we used adenovirus infection to overexpress the dual specific phosphatase, MAP kinase phosphatase-2 (MKP-2), in human umbilical vein endothelial cells and examined inflammatory protein expression and apoptosis, two key features of ...
Mashael Al-Mutairi, Cadalbert, Laurence, Plevin, Robin, Robin Plevin, Laurence Cadalbert, Sameer Al-Harthi, Al-Harthi, Sameer, Al-Mutairi, Mashael, Plevin, R.J.   +8 more
core   +1 more source

Casein kinase 2 controls synapse organization and stability [PDF]

, 2013
Synapse remodeling is a local and dynamic process, requiring constant modifications of the neuronal network. Post-translational modifications, such as reversible phosphorylation by kinases and phosphatases, play a crucial role in synapse development and ...
Bulat, Victoria
core   +1 more source

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source

Importance of MAP kinases during protoperithecial morphogenesis in Neurospora crassa. [PDF]

PLoS ONE, 2012
In order to produce multicellular structures filamentous fungi combine various morphogenetic programs that are fundamentally different from those used by plants and animals.
Alexander Lichius, Kathryn M Lord, Chris E Jeffree, Radek Oborny, Patid Boonyarungsrit, Nick D Read   +5 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source