Results 61 to 70 of about 2,607,457 (313)

The secret life of kinases: functions beyond catalysis

Cell Communication and Signaling, 2011
Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic ...
Romano David, Volinsky Natalia, Rauch Jens, Kolch Walter   +3 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Analysis of some flavonoids for inhibitory mechanism against cancer target phosphatidylinositol 3-kinase (PI3K) using computational tool

Frontiers in Pharmacology, 2023
Cancer has been one of the leading causes of mortality worldwide over the past few years. Some progress has been made in the development of more effective cancer therapeutics, resulting in improved survival rates. However, the desired outcome in the form
Mohd Suhail, Mohd Suhail, Wejdan M. AlZahrani, Shazi Shakil, Shazi Shakil, Shazi Shakil, Mohammad Tarique, Shams Tabrez, Shams Tabrez, Torki A. Zughaibi, Torki A. Zughaibi, Mohd Rehan, Mohd Rehan   +12 more
doaj   +1 more source

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source

In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors

Biology, 2014
Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls
Thi-My-Nhung Hoang, Hong-Lien Vu, Ly-Thuy-Tram Le, Chi-Hung Nguyen, Annie Molla   +4 more
doaj   +1 more source

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila

mBio, 2023
Toxin-antitoxin (TA) systems are abundant genetic modules in bacterial chromosomes and on mobile elements. They are often patchily distributed, as a consequence of horizontal exchange, and the breadth of their functionality in bacterial physiology ...
Jordan D. Lin, Peter J. Stogios, Kento T. Abe, Avril Wang, John MacPherson, Tatiana Skarina, Anne-Claude Gingras, Alexei Savchenko, Alexander W. Ensminger   +8 more
doaj   +1 more source

Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria [PDF]

, 1985
A series of plasmids containing different segments of the v-abl oncogene have been constructed to express different portions of the v- abl protein in bacteria.
Baltimore, David, Wang, Jean Y. J.
core  

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Compound 7 h exerts its anti-oncogenic effects on colorectal cancer cells by inducing death-receptor-mediated apoptosis, promoting DNA damage, and obstructing autophagic flux

BMC Pharmacology and Toxicology
Background and aim Previous research described a catalyst-free, post-Ugi synthesis of two distinct series of highly substituted fused pyrazolo-pyrazines. One of these series demonstrated antitumor activity against colorectal cancer (CRC) cells.
Donglin Yang, Yanlai Fu, Jiuhong Huang, Tianzhi Zhang, Hongyi Nie, Yajun Zhang   +5 more
doaj   +1 more source