Results 51 to 60 of about 2,607,457 (313)
Molecules, 2019 We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage.
He-ying Chen +8 more
doaj +1 more source
Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]
, 2011 Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Berberich, Nina +11 more
core +1 more source
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C23H23N3O6, monoclinic, P21/c (no. 14), a = 11.235(6) Å, b = 11.251(7) Å, c = 17.814(10) Å, β = 98.872(12)°, V = 2225(2) Å3, Z = 4, Rgt(F) = 0.0581, wRref(F2) = 0.1590, T = 296(2) K.
Tan Hong-bo, Hu Chun-sheng
doaj +1 more source
Cancer Medicine, 2023 Background Mutations in kinases are the most frequent genetic alterations in cancer; however, experimental evidence establishing their cancerous nature is available only for a small fraction of these mutants. Aims Predicition analysis of kinome mutations
Sravani Akula +8 more
doaj +1 more source
TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]
, 2014 In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core +2 more sources
14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state
Nature CommunicationsLeucine-rich repeat kinase 2 (LRRK2) is an essential regulator in cellular signaling and a major contributor to Parkinson’s disease (PD) pathogenesis.
Juliana A. Martinez Fiesco +6 more
doaj +1 more source
Crystal structure 1-cinnamyl-2-((Z)-styryl)-1H-benzo[d]imidazole — methanol (1/1), C24H20N2 ⋅ CH4O
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C24H20N2 ⋅ CH4O, monoclinic, P21/n (no. 14), a = 12.764(3) Å, b = 8.744(2) Å, c = 18.733(5) Å, β = 93.944(5)°, V = 2085.8(9) Å3, Z = 4, Rgt(F) = 0.0501, wRref(F2) = 0.1447, T = 296(2) K.
Tan Hong-Bo, Huang Zheng
doaj +1 more source
The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes [PDF]
, 1991 We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes.
Drenkhan, M. +4 more
core
Nonspecific, Reversible Inhibition of Voltage-Gated Calcium Channels by CaMKII Inhibitor CK59 [PDF]
, 2013 Investigation of kinase-related processes often uses pharmacological inhibition to reveal pathways in which kinases are involved. However, one concern about using such kinase inhibitors is their potential lack of specificity.
Kahrls, Andrew S., Mynlieff, Michelle
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source