Results 21 to 30 of about 3,594,281 (409)

Integrin Adhesion: When Is a Kinase a Kinase? [PDF]

Current Biology, 2002
Recent genetic studies in the worm Caenorhabditis elegans and fruitfly Drosophila have revealed the essential role integrin-linked kinase plays in integrin adhesion - but it apparently acts in this role as an adaptor rather than a kinase.
Christos G. Zervas, Nicholas H. Brown
openaire   +3 more sources

A Kinase Divided [PDF]

Cancer Cell, 2015
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug
Aroon S. Karra, Clinton A. Taylor, Curtis A. Thorne, Melanie H. Cobb   +3 more
openaire   +3 more sources

Screening over 100 000 patients in 39 general practices in the Netherlands for anticoagulation underprescription in atrial fibrillation: a descriptive, cross-sectional study

BMJ Open, 2023
Objectives To investigate the underprescription of oral anticoagulation (OAC) in individual atrial fibrillation (AF) patients in primary care.Setting Screening of patient records in 39 participating general practitioners (GPs) across the Netherlands ...
Freek Verheugt, Sander van Doorn, Martin E W Hemels, Ron Pisters, Leonard Voorhout, Constants H P H Geurts, Andrew Oostindjer, Harrie Rila, Wessel W Fuijkschot   +8 more
doaj   +1 more source

Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases [PDF]

Molecular Cell, 2005
Mammalian mitogen-activated protein kinase (MAPK) cascades control various cellular events, ranging from cell growth to apoptosis, in response to external stimuli. A conserved docking site, termed DVD, is found in the mammalian MAP kinase kinases (MAPKKs) belonging to the three major subfamilies, namely MEK1, MKK4/7, and MKK3/6.
Kazuo Tatebayashi, Mutsuhiro Takekawa, Mutsuhiro Takekawa, Haruo Saito   +3 more
openaire   +3 more sources

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]

Cell Research, 2010
The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors. However, another important consequence of IKK activation is the regulation of TPL-2, a MEK kinase that is required for activation of ERK-1 ...
Thorsten Gantke, Srividya Sriskantharajah, Steven C. Ley   +2 more
openaire   +3 more sources

Historical data on cardiovascular health in Surinamese men

BMC Research Notes, 2018
Objectives Cardiovascular risk factor burden was recently reported to be high in the Caribbean country Suriname. However, historical data for comparison were lacking.
Lizzy M. Brewster, Jules Brewster
doaj   +1 more source

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development

Journal of Experimental & Clinical Cancer Research, 2023
Background Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic process and acts as a “moonlighting” protein to play various functions in diverse cellular processes unrelated to glycolysis.
Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng   +8 more
doaj   +1 more source

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]

Journal of Biological Chemistry, 2005
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Anthony R. Means, Jeanne M. Franzone, Rebecca L. Hurley, Bruce E. Kemp, Lee A. Witters, Kristin A. Anderson   +5 more
openaire   +3 more sources

Role of AMP-activated protein kinase in mechanism of metformin action.

Journal of Clinical Investigation, 2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects
Gaochao Zhou, R. W. Myers, Ying Li, Yuli Chen, Xiaolan Shen, J. Fenyk-Melody, Margaret S. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M. Hirshman, L. Goodyear, D. Moller   +13 more
semanticscholar   +1 more source

Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells [PDF]

FEBS Letters, 1992
A MAP kinase kinase kinase (MAPKKK) was identified in phaeochromocytoma (PC12) cells which reactivated homogeneous MAP kinase kinase (MAPKK) from rabbit skeletal muscle that had been inactivated by incubation with protein phosphatase 2A. Reactivation was accompanied by stoichiometric phosphorylation of MAPKK on a serine residue(s).
Gomez, Nestor, Traverse, Sarah, Cohen, Philip   +2 more
openaire   +4 more sources