Results 21 to 30 of about 2,587,181 (193)

Design, Synthesis, and Biochemical Evaluation of New Triazole Derivatives as Aurora-A Kinase Inhibitors

Molecules, 2021
Aurora-A kinase, a key mitosis regulator, is expressed in a cell cycle-dependent manner and has an essential role in maintaining chromosomal stability and the normal progression of the cell through mitosis.
Omeima Abdullah
doaj   +1 more source

Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]

, 2016
Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T., Callera, Glaucia E., He, Ying, Ryazanov, Alexey G., Ryazanov, Lillia V., Shrier, Alvin, Stewart, Duncan J., Touyz, Rhian, Yogi, Alvaro, Zhai, Alexander   +9 more
core   +1 more source

Regulation of Cardiac PKA Signaling by cAMP and Oxidants

Antioxidants, 2021
Pathologies, such as cancer, inflammatory and cardiac diseases are commonly associated with long-term increased production and release of reactive oxygen species referred to as oxidative stress.
Friederike Cuello, Friedrich W. Herberg, Konstantina Stathopoulou, Philipp Henning, Simon Diering   +4 more
doaj   +1 more source

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

Molecules, 2021
Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19.
Eleanor L. Atkinson, Jessica Iegre, Paul D. Brear, Elizabeth A. Zhabina, Marko Hyvönen, David R. Spring   +5 more
doaj   +1 more source

A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]

, 1988
A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
A.M. Edelman, A.R. Ashton, C. foyer, C. Schindler, C.V.C. Glover, D.J. Arnon, F.A. Ventimiglia, G.E. Lienhard, G.M. Hathaway, G.M. Hathaway, G.M. Hathaway, H. Erdmann, H. Hidaka, J. Joyard, J. Soll, J. Soll, J. Soll, J. Soll, J.F. Allen, J.F. Kuo, J.G. Chafouleas, K. Birkenhead, K. Cline, K. Keegstra, P. Bhalla, R. Ranjeva, R.A. Douce, R.J.H. Budde, S. Gowda, S. Murakami, S.J. Coughlan, T.F.J. Yan, U.K. Laemmli, W.A. Laing, Z.F. Lin   +34 more
core   +1 more source

Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

Pharmaceuticals, 2022
The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications.
Saiful Islam, Theodosia Teo, Malika Kumarasiri, Martin Slater, Jennifer H. Martin, Shudong Wang, Richard Head   +6 more
doaj   +1 more source

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. [PDF]

, 2015
PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Akers, Amy L, Austin, Cecilia, Awad, Issam A, De Souza, Jorge Marcondes, Gallione, Carol J, Gunel, Murat, Lee, Connie, Marchuk, Douglas A, McDonald, David A, Mikati, Abdul Ghani, Min, Wang, Rebeiz, Tania, Rorrer, Autumn, Shenkar, Robert, Shi, Changbin, Stockton, Rebecca A, Zhang, Lingjiao   +16 more
core   +2 more sources

Crystal structure of diethyl 2-(4-methoxyphenyl)-1-phenyl-1,2-dihydropyridine-3,5-dicarboxylate, C24H25NO5

Zeitschrift für Kristallographie - New Crystal Structures, 2019
C24H25NO5, triclinic, P1̄, a = 9.2625(8) Å, b = 10.5974(10) Å, c = 11.7431(11) Å, α = 77.836(8)°, β = 87.564(8)°, γ = 66.951(9)°, V = 1035.83(17) Å3, Z = 2, Rgt(F) = 0.0404, wRref(F2) = 0.0985, T = 107.5 K.
Tan Hong-Bo, Meng Jiang-Ping
doaj   +1 more source

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source