Results 21 to 30 of about 3,631,373 (391)

Multifunctional Novel Nanoplatform for Effective Synergistic Chemo-Photodynamic Therapy of Breast Cancer by Enhancing DNA Damage and Disruptions of Its Reparation

Molecules, 2023
Photodynamic therapy (PDT) is an effective noninvasive therapeutic strategy that has been widely used for anti-tumor therapy by the generation of excessive highly cytotoxic ROS.
Zheng Huang, Tong Xian, Xiangyi Meng, Huaisong Hu, Lixia Gao, Jiuhong Huang, Donglin Yang, Kepeng Ou, Bochu Wang, Yimei Zhang   +9 more
doaj   +1 more source

A Kinase Divided [PDF]

Cancer Cell, 2015
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug
Aroon S. Karra, Clinton A. Taylor, Curtis A. Thorne, Melanie H. Cobb   +3 more
openaire   +3 more sources

Screening over 100 000 patients in 39 general practices in the Netherlands for anticoagulation underprescription in atrial fibrillation: a descriptive, cross-sectional study

BMJ Open, 2023
Objectives To investigate the underprescription of oral anticoagulation (OAC) in individual atrial fibrillation (AF) patients in primary care.Setting Screening of patient records in 39 participating general practitioners (GPs) across the Netherlands ...
Freek Verheugt, Sander van Doorn, Martin E W Hemels, Ron Pisters, Leonard Voorhout, Constants H P H Geurts, Andrew Oostindjer, Harrie Rila, Wessel W Fuijkschot   +8 more
doaj   +1 more source

Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases [PDF]

Molecular Cell, 2005
Mammalian mitogen-activated protein kinase (MAPK) cascades control various cellular events, ranging from cell growth to apoptosis, in response to external stimuli. A conserved docking site, termed DVD, is found in the mammalian MAP kinase kinases (MAPKKs) belonging to the three major subfamilies, namely MEK1, MKK4/7, and MKK3/6.
Kazuo Tatebayashi, Mutsuhiro Takekawa, Mutsuhiro Takekawa, Haruo Saito   +3 more
openaire   +3 more sources

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]

Journal of Biological Chemistry, 2005
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Anthony R. Means, Jeanne M. Franzone, Rebecca L. Hurley, Bruce E. Kemp, Lee A. Witters, Kristin A. Anderson   +5 more
openaire   +3 more sources

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase [PDF]

Cell Research, 2010
The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors. However, another important consequence of IKK activation is the regulation of TPL-2, a MEK kinase that is required for activation of ERK-1 ...
Thorsten Gantke, Srividya Sriskantharajah, Steven C. Ley   +2 more
openaire   +3 more sources

Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells [PDF]

FEBS Letters, 1992
A MAP kinase kinase kinase (MAPKKK) was identified in phaeochromocytoma (PC12) cells which reactivated homogeneous MAP kinase kinase (MAPKK) from rabbit skeletal muscle that had been inactivated by incubation with protein phosphatase 2A. Reactivation was accompanied by stoichiometric phosphorylation of MAPKK on a serine residue(s).
Gomez, Nestor, Traverse, Sarah, Cohen, Philip   +2 more
openaire   +4 more sources

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

Journal of Biological Chemistry, 1993
Xenopus 45-kDa mitogen-activated protein (MAP) kinase kinase (MAPKK) is a serine/threonine/tyrosine kinase, which activates MAP kinase (MAPK) by phosphorylating its threonine and tyrosine residues. MAPKK is active only when its threonine and/or serine residues are phosphorylated.
Satoshi Matsuda, Yukiko Gotoh, Eisuke Nishida   +2 more
openaire   +3 more sources

Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK [PDF]

Journal of Biological Chemistry, 2001
The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway.
Makoto Adachi, Isamu Gotoh, Eisuke Nishida   +2 more
openaire   +3 more sources

Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase [PDF]

Molecular and Cellular Biology, 1998
IkappaB kinases (IKKalpha and IKKbeta) are key components of the IKK complex that mediates activation of the transcription factor NF-kappaB in response to extracellular stimuli such as inflammatory cytokines, viral and bacterial infection, and UV irradiation.
Anning Lin, Joseph A. DiDonato, Shino Nemoto   +2 more
openaire   +3 more sources