Results 51 to 60 of about 3,631,373 (391)
Molecules, 2019 We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage.
He-ying Chen +8 more
doaj +1 more source
TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]
, 2014 In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
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Zeitschrift für Kristallographie - New Crystal Structures, 2019 C23H23N3O6, monoclinic, P21/c (no. 14), a = 11.235(6) Å, b = 11.251(7) Å, c = 17.814(10) Å, β = 98.872(12)°, V = 2225(2) Å3, Z = 4, Rgt(F) = 0.0581, wRref(F2) = 0.1590, T = 296(2) K.
Tan Hong-bo, Hu Chun-sheng
doaj +1 more source
c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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Crystal structure 1-cinnamyl-2-((Z)-styryl)-1H-benzo[d]imidazole — methanol (1/1), C24H20N2 ⋅ CH4O
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C24H20N2 ⋅ CH4O, monoclinic, P21/n (no. 14), a = 12.764(3) Å, b = 8.744(2) Å, c = 18.733(5) Å, β = 93.944(5)°, V = 2085.8(9) Å3, Z = 4, Rgt(F) = 0.0501, wRref(F2) = 0.1447, T = 296(2) K.
Tan Hong-Bo, Huang Zheng
doaj +1 more source
Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
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IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
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Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]
Journal of Biological Chemistry, 2005 (R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S. +21 more
openaire +6 more sources
The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes [PDF]
, 1991 We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes.
Drenkhan, M. +4 more
core
Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. [PDF]
, 2015 PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Akers, Amy L +16 more
core +2 more sources