Results 51 to 60 of about 3,327,333 (431)
Using the structural kinome to systematize kinase drug discovery [PDF]
arXiv, 2021 Kinase-targeted drug design is challenging. It requires designing inhibitors that can bind to specific kinases when all kinase catalytic domains share a common folding scaffold that binds ATP. Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
arxiv
Metabolic Kinases Moonlighting as Protein Kinases [PDF]
Trends in Biochemical Sciences, 2018 Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin Lu, Zhimin Lu, Tony Hunter
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The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src [PDF]
, 2007 The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
A Schambony +32 more
core +10 more sources
Molecules, 2019 We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage.
He-ying Chen +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
doaj +1 more source
Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport
Frontiers in Cell and Developmental Biology, 2022 Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions determine the direction, timing and flux of various intracellular transports.
Diksha Kumari, Krishanu Ray
doaj +1 more source
Advance in Reversible Covalent Kinase Inhibitors [PDF]
arXiv, 2021 Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv
Crystal structure 1-cinnamyl-2-((Z)-styryl)-1H-benzo[d]imidazole — methanol (1/1), C24H20N2 ⋅ CH4O
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C24H20N2 ⋅ CH4O, monoclinic, P21/n (no. 14), a = 12.764(3) Å, b = 8.744(2) Å, c = 18.733(5) Å, β = 93.944(5)°, V = 2085.8(9) Å3, Z = 4, Rgt(F) = 0.0501, wRref(F2) = 0.1447, T = 296(2) K.
Tan Hong-Bo, Huang Zheng
doaj +1 more source
A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]
arXiv, 2022 The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]
, 2008 We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel +81 more
core +1 more source